TriGalNAc CBz
Based on 1 Customer Validation
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.73%
- CAS. Nr.: 186613-57-0
- Formel: C34H35NO11
- Molecular Weight:633.64
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
TriGalNAc CBz acts as the linker and can be used for synthesis of GalNAc-LYTACs. TriGalNAc CBz binds to the ASGPR receptor specifically expressed in hepatocytes, transports the target protein and the receptor complex to the endosome. Tri-GalNAc would be released in the acidic environment of the endosome, and the target protein is transported to the lysosome, where it is degraded[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 186613-57-0
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Appearance Solid
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Molecular Weight 633.64
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Formel C34H35NO11
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C1)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)OCCCCC(O)=O)COC(C3=CC=CC=C3)=O)OC(C4=CC=CC=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (157.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kallanthottathil G. Rajeev, et al. Compositions and methods for targeted rna delivery. WO2021178725.
[2]. Biessen EA, Sliedregt-Bol K, 'T Hoen PA, et al. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug Chem. 2002;13(2):295-302. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5782 mL | 7.8909 mL | 15.7818 mL | 39.4546 mL |
| 5 mM | 0.3156 mL | 1.5782 mL | 3.1564 mL | 7.8909 mL | |
| 10 mM | 0.1578 mL | 0.7891 mL | 1.5782 mL | 3.9455 mL | |
| 15 mM | 0.1052 mL | 0.5261 mL | 1.0521 mL | 2.6303 mL | |
| 20 mM | 0.0789 mL | 0.3945 mL | 0.7891 mL | 1.9727 mL | |
| 25 mM | 0.0631 mL | 0.3156 mL | 0.6313 mL | 1.5782 mL | |
| 30 mM | 0.0526 mL | 0.2630 mL | 0.5261 mL | 1.3152 mL | |
| 40 mM | 0.0395 mL | 0.1973 mL | 0.3945 mL | 0.9864 mL | |
| 50 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7891 mL | |
| 60 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6576 mL | |
| 80 mM | 0.0197 mL | 0.0986 mL | 0.1973 mL | 0.4932 mL | |
| 100 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3945 mL |
TriGalNAc CBz Related Classifications
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