Tri-GalNAc(OAc)3-Perfluorophenyl

Cat. No.: HY-145368B Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation. tri-GalNAc: triantenerrary N-acetylgalactosamine; LYTAC: lysosome-targeting chimera.

For research use only. We do not sell to patients.

Tri-GalNAc(OAc)3-Perfluorophenyl Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1840	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2950	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tri-GalNAc(OAc)3-Perfluorophenyl:

Tri-GalNAc-NHS ester Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

2280.29

Formula

C₉₉H₁₅₁F₅N₁₀O₄₄

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(CCOCCOCCOCCOCCOCCC(OC1=C(F)C(F)=C(F)C(F)=C1F)=O)NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2COC(C)=O)[C@@H]([C@H]([C@H]2OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]3COC(C)=O)[C@@H]([C@H]([C@H]3OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]4COC(C)=O)[C@@H]([C@H]([C@H]4OC(C)=O)OC(C)=O)NC(C)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (21.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4385 mL	2.1927 mL	4.3854 mL
5 mM	0.0877 mL	0.4385 mL	0.8771 mL
10 mM	0.0439 mL	0.2193 mL	0.4385 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (252 KB) HNMR (468 KB) CNMR (462 KB) MS (77 KB)

Handling Instructions (2659 KB)

References

[1]. Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7(3):499-506. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.4385 mL	2.1927 mL	4.3854 mL	10.9635 mL
	5 mM	0.0877 mL	0.4385 mL	0.8771 mL	2.1927 mL
	10 mM	0.0439 mL	0.2193 mL	0.4385 mL	1.0964 mL
	15 mM	0.0292 mL	0.1462 mL	0.2924 mL	0.7309 mL
	20 mM	0.0219 mL	0.1096 mL	0.2193 mL	0.5482 mL