Mal-C2-amide-C10-tri-GalNAc

Cat. No.: HY-171342: Data Sheet Handling Instructions
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Mal-C2-amide-C10-tri-GalNAc (Compound 1226) is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeted bifunctional molecules. Mal-C2-amide-C10-tri-GalNAc promotes the sequestration and degradation of extracellular target molecules in lysosomes. Mal-C2-amide-C10-tri-GalNAc is used in the research of autoimmune diseases.

For research use only. We do not sell to patients.

Mal-C2-amide-C10-tri-GalNAc Chemical Structure

CAS No. : 2893765-20-1

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Description

Molecular Weight

1749.99

Formula

C₇₉H₁₃₆N₁₂O₃₁

CAS No.

2893765-20-1

SMILES

CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(C)=O)=O)=O)(NC(CCCCCCCCCCC(NCCN3C(C=CC3=O)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O)=O)=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (57.14 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5714 mL	2.8572 mL	5.7143 mL
5 mM	0.1143 mL	0.5714 mL	1.1429 mL
10 mM	0.0571 mL	0.2857 mL	0.5714 mL

View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Darrin Anthony Lindhout, et al. Lysosomal targeting bifunctional molecules for degradation of autoantibodies. WO2024155750A1. 2025-07-18.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.5714 mL	2.8572 mL	5.7143 mL	14.2858 mL
	5 mM	0.1143 mL	0.5714 mL	1.1429 mL	2.8572 mL
	10 mM	0.0571 mL	0.2857 mL	0.5714 mL	1.4286 mL
	15 mM	0.0381 mL	0.1905 mL	0.3810 mL	0.9524 mL
	20 mM	0.0286 mL	0.1429 mL	0.2857 mL	0.7143 mL
	25 mM	0.0229 mL	0.1143 mL	0.2286 mL	0.5714 mL
	30 mM	0.0190 mL	0.0952 mL	0.1905 mL	0.4762 mL
	40 mM	0.0143 mL	0.0714 mL	0.1429 mL	0.3571 mL
	50 mM	0.0114 mL	0.0571 mL	0.1143 mL	0.2857 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.