2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Olezarsen sodium

Olezarsen sodium  (Synonyms: ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium)

Cat. No.: HY-153491A Purity: 96.53%
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Handling Instructions Technical Support

Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease.

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20)

Olezarsen sodium Chemical Structure

CAS No. : 2298451-31-5

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Based on 1 publication(s) in Google Scholar

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Olezarsen sodium Related Antibodies

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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Description

Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease[1][2][3].

IC50 & Target

apoC3

 

In Vitro

Olezarsen not only reduces triglycerides and APOC3, but also decreases ApoB and non-HDL-C. Moreover, it improves dyslipidemia risk through multiple mechanisms, including reducing triglyceride-rich lipoprotein (TRL) remnants, remodeling low-density lipoprotein (LDL) particles, and increasing specific high-density lipoprotein (HDL) subclasses[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olezarsen sodium Related Antibodies
Molecular Weight

8684.86 (free acid)

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Olezarsen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 96.53%

SDS (252 KB)

COA (247 KB) LCMS (328 KB)

Handling Instructions (2242 KB)
References
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Olezarsen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olezarsen2298451-31-5ISIS 678354IONIS-APOCIII-LRxAKCEA-APOCIII-LRxISIS678354ISIS-678354Apolipoproteintriglyceride-rich lipoprotein particleLDL particlesAPOC3 mRNAplasma triglycerideapolipoprotein Bnon-HDL cholesterolfamilial chylomicronemia syndromeapolipoprotein C-IIIribonuclease H1HDL-PInhibitorinhibitorinhibit

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