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Results for "

Ca2 -ATPase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (27) Calmodulin (2) CaMK (1) Na+/K+ ATPase (5) ABA Receptor (2) Antibiotic (6) Apoptosis (8) Autophagy (7) Bacterial (9) Biochemical Assay Reagents (3) Cholinesterase (ChE) (1) COX (2) Endogenous Metabolite (3) Environmental Pollutants (4) Fungal (7) HCN Channel (2) Isotope-Labeled Compounds (1) Lipoxygenase (2) Myosin (2) NF-κB (1) NO Synthase (1) Oxidative Phosphorylation (5) Parasite (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PKG (2) Potassium Channel (1) Proton Pump (5) Reactive Oxygen Species (ROS) (1) Reference Standards (9) SARS-CoV (1) SOD (2) Sodium Channel (6)
By Research Areas:	Cancer (11) Cardiovascular Disease (13) Infection (11) Inflammation/Immunology (3) Metabolic Disease (14) Neurological Disease (15)

By Targets:

Calcium Channel (27)

Calmodulin (2)

CaMK (1)

Na+/K+ ATPase (5)

ABA Receptor (2)

Antibiotic (6)

Apoptosis (8)

Autophagy (7)

Bacterial (9)

Biochemical Assay Reagents (3)

Cholinesterase (ChE) (1)

COX (2)

Endogenous Metabolite (3)

Environmental Pollutants (4)

Fungal (7)

HCN Channel (2)

Isotope-Labeled Compounds (1)

Lipoxygenase (2)

Myosin (2)

NF-κB (1)

NO Synthase (1)

Oxidative Phosphorylation (5)

Parasite (1)

Phosphodiesterase (PDE) (2)

Phospholipase (1)

PKG (2)

Potassium Channel (1)

Proton Pump (5)

Reactive Oxygen Species (ROS) (1)

Reference Standards (9)

SARS-CoV (1)

SOD (2)

Sodium Channel (6)

By Research Areas:

Cancer (11)

Cardiovascular Disease (13)

Infection (11)

Inflammation/Immunology (3)

Metabolic Disease (14)

Neurological Disease (15)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Calcium Channel CRAC Channel Na+/Ca2+ Exchanger Na+/K+ ATPase CaSR Calmodulin CaMK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13433

Thapsigargin Maximum Cited Publications 138 Publications Verification	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal *Ca ²⁺-ATPase*. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-N6687

Calcimycin 20+ Cited Publications A-23187; Antibiotic A-23187	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .

HY-101455

CDN1163 15+ Cited Publications	Calcium Channel	Metabolic Disease
CDN1163 is an allosteric *sarco/endoplasmic reticulum Ca ²⁺-ATPase* (SERCA)** activator that improves Ca ²⁺ homeostasis. CDN1163 attenuates diabetes and metabolic disorders .

HY-W019981B

Magnesium chloride hexahydrate, for molecular biology MgCl2 hexahydrate, for molecular biology	Calcium Channel Biochemical Assay Reagents	Metabolic Disease
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for molecular biology is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate increases the activity of Ca ²⁺ ATPase .

HY-100560

Abscisic acid 3 Publications Verification (S)-(+)-Abscisic acid; ABA	Environmental Pollutants Endogenous Metabolite ABA Receptor Proton Pump	Metabolic Disease
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H ⁺-ATPase) and leads to the plasma membrane depolarization in a Ca ²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-W019981C

Magnesium chloride hexahydrate, for cell culture MgCl2 hexahydrate, for cell culture	Calcium Channel Biochemical Assay Reagents	Metabolic Disease
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for cell culture is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate, for cell culture can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate, for cell culture increases the activity of Ca ²⁺ ATPase .

HY-103312

Xestospongin C 5+ Cited Publications (-)-Xestospongin C	Calcium Channel Apoptosis	Neurological Disease
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

HY-103319

Calmidazolium chloride 4 Publications Verification R 24571	Autophagy Calmodulin	Neurological Disease Cancer
Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively . Also in anti-cancer research . Calmidazolium binds to calmodulin with a K_d of 3 nM.

HY-114252

Strophanthidin 1 Publications Verification	Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N6778

Paxilline 5+ Cited Publications	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)	Neurological Disease
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-Y0258

Benzocaine 1 Publications Verification	Environmental Pollutants Sodium Channel Bacterial	Infection Neurological Disease
Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-16690

BTS 3 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 µM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

HY-Y0413

Biacetyl monoxime Diacetyl monoxime; DAM	Na+/K+ ATPase Myosin	Cardiovascular Disease Metabolic Disease
Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II. Biacetyl monoxime induces sarcoplasmic reticulum Ca ²⁺ release .

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane *Ca ²⁺-ATPase*, respectively .

HY-P3278

Caloxin 2A1 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-Y0258A

Benzocaine (hydrochloride) 1 Publications Verification	Sodium Channel Calcium Channel	Neurological Disease
Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals .

HY-W012399

2,5-Di-tert-butylhydroquinone	Environmental Pollutants Calcium Channel COX Lipoxygenase	Inflammation/Immunology Cancer
2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a *Sarco/endoplasmic reticulum Ca ²⁺* ATPase (SERCA) inhibitor with an IC₅₀** of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca ²⁺ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC₅₀: 1.8 and 14.1 μM for 5-LO and COX-2, respectively) .

HY-P11292

Caloxin 1b3	Calcium Channel	Cardiovascular Disease
Caloxin 1b3, a peptide, is a selective plasma *membrane Ca ²⁺* pump 1 (PMCA1)** inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca ²⁺–Mg ²⁺-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca ²⁺ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .

HY-15293B

JTV-519 hemifumarate K201 hemifumarate	Calcium Channel	Cardiovascular Disease
JTV-519 hemifumarate (K201 hemifumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-100560R

Abscisic acid (Standard) (S)-(+)-Abscisic acid (Standard); ABA (Standard)	Reference Standards Endogenous Metabolite Proton Pump ABA Receptor	Metabolic Disease
Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-P3278A

Caloxin 2A1 TFA 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-B1726

Phenacaine HoloCaine	Phosphodiesterase (PDE)	Metabolic Disease
Phenacaine (Holocaine) is a local agent that can suppress or relieve pain. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca ²⁺-ATPase and cyclic nucleotide phosphodiesterases from brain and heart .

HY-P10655

Caloxin 1C2	Proton Pump Calcium Channel	Cardiovascular Disease
Caloxin 1C2 is a specific PMCA (plasma-membrane Ca ²⁺-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The K_i values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca ²⁺ transfer. Caloxin 1C2 affects coronary contractility .

HY-N1989

Bacoside A	Na+/K+ ATPase CaMK Apoptosis Cholinesterase (ChE) NO Synthase NF-κB	Neurological Disease Cancer
Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na ⁺/K ⁺-ATPase, Ca ²⁺-ATPase and Mg ²⁺-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme .

HY-124873

SERCA2a activator 1	Calcium Channel	Cardiovascular Disease
SERCA2a activator 1 (Compound A) is a *sarco/endoplasmic reticulum Ca ²⁺-dependent* ATPase 2a (SERCA2a)** activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure .

HY-135110

Rp-8-Br-cGMPS sodium 1 Publications Verification Rp-8-bromo-Cyclic GMPS sodium	Calcium Channel PKG HCN Channel	Metabolic Disease
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca ²⁺-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca ²⁺ reduction by activating Ca ²⁺-ATPase and subsequently removing Ca ²⁺ from the cell .

HY-B1837A

β-Cyfluthrin beta-Cyfluthrin	Environmental Pollutants Calcium Channel SOD	Neurological Disease
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting **Ca ²⁺ ATPase** involved in calcium transport .

HY-W795960

D-myo-Inositol 1,4,5-trisphosphate sodium salt	Biochemical Assay Reagents Calcium Channel Phospholipase	Neurological Disease Metabolic Disease
D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and *Ca ²⁺-ATPase* activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

HY-W010710

IPrAuCl	Calcium Channel	Cardiovascular Disease
IPrAuCl (compound 3) is a gold compound. IPrAuCl inhibits sarcoplasmic reticulum *Ca ²⁺-ATPase* (IC₅₀=16.3 µM) .

HY-15293

JTV-519 K201	Calcium Channel	Cardiovascular Disease
JTV-519 (K201) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-110312

JTV-519 fumarate K201 fumarate	Calcium Channel	Cardiovascular Disease
JTV-519 fumarate (K201 fumarate) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. JTV-519 fumarate is a cardioprotective agent with antiarrhythmic effects .

HY-18051

CXL 017	Calcium Channel	Cancer
CXL 017 is a sarco/endoplasmic reticulum Ca ²⁺-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia .

HY-Y0258R

Benzocaine (Standard) 1 Publications Verification	Reference Standards Sodium Channel Bacterial	Neurological Disease
Benzocaine (Standard) is the analytical standard of Benzocaine (HY-Y0258). This product is intended for research and analytical applications. Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-B1837AR

β-Cyfluthrin (Standard) beta-Cyfluthrin (Standard)	Reference Standards Calcium Channel SOD	Neurological Disease
β-Cyfluthrin (Standard) is the analytical standard of β-Cyfluthrin. This product is intended for research and analytical applications. β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting **Ca ²⁺ ATPase** involved in calcium transport .

HY-N6687B

Calcimycin hemimagnesium A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium	Oxidative Phosphorylation Antibiotic Bacterial Fungal Apoptosis Autophagy	Infection Cancer
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis and autophagy .

HY-114252R

Strophanthidin (Standard)	Reference Standards Na+/K+ ATPase	Cardiovascular Disease
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-138035

Tenellin	Fungal	Infection
Tenellin is a fungal metabolite that has been found in Beauveria. It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/mL.1 Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of- 4.84 and 11.95 μM, respectively.

HY-101455R

CDN1163 (Standard)	Calcium Channel Reference Standards	Metabolic Disease
CDN1163 (Standard) is the analytical standard of CDN1163 (HY-101455). This product is intended for research and analytical applications. CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders .

HY-135110A

Rp-8-Br-cGMPS Rp-8-bromo-Cyclic GMPS	Calcium Channel PKG HCN Channel	Metabolic Disease
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca ²⁺-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca ²⁺ reduction by activating Ca ²⁺-ATPase and subsequently removing Ca ²⁺ from the cell .

HY-P6008

Myoregulin MLN peptide	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P6008A

Myoregulin TFA MLN peptide TFA	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) TFA is a member of the regulin family. Myoregulin TFA regulates muscle performance by modulating intracellular calcium handling. Myoregulin TFA interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-15293A

JTV-519 free base K201 free base	Calcium Channel	Cardiovascular Disease
JTV-519 free base (K201 free base) is a Ca ²⁺-dependent blocker of sarcoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties .

HY-100981

MR-16728 hydrochloride	Endogenous Metabolite	Neurological Disease
MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins .

HY-Y0258S

Benzocaine-d4	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Benzocaine-d₄ is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-Y0258S1

Benzocaine-(ethyl-d5)	Sodium Channel	Neurological Disease
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-Y0258AR

Benzocaine (hydrochloride) (Standard)	Reference Standards Bacterial Sodium Channel	Neurological Disease
Benzocaine hydrochloride (Standard) is an analytical standard of Benzocaine hydrochloride (HY-Y0258A). This product is intended for research and analytical applications. Benzocaine hydrochloride is an orally active local anesthetic. Benzocaine hydrochloride non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with a IC₅₀ of 47.1 mM. Benzocaine hydrochloride exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine hydrochloride induces methemoglobinemia in various experimental animals .

HY-N6687R

Calcimycin (Standard) A-23187 (Standard); Antibiotic A-23187 (Standard)	Oxidative Phosphorylation Reference Standards Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (Standard) is the analytical standard of Calcimycin. This product is used for research and analytical applications. Calcimycin is an antibiotic and a unique divalent cation ionophore, such as calcium ions and magnesium ions. Calcimycin induces Ca ²⁺ -dependent cell death by increasing the intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and uncouples the oxidative phosphorylation (OXPHOS) of mammalian cells, inducing apoptosis and autophagy.

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemiCalcium salt; Antibiotic A-23187 hemiCalcium salt	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic	Infection Cancer
Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy .

HY-W012399R

2,5-Di-tert-butylhydroquinone (Standard)	Reference Standards Calcium Channel Lipoxygenase COX	Inflammation/Immunology
2,5-Di-tert-butylhydroquinone (Standard) is the analytical standard of 2,5-Di-tert-butylhydroquinone. This product is intended for research and analytical applications. 2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a *Sarco/endoplasmic reticulum Ca ²⁺* ATPase (SERCA) inhibitor with an IC₅₀** of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca ²⁺ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC₅₀: 1.8 and 14.1 μM for 5-LO and COX-2, respectively) .

HY-103319R

Calmidazolium chloride (Standard) R 24571 (Standard)	Reference Standards Autophagy Calmodulin	Neurological Disease Cancer
Calmidazolium chloride (Standard) is the analytical standard of Calmidazolium chloride (HY-103319). This product is intended for research and analytical applications. Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively . Also in anti-cancer research . Calmidazolium binds to calmodulin with a K_d of 3 nM.

Cat. No.	Product Name	Type

HY-W019981B

Magnesium chloride hexahydrate, for molecular biology MgCl2 hexahydrate, for molecular biology	Biochemical Assay Reagents
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for molecular biology is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate increases the activity of Ca ²⁺ ATPase .

HY-W019981C

Magnesium chloride hexahydrate, for cell culture MgCl2 hexahydrate, for cell culture	Biochemical Assay Reagents
Magnesium chloride hexahydrate (MgCl₂ hexahydrate), for cell culture is the hexahydrate form of magnesium dichloride. Magnesium chloride hexahydrate, for cell culture can be used as a source of magnesium ion and a co-foactor for many enzymes. Magnesium chloride hexahydrate, for cell culture increases the activity of Ca ²⁺ ATPase .

HY-W795960

D-myo-Inositol 1,4,5-trisphosphate sodium salt

Biochemical Assay Reagents

D-myo-inositol 1,4,5-trisphosphate sodium salt is a widely distributed intracellular second messenger. D-myo-inositol 1,4,5-trisphosphate sodium salt acts as a potent agonist of the Ins (1,4,5) P₃ receptor with an EC₅₀ of 0.12 μM and inhibits bovine PLC-δ1, with an IC₅₀ of 5.4 μM for binding and an IC₅₀ of 12.4 μM for hydrolysis. D-myo-inositol 1,4,5-trisphosphate sodium saltis metabolized into Ins (1,4) P₂ and Ins (1,3,4,5) P₄. D-myo-inositol 1,4,5-trisphosphate sodium salt mediates various cellular processes, including growth, development, fertilization, secretion, contraction and neuromodulation. D-myo-inositol 1,4,5-trisphosphate sodium salt inhibits PIP₂ hydrolysis and Ca ²⁺-ATPase activity. D-myo-inositol 1,4,5-trisphosphate sodium salt is used for cardiac preconditioning, exerts cardioprotective effects and mimics ischemic preconditioning. D-myo-inositol 1,4,5-trisphosphate sodium salt is applied in studies related to intracellular calcium and phosphoinositol signaling pathways .

Cat. No.	Product Name	Target	Research Area

HY-P5712

Gramicidin S 1 Publications Verification Gramicidin soviet	Antibiotic Bacterial Na+/K+ ATPase	Infection
Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC₅₀s of 41 μM, 24 μM, and 3 μM for Na ⁺/K ⁺-ATPase, tobacco leaf plasma membrane Mg ²⁺/K ⁺-ATPase, and rat heart plasma membrane *Ca ²⁺-ATPase*, respectively .

HY-P3278

Caloxin 2A1 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P11292

Caloxin 1b3	Calcium Channel	Cardiovascular Disease
Caloxin 1b3, a peptide, is a selective plasma *membrane Ca ²⁺* pump 1 (PMCA1)** inhibitor. Caloxin 1b3 significantly inhibits PMCA1 Ca ²⁺–Mg ²⁺-ATPase in the rabbit duodenal mucosa than the PMCA4 in the human erythrocyte ghosts. Caloxin 1b3 also increases cytosolic Ca ²⁺ concentration in endothelial cells. Caloxin 1b3 can be used for cardiovascular disorders research .

HY-P3278A

Caloxin 2A1 TFA 2 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular *plasma membrane Ca ²⁺-ATPase* (PMCA)** peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-P10655

Caloxin 1C2	Proton Pump Calcium Channel	Cardiovascular Disease
Caloxin 1C2 is a specific PMCA (plasma-membrane Ca ²⁺-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The K_i values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca ²⁺ transfer. Caloxin 1C2 affects coronary contractility .

HY-P6008

Myoregulin MLN peptide	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) is a member of the regulin family. Myoregulin regulates muscle performance by modulating intracellular calcium handling. Myoregulin interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P6008A

Myoregulin TFA MLN peptide TFA	Calcium Channel	Cardiovascular Disease
Myoregulin (MLN peptide) TFA is a member of the regulin family. Myoregulin TFA regulates muscle performance by modulating intracellular calcium handling. Myoregulin TFA interactes directly with sarcoplasmic reticulum Ca ²⁺-ATPase (SERCA) and impedinf Ca ²⁺ uptake into the sarcoplasmic reticulum .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin *Ca ²⁺-ATPase*. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13433

Thapsigargin Maximum Cited Publications 138 Publications Verification	Infection Classification of Application Fields Terpenoids Diterpenoids Umbelliferae Plants Disease Research Fields Source Classification Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal *Ca ²⁺-ATPase*. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-N6687

Calcimycin 20+ Cited Publications A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .

HY-100560

Abscisic acid 3 Publications Verification (S)-(+)-Abscisic acid; ABA	Structural Classification Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Agricultural Research Microorganisms other families Animals Terpenoids Sesquiterpenes Abscisic acid Phytohormone Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite ABA Receptor Proton Pump
Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H ⁺-ATPase) and leads to the plasma membrane depolarization in a Ca ²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-103312

Xestospongin C 5+ Cited Publications (-)-Xestospongin C	Alkaloids Piperidine Alkaloids Animals Source Classification	Calcium Channel Apoptosis
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells .

HY-114252

Strophanthidin 1 Publications Verification	Cardiovascular Disease Classification of Application Fields Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn. Source Classification	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Indole Alkaloids Source Classification	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-100560R

Abscisic acid (Standard) (S)-(+)-Abscisic acid (Standard); ABA (Standard)	Structural Classification Microorganisms other families Animals Terpenoids Sesquiterpenes Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Proton Pump ABA Receptor
Abscisic acid (Standard) is the analytical standard of Abscisic acid. This product is intended for research and analytical applications. Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H+-ATPase) and leads to the plasma membrane depolarization in a Ca2+-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome .

HY-N1989

Bacoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Scrophulariaceae Metabolic Disease Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Source Classification	Na+/K+ ATPase CaMK Apoptosis Cholinesterase (ChE) NO Synthase NF-κB
Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na ⁺/K ⁺-ATPase, Ca ²⁺-ATPase and Mg ²⁺-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme .

HY-114252R

Strophanthidin (Standard)	Structural Classification Plants Brassicaceae Steroids Erysimum cheiranthoides Linn. Source Classification	Reference Standards Na+/K+ ATPase
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-N6687R

Calcimycin (Standard) A-23187 (Standard); Antibiotic A-23187 (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Polyether Antibiotics Source Classification	Oxidative Phosphorylation Reference Standards Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (Standard) is the analytical standard of Calcimycin. This product is used for research and analytical applications. Calcimycin is an antibiotic and a unique divalent cation ionophore, such as calcium ions and magnesium ions. Calcimycin induces Ca ²⁺ -dependent cell death by increasing the intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and uncouples the oxidative phosphorylation (OXPHOS) of mammalian cells, inducing apoptosis and autophagy.

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemiCalcium salt; Antibiotic A-23187 hemiCalcium salt	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy .

HY-N18431

Stellettamide A TFA ST-A TFA	Structural Classification Polysaccharides Iridoids Terpenoids Marine algae Marine natural products Sponge Saccharides Source Classification	Fungal
Stellettamide A TFA is a marine toxin found in a marine sponge. Stellettamide A TFA is a calmodulin inhibitor. Stellettamide A TFA can inhibit Ca ²⁺/Mg ²⁺ ATPase, phosphodiesterase, myosin light chain , and Mg ²⁺-ATPase. Stellettamide A TFA inhibits high K ⁺- and Ca ²⁺-induced contraction in permeabilized smooth muscle. Stellettamide A TFA exhibits antifungal activity against Mortierella remannianus. Stellettamide A TFA can be used for the research of fungal infection .

HY-N18114

rel-(E)-6,7-Transdihydroxyligustilide	Structural Classification Polygonaceae Other Phenylpropanoids Phenylpropanoids Fallopia multiflora (Thunb.) Harald. Plants Source Classification	Calcium Channel
rel-(E)-6,7-Transdihydroxyligustilide is a compound found in the dried tuberous roots of Polygonum multiflorum. rel-(E)-6,7-Transdihydroxyligustilide inhibits *Ca ²⁺‑ATPase* in calmodulin-deficient human erythrocyte membranes. rel-(E)-6,7-Transdihydroxyligustilide is used for the research of hyperlipidemia .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Structural Classification Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Source Classification	Parasite Phosphodiesterase (PDE)
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin *Ca ²⁺-ATPase*. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

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HY-P704183

	ATP2A1 Protein, Human (Cell-Free, His) SERCa1; SR Ca2+; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca2+	Human	E. coli Cell-free
	ATP2A1 is critical for striated muscle function, acting as the primary Ca(2+) ATPase to efficiently reuptake cytosolic Ca(2+) into the sarcoplasmic reticulum. Through ATP hydrolysis, ATP2A1 transfers calcium from the cytoplasm to the sarcoplasmic reticulum lumen, which is critical for precise control of calcium levels, regulation of isolation, and control of muscle excitation and contraction dynamics. ATP2A1 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP2A1 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-Y0258S

Benzocaine-d4
Benzocaine-d₄ is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

HY-Y0258S1

Benzocaine-(ethyl-d5)
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca ²⁺, with an IC₅₀ of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2)
Application:	IHC-P (2) ICC/IF (2) IHC-F (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P82186

	*SERCA2 ATPase* Antibody (YA1931)** ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum Calcium ATPase 2; SERCa2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SERCA2 ATPase.

HY-P82186A

	*SERCA2 ATPase* Antibody (YA1931)(PBS only)** ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum Calcium ATPase 2; SERCa2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	SERCA2 ATPase Antibody (YA1931) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SERCA2 ATPase.

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Ca2 -ATPase

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