Benzocaine-d4
Based on 1 Customer Validation
Benzocaine-d4 is the deuterium labeled Benzocaine (HY-Y0258). Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca2+, with an IC50 of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals.
For research use only. We do not sell to patients.
- Purity: 99.34%
- CAS No.: 342611-08-9
- Formula: C9H7D4NO2
- Molecular Weight:169.21
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 342611-08-9
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Unlabeled Cas 94-09-7
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Appearance Solid
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Molecular Weight 169.21
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Formula C9H7D4NO2
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Color White to off-white
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SMILES
CCOC(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (590.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302. [Content Brief]
[3]. Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6. [Content Brief]
[4]. Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9098 mL | 29.5491 mL | 59.0982 mL | 147.7454 mL |
| 5 mM | 1.1820 mL | 5.9098 mL | 11.8196 mL | 29.5491 mL | |
| 10 mM | 0.5910 mL | 2.9549 mL | 5.9098 mL | 14.7745 mL | |
| 15 mM | 0.3940 mL | 1.9699 mL | 3.9399 mL | 9.8497 mL | |
| 20 mM | 0.2955 mL | 1.4775 mL | 2.9549 mL | 7.3873 mL | |
| 25 mM | 0.2364 mL | 1.1820 mL | 2.3639 mL | 5.9098 mL | |
| 30 mM | 0.1970 mL | 0.9850 mL | 1.9699 mL | 4.9248 mL | |
| 40 mM | 0.1477 mL | 0.7387 mL | 1.4775 mL | 3.6936 mL | |
| 50 mM | 0.1182 mL | 0.5910 mL | 1.1820 mL | 2.9549 mL | |
| 60 mM | 0.0985 mL | 0.4925 mL | 0.9850 mL | 2.4624 mL | |
| 80 mM | 0.0739 mL | 0.3694 mL | 0.7387 mL | 1.8468 mL | |
| 100 mM | 0.0591 mL | 0.2955 mL | 0.5910 mL | 1.4775 mL |
Benzocaine-d4 Related Classifications
HY-Y0258S Related Classifications
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