Caloxin 2A1 TFA

Name: Caloxin 2A1 TFA
Brand: MedChemExpress
SKU: HY-P3278A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3278A Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

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Caloxin 2A1 TFA is an extracellular plasma membrane Ca²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Caloxin 2A1 TFA Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Caloxin 2A1 TFA:

Caloxin 2A1 Get quote

1 Publications Citing Use of MCE Caloxin 2A1 TFA

•Adv Funct Mater. 2023 Mar 14.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Caloxin 2A1 TFA is an extracellular plasma membrane Ca²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase^[1].

In Vitro

Caloxin 2A1 TFA inhibits Ca²⁺-Mg²⁺-ATPase in human erythrocyte leaky ghosts, but it does not affect basal Mg²⁺-ATPase or Na⁺-K⁺-ATPase in the ghosts or Ca²⁺-Mg²⁺-ATPase in the skeletal muscle sarcoplasmic reticulum. Caloxin 2A1 TFA also inhibits Ca²⁺-dependent formation of the 140-kDa acid-stable acylphosphate^[1].
Caloxin 2A1 TFA increases airway smooth muscle cells (ASMCs) apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1592.54

Formula

C₆₆H₉₂F₃N₁₉O₂₄

Appearance

Solid

Color

White to off-white

Sequence Shortening

VSNSNWPSFPSSGGG-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (62.79 mM; Need ultrasonic)

DMSO : 100 mg/mL (62.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6279 mL	3.1396 mL	6.2793 mL
5 mM	0.1256 mL	0.6279 mL	1.2559 mL
10 mM	0.0628 mL	0.3140 mL	0.6279 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (1.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (1.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (249 KB) LCMS (87 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. J Chaudhary, et al. Caloxin: a novel plasma membrane Ca2+ pump inhibitor. Am J Physiol Cell Physiol. 2001 Apr;280(4):C1027-30. [Content Brief]

[2]. Yi-fei Chen, et al. Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and the proliferation of airway smooth muscle cells. Eur J Pharmacol. 2014 Oct 5;740:733-41. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.6279 mL	3.1396 mL	6.2793 mL	15.6982 mL
	5 mM	0.1256 mL	0.6279 mL	1.2559 mL	3.1396 mL
	10 mM	0.0628 mL	0.3140 mL	0.6279 mL	1.5698 mL
	15 mM	0.0419 mL	0.2093 mL	0.4186 mL	1.0465 mL
	20 mM	0.0314 mL	0.1570 mL	0.3140 mL	0.7849 mL
	25 mM	0.0251 mL	0.1256 mL	0.2512 mL	0.6279 mL
	30 mM	0.0209 mL	0.1047 mL	0.2093 mL	0.5233 mL
	40 mM	0.0157 mL	0.0785 mL	0.1570 mL	0.3925 mL
	50 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.3140 mL
	60 mM	0.0105 mL	0.0523 mL	0.1047 mL	0.2616 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Caloxin 2A1 TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caloxin 2A1Proton PumpplasmamembraneCa2+peptideacylphosphateInhibitorinhibitorinhibit

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Caloxin 2A1 TFA

Customer Review

Other Forms of Caloxin 2A1 TFA:

Caloxin 2A1 TFA Related Antibodies

1 Publications Citing Use of MCE Caloxin 2A1 TFA

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•Related Screening Libraries:

•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review

Caloxin 2A1 TFA Related Antibodies

Molarity Calculator

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Complete Stock Solution Preparation Table

Caloxin 2A1 TFA Related Classifications

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