Rp-8-Br-cGMPS
Based on 1 publication(s) in Google Scholar
Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca2+ reduction by activating Ca2+-ATPase and subsequently removing Ca2+ from the cell.
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- CAS No.: 150418-07-8
- Formula: C10H11BrN5O6PS
- Molecular Weight:440.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Rp-8-Br-cGMPS
MoreAll Calcium Channel Isoforms
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Biological Activity
Chemical Information
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CAS No. 150418-07-8
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Molecular Weight 440.17
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Formula C10H11BrN5O6PS
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S)=O)O3)C(Br)=N2)NC(N)=N1
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Synonyms
Rp-8-bromo-Cyclic GMPS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Antioxid Redox Signal
Exosomal Prolactin-Induced Protein Inhibits the Activation of cGMP/PKG Pathway Mediated by ATP2B2 to Promote Myocardial Fibrosis in Atrial Fibrillation. [Abstract]2025 Jul;43(1-3):14-36. PMID: 40094760
Purity & Documentation
References
[1]. Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5685-9. [Content Brief]
[2]. Barnstable CJ, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov;45(6):875-84. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rp-8-Br-cGMPS Related Classifications
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