1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. JTV-519 hemifumarate

JTV-519 hemifumarate (Synonyms: K201 hemifumarate)

Cat. No.: HY-15293B
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JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.

For research use only. We do not sell to patients.

JTV-519 hemifumarate Chemical Structure

JTV-519 hemifumarate Chemical Structure

CAS No. : 1435938-25-2

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Description

JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2].

In Vitro

JTV-519 (K201) inhibits inward Ca2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca2+, 3 μM JTV-519 shows significant inhibition of Ca2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201[2].

In Vivo

JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment[3].

Animal Model: Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) [3]
Dosage: 0.5 mg/kg/h
Administration: Applied intraperitoneally 2 h before the surgery
Result: Improved cardiac function, where the EF and FS were significantly increased.
Molecular Weight

482.64

Formula

C₂₅H₃₂N₂O₂S.₁/₂C₄H₄O₄

CAS No.

1435938-25-2

SMILES

O=C(N1CCSC2=CC=C(OC)C=C2C1)CCN3CCC(CC4=CC=CC=C4)CC3.O=C(O)/C=C/C(O)=O.[1/2]

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JTV-519 hemifumarateK201 hemifumarateCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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JTV-519 hemifumarate
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