2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. JTV-519 hemifumarate

JTV-519 hemifumarate  (Synonyms: K201 hemifumarate)

Cat. No.: HY-15293B Purity: 98.69%
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JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.

For research use only. We do not sell to patients.

JTV-519 hemifumarate Chemical Structure

JTV-519 hemifumarate Chemical Structure

CAS No. : 1435938-25-2

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Based on 1 publication(s) in Google Scholar

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JTV-519 hemifumarate Related Antibodies

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Description

JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2].

In Vitro

JTV-519 (K201) inhibits inward Ca2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca2+, 3 μM JTV-519 shows significant inhibition of Ca2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JTV-519 hemifumarate Related Antibodies
In Vivo

JTV-519 (0.5mg/kg/h, i.v., 2 h before the surgery) improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type male C57BL/6 mice weighing 18-22g with polymicrobial sepsis produced by cecal ligation and puncture (CLP) [3]
Dosage: 0.5 mg/kg/h
Administration: Applied intraperitoneally 2 h before the surgery
Result: Improved cardiac function, where the EF and FS were significantly increased.
Clinical Trial
Molecular Weight

482.64

Formula

C25H32N2O2S.1/2C4H4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCSC2=CC=C(OC)C=C2C1)CCN3CCC(CC4=CC=CC=C4)CC3.O=C(O)/C=C/C(O)=O.[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0719 mL 10.3597 mL 20.7194 mL
5 mM 0.4144 mL 2.0719 mL 4.1439 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0719 mL 10.3597 mL 20.7194 mL 51.7984 mL
5 mM 0.4144 mL 2.0719 mL 4.1439 mL 10.3597 mL
10 mM 0.2072 mL 1.0360 mL 2.0719 mL 5.1798 mL
15 mM 0.1381 mL 0.6906 mL 1.3813 mL 3.4532 mL
20 mM 0.1036 mL 0.5180 mL 1.0360 mL 2.5899 mL
25 mM 0.0829 mL 0.4144 mL 0.8288 mL 2.0719 mL
30 mM 0.0691 mL 0.3453 mL 0.6906 mL 1.7266 mL
40 mM 0.0518 mL 0.2590 mL 0.5180 mL 1.2950 mL
50 mM 0.0414 mL 0.2072 mL 0.4144 mL 1.0360 mL
60 mM 0.0345 mL 0.1727 mL 0.3453 mL 0.8633 mL
80 mM 0.0259 mL 0.1295 mL 0.2590 mL 0.6475 mL
100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.5180 mL
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JTV-519 hemifumarate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JTV-519 hemifumarate1435938-25-2K201 hemifumarateCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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