1435938-25-2
1435938-25-2
Chemical Structure
JTV-519 hemifumarate
Synonym(s): K201 hemifumarate
- CAS No.: 1435938-25-2
- Formula:C25H32N2O2S.1/2C4H4O4
- Molecular Weight:482.64
SMILES: O=C(N1CCSC2=CC=C(OC)C=C2C1)CCN3CCC(CC4=CC=CC=C4)CC3.O=C(O)/C=C/C(O)=O.[1/2]
Biological Activity: JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JTV-519 hemifumarate | 99.74% | JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. | ||||||||||||||||||||
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References
- [1]. Darcy YL, et al. K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle. Mol Pharmacol. 2016 Aug;90(2):106-15. [Content Brief]
- [2]. Kaneko N, et al. Inhibition of annexin V-dependent Ca2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazepine derivative. Biochim Biophys Acta. 1997 Nov 13;1330(1):1-7. [Content Brief]
