SERCA2a activator 1
Based on 1 Customer Validation
SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure.
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 2139330-34-8
- Formula: C32H29N3O4S
- Molecular Weight:551.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SERCA2a[1]
SERCA2a activator 1 (Compound A) activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum (SR) vesicles but not that of skeletal muscle SR vesicles that lack phospholamban (PLN). The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation[1].
SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. In isolated perfused rat hearts, the SERCA2a activator 1 enhances systolic and diastolic functions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (7-8 weeks old)[1]
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Dosage:30mg/kg
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Administration:Intravenous injection
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Result:Significantly enhanced the diastolic function in anesthetized normal rats.
Chemical Information
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CAS No. 2139330-34-8
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Appearance Solid
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Molecular Weight 551.66
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Formula C32H29N3O4S
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Color Light yellow to yellow
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SMILES
O=C(C1=CC(C(C=C2CC3=CC=CC=C3)=CN(CCCC)C2=O)=NC=C1)NS(=O)(C4=CC=C5C=CC=CC5=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (113.29 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8127 mL | 9.0636 mL | 18.1271 mL | 45.3178 mL |
| 5 mM | 0.3625 mL | 1.8127 mL | 3.6254 mL | 9.0636 mL | |
| 10 mM | 0.1813 mL | 0.9064 mL | 1.8127 mL | 4.5318 mL | |
| 15 mM | 0.1208 mL | 0.6042 mL | 1.2085 mL | 3.0212 mL | |
| 20 mM | 0.0906 mL | 0.4532 mL | 0.9064 mL | 2.2659 mL | |
| 25 mM | 0.0725 mL | 0.3625 mL | 0.7251 mL | 1.8127 mL | |
| 30 mM | 0.0604 mL | 0.3021 mL | 0.6042 mL | 1.5106 mL | |
| 40 mM | 0.0453 mL | 0.2266 mL | 0.4532 mL | 1.1329 mL | |
| 50 mM | 0.0363 mL | 0.1813 mL | 0.3625 mL | 0.9064 mL | |
| 60 mM | 0.0302 mL | 0.1511 mL | 0.3021 mL | 0.7553 mL | |
| 80 mM | 0.0227 mL | 0.1133 mL | 0.2266 mL | 0.5665 mL | |
| 100 mM | 0.0181 mL | 0.0906 mL | 0.1813 mL | 0.4532 mL |
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