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Isoforms Recommended:	CK1

Results for "

ck1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Creatine Kinase (1) Adenosine Kinase (2) Akt (1) Amyloid-β (1) Apoptosis (11) Autophagy (3) Bcl-2 Family (1) Biochemical Assay Reagents (1) c-Myc (1) Casein Kinase (99) CDK (10) Checkpoint Kinase (Chk) (2) CMV (1) E3 Ligase Ligand-Linker Conjugates (1) Early 2 Factor (E2F) (1) ERK (1) Flavivirus (1) FLT3 (1) Glucose-6-Phosphate Isomerase (GPI) (1) GSK-3 (3) IKZF Family (6) LDLR (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) MALT1 (1) MDM-2/p53 (4) MEK (1) Molecular Glues (15) mTOR (1) NF-κB (1) p38 MAPK (10) Phosphodiesterase (PDE) (2) PI3K (8) PKC (1) Porcupine (1) PROTACs (3) Reference Standards (7) Ribosomal S6 Kinase (RSK) (2) SGK (2) Small Interfering RNA (siRNA) (3) VEGFR (1) Virus Protease (1) VRK (1) Wee1 (2) Wnt (13) β-catenin (1)
By Research Areas:	Cancer (74) Cardiovascular Disease (5) Infection (3) Inflammation/Immunology (10) Metabolic Disease (3) Neurological Disease (29)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

118

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

GMP Molecules

Targets Recommended: Creatine Kinase Choline Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13912

IWP-2 Maximum Cited Publications 31 Publications Verification	Wnt Porcupine Casein Kinase	Cancer
IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive *CK1δ* inhibitor with an IC₅₀ of 40 nM for the gatekeeper mutant ^M82FCK1δ ^[1] .

HY-15424

5-Iodotubercidin 10+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin ^[1] .

HY-10324

D4476 10+ Cited Publications Casein Kinase I Inhibitor	Casein Kinase Autophagy Apoptosis	Cancer
D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC₅₀ value of 0.3 μM in vitro.

HY-15490

PF-670462 dihydrochloride 5+ Cited Publications	Casein Kinase	Cancer
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC₅₀s of 7.7 nM and 14 nM, respectively.

HY-18340

(R)-CR8 1 Publications Verification CR8, (R)-Isomer	Molecular Glues CDK Apoptosis	Neurological Disease Cancer
(R)-CR8, a second-generation analog of Roscovitine, is a potent *CDK1/2/5/7/9* inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC₅₀=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect ^[1] . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .

HY-10456

TAK-715 10+ Cited Publications	p38 MAPK Casein Kinase Wnt	Inflammation/Immunology
TAK-715 is an orally active and potent p38 MAPK inhibitor with IC₅₀s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model ^[1] .

HY-123954

BTX-A51 1 Publications Verification Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities ^[1].

HY-12470

PF-4800567 2 Publications Verification	Casein Kinase	Others
PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC₅₀ of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC₅₀, 711 nM).

HY-111820

CK1-IN-1	Casein Kinase p38 MAPK	Cardiovascular Disease
CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC₅₀ values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC₅₀ of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis ^[1].

HY-W011109

CKI-7 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases ^[1] .

HY-160444

SJ3149 1 Publications Verification	Molecular Glues Casein Kinase	Cancer
SJ3149 is a selective and potent molecular glue degrader of *CK1α* protein with broad antiproliferative activity. SJ3149 can be used in cancer research ^[1] .

HY-159646

BMS-986397	Molecular Glues Ligands for E3 Ligase Casein Kinase Apoptosis MDM-2/p53	Inflammation/Immunology Cancer
BMS-986397 is a potent, selective, and orally active cereblon-based molecular glue degrader of casein kinase 1α (CK1α). BMS-986397 induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. BMS-986397 is a promising agent for the investigation of AML and high-risk myelodysplastic syndromes (HR-MDS) ^[1] .

HY-12774

IC261 4 Publications Verification	Casein Kinase Apoptosis	Cancer
IC261 is a selective, ATP-competitive *CK1* inhibitor, with IC₅₀s of 1 μM, 1 μM, 16 μM for Ckiδ, Ckiε and Ckiα1, respectively.

HY-12879

IWP-4 2 Publications Verification	Wnt Casein Kinase	Cardiovascular Disease Neurological Disease Cancer
IWP-4 is a Wnt inhibitor with an IC₅₀ of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC₅₀ of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC₅₀ = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure ^[1] .

HY-12443

PF-5006739	Casein Kinase	Neurological Disease
PF-5006739 is a potent and selective inhibitor of *CK1δ/ε* with IC₅₀s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner ^[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity .

HY-100114

TA-01	Casein Kinase p38 MAPK Autophagy	Cardiovascular Disease
TA-01 is a potent *CK1* and p38 MAPK inhibitor, with IC₅₀s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. TA-01 acts as a cardiogenic inhibitor.

HY-18285

Longdaysin	Wnt Casein Kinase ERK CDK	Cancer
Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits *CK1α, CK1δ, CDK7, and ERK2* with IC₅₀s of 5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively ^[1] .

HY-158975

*VRK1/CK1-IN-1*	Casein Kinase VRK	Cancer
VRK1/CK1-IN-1 (compound 36) is a dual *VRK1* and *CK1* family inhibitor, with a K_i of 37.9 nM against human *VRK1, 8.3 nM against human CK1δ, and 7.8 nM against human CK1ε. VRK1/CK1-IN-1* exhibits extremely low activity against VRK2. VRK1/CK1-IN-1 can be used in studies related to p53-deficient tumors ^[1].

HY-133028

CKI-7 free base 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases ^[1] .

HY-145322

TMX-4116	Casein Kinase Molecular Glues	Cancer
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC₅₀s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma ^[1].

HY-114858

Epiblastin A 1 Publications Verification	Casein Kinase	Cancer
Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC₅₀s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1 ^[1].

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical Wnt signaling with an IC₅₀ of 1.17μM ^[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth ^[1].

HY-110052

TBCA 1 Publications Verification	Casein Kinase	Cancer
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC₅₀ of 110 nM and a K_i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases ^[1] .

HY-153866

CK1-IN-2	Casein Kinase	Cancer
CK1-IN-2 (compound Nr.4) is a potent *CK1* inhibitor with an IC₅₀ values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively ^[1].

HY-100011

SR-3029 2 Publications Verification	Casein Kinase	Cancer
SR-3029 is a potent and ATP competitive *CK1δ* and *CK1ε* inhibitor, with IC₅₀s of 44 nM and 260 nM, respectively, and K_is of 97 nM for both kinases.

HY-145939

BAY-888 BRD5846	Casein Kinase	Cancer
BAY-888 is a selective *CK1α/CSNK1A1* (casein kinase 1α) ATP-competitive inhibitor (IC₅₀: 4 nM@10 μM ATP; 63 nM@1 mM ATP). BAY-888 blocks the negative regulation of p53 and other signaling pathways by CK1α, induces apoptosis and inhibits proliferation of tumor cells. BAY-888 has shown inhibitory efficacy against cancers such as acute myeloid leukemia (AML) in PRISM barcoded cell line screening and can mimic the effects of shRNA-mediated CK1α knockdown. BAY-888 is primarily used for the development of anticancer drugs for p53 wild-type tumors and for the study of the mechanisms of CK1α-related signaling pathways ^[1] .

HY-172931

DEG-35	Molecular Glues Casein Kinase IKZF Family	Cancer
DEG-35 is a CRBN-dependent, dual IKZF2 and *CK1α* molecule glue degrader, with DC₅₀ values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. DEG-35 activates the p53 apoptosis pathway. DEG-35 can be used in the research for Acute Myeloid Leukemia (AML) ^[1].

HY-120675

SSTC3 2 Publications Verification	Casein Kinase Wnt	Cancer
SSTC3 is a casein kinase 1α (CK1α) activator (K_d = 32 nM) that inhibits WNT signaling (EC₅₀ = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors ^[1].

HY-145319

FPFT-2216	Phosphodiesterase (PDE) Casein Kinase Molecular Glues	Inflammation/Immunology Cancer
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease ^[1] .

HY-148251

MU1742	Casein Kinase	Cancer
MU1742 is a probe for *CK1δ* and *CK1ε* protein kinases ^[1].

HY-100536

IWP-3	Wnt	Cancer
IWP-3 is an potent inhibitor of Wnt production with an IC₅₀ of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α ^[1] .

HY-121944

Ricinine	Casein Kinase Wnt	Others
Ricinine exhibits hepatoprotection in CCl4-induced liver damage. Ricinine is also a *CK1α* inhibitor, and may activate Wnt pathway ^[1] .

HY-148455

Casein kinase 1δ-IN-3	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-3 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC₅₀ of 6.5376 M ^[1].

HY-170859

AH078	PROTACs Casein Kinase	Cancer
AH078 is a PROTAC-based *CK1δ/ε* degrader (DC₅₀=0.55 μM, D_max=70%) that lacks subtype selectivity between *CK1δ* and *CK1ε. AH078 induces target protein degradation either by recruiting the CUL4-CRBN E3* ligase complex and proteasome, or via the VHL- and ubiquitin-dependent pathway. AH078 also exhibits selectivity for *CK1α*, and is widely applicable to research related to colon cancer, pancreatic cancer, breast cancer, ovarian cancer, chronic lymphocytic leukemia, acute myeloid leukemia, glioma, and metastatic breast adenocarcinoma ^[1] .

HY-145320

TMX-4113	Molecular Glues Phosphodiesterase (PDE) Casein Kinase	Cancer
TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer ^[1].

HY-174371

INNO-220	Molecular Glues Casein Kinase MDM-2/p53 MALT1	Neurological Disease Cancer
INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting *CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1* complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research.

HY-123955

Casein Kinase inhibitor A86	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities ^[1].

HY-117857

MRT00033659	Casein Kinase Checkpoint Kinase (Chk) MDM-2/p53 Early 2 Factor (E2F)	Cancer
MRT00033659 is a potent broad-spectrum kinase inhibitor of *CK1* (IC₅₀=0.9 μM for CK1δ) and *CHK1* (IC₅₀=0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation ^[1].

HY-170953

QXG-6442	Casein Kinase Molecular Glues	Cancer
QXG-6442 is a *CK1α* Molecular Glue Degrader. QXG-6442 exhibits *CK1α* degradation potency with a DC₅₀ of 5.7 nM and a D_max of 90%. QXG-6442 induces antiproliferative effects in MOLM-14 cell line ^[1].

HY-148112

Casein kinase 1δ-IN-1	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-1 is an inhibitor of casein kinase 1δ (CK1δ). Casein kinase 1δ-IN-1 can be used for the research of neurodegenerative diseases such as tauopathies ^[1].

HY-15424R

5-Iodotubercidin (Standard) NSC 113939 (Standard); 5-ITu (Standard)	Adenosine Kinase Reference Standards	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin ^[1] .

HY-160532

CK1α degrader-1 1 Publications Verification	Casein Kinase	Cancer
CK1α degrader-1 (Compound 82) is an orally active *CK1α* degrader with a DC₅₀ of 0.105 μM. CK1α degrader-1 can be used for the research of cancer ^[1].

HY-108907

SR-1277	Casein Kinase	Cancer
SR-1277 is a potent, selective and ATP competitive *CK1δ/ε* inhibitor, with IC₅₀s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC₅₀s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer ^[1].

HY-159646A

(R,R)-BMS-986397	Casein Kinase	Cancer
(R,R)-BMS-986397 is a *CK1α* degrader (DC₅₀ between 0.1-0.5 pM). (R,R)-BMS-986397 can be used in anti-leukemia research ^[1].

HY-103383

(R)-DRF053 dihydrochloride	CDK Casein Kinase	Neurological Disease Cancer
(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC₅₀s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model ^[1].

HY-178335

*SGC-CK1γ-1*	LDLR Wnt CMV	Infection
SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus (CMV) replication. SGC-CK1γ-1 can be used for the research of infection ^[1].

HY-P11119

CKS peptide	Casein Kinase	Neurological Disease
CKS peptide is a selective substrate peptide for *CK1. CKS peptide can used to measure CK1* activity ^[1].

HY-153866A

CK1-IN-2 hydrochloride	Casein Kinase	Cancer
CK1-IN-2 (compound Nr.4) hydrochloride is a potent *CK1* inhibitor with an IC₅₀ values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively ^[1].

HY-12470A

PF-4800567 hydrochloride	Casein Kinase	Cancer
PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC₅₀?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways ^[1].

HY-162756

CK1-IN-4	Casein Kinase	Neurological Disease
CK1-IN-4 (Compound 59) is an inhibitor for casein kinase *CK1δ* with IC₅₀ of 2.74 μM. CK1-IN-4 exhibits neuroprotective effect in Ethacrynic acid (HY-B1640)-treated SH-SY5Y cells ^[1].

Cat. No.	Product Name	Type

HY-12879G

IWP-4

Fluorescent Dye

IWP-4 (GMP) is the GMP-grade form of IWP-4 (HY-12879). IWP-4 is a Wnt inhibitor with an IC₅₀ of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC₅₀ of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC₅₀ = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure ^[1] .

Cat. No.	Product Name	Type

HY-12879G

IWP-4

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P11119

CKS peptide	Casein Kinase	Neurological Disease
CKS peptide is a selective substrate peptide for *CK1. CKS peptide can used to measure CK1* activity ^[1].

HY-P5526

CCK1-specific peptide substrate	Casein Kinase	Others
CCK1-specific peptide substrate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)

HY-P10606

CK1tide	Biochemical Assay Reagents	Others
CK1tide is a substrate for casein kinase 1 (CK1) and can be used to assess CK1's in vitro catalytic activity by detecting whether CK1 can phosphorylate it ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3127

Orobol	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Isoflavones Source Classification	Casein Kinase PI3K VEGFR
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits *CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45* μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) ^[1] .

HY-121944

Ricinine	Alkaloids Classification of Application Fields Ricinus communis L. Other Diseases Pyridine Alkaloids Euphorbiaceae Plants Disease Research Fields Source Classification	Casein Kinase Wnt
Ricinine exhibits hepatoprotection in CCl4-induced liver damage. Ricinine is also a *CK1α* inhibitor, and may activate Wnt pathway ^[1] .

HY-N6841

Rhodiolin 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Glucose-6-Phosphate Isomerase (GPI) Casein Kinase Virus Protease Flavivirus PI3K Akt mTOR Apoptosis
Rhodiolin, a flavonoid, is an orally active glucose 6-phosphate isomerase (GPI) inhibitor. Rhodiolin inhibits papillary thyroid cancer (PTC) by targeting glycolysis enzyme glucose 6-phosphate isomerase GPI and suppressing PI3K/AKT/mTOR phosphorylation and induce apoptosis. Rhodiolin as a NS2B-NS3 protease inhibitor can disrupt dengue viral replication. Rhodiolin is also a potential candidate for developing anticancer strategies inhibiting *CK1ε* kinase. Rhodiolin can be used for the study of anti-tumor and anti-viral ^[1] .

HY-N7183

9-Hydroxycanthin-6-one	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Plants Source Classification	NF-κB GSK-3 β-catenin Wnt
9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer ^[1] .

Recombinant Proteins Recommended:

Species:	Human (14)
Tag:	His (7) Strep (1) Tag Free (3) GST (4)
Source:	sf9 insect cells (3) Sf9 insect cells (7) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702668

	CSNK1A1/Casein Kinase I alpha Protein, Human (Active, sf9, His, Strep) CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; ck1; ck1a; ck1alpha; ckIa; ckIalpha; clock regulator kinase; ckI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975	Human	Sf9 insect cells
	Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1/Casein Kinase I alpha Protein, Human (sf9, His, Strep) is the recombinant human-derived CSNK1A1, expressed by Sf9 insect cells, with Strep, His labeled tag.

HY-P72872

	CSNK1A1/Casein Kinase I alpha Protein, Human (Active, sf9, GST) Casein kinase I isoform alpha; ckI-alpha; ck1; CSNK1A1	Human	Sf9 insect cells
	Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1/Casein Kinase I alpha Protein, Human (sf9, GST) is the recombinant human-derived Casein Kinase I alpha protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P72152

	CSNK1E Protein, Human (Inactive, His) Casein kinase 1 epsilon; Casein kinase I; Casein kinase I epsilon; Casein kinase I isoform epsilon; ckI epsilon; ckI-epsilon; ckIe; ckIepsilon; CSNK 1E; CSNK1E; DBT; Doubletime, Drosophila, homolog of; EC 2.7.11.1; epsilon isoform; Hck IE; KC1E; KC1E_HUMAN; kinase ck1 epsilon; MGC 10398	Human	E. coli
	CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (His) is the recombinant human-derived CSNK1E protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705796

	CSNK1E Protein, Human (Active, sf9) Casein kinase 1 epsilon; Casein kinase I; Casein kinase I epsilon; Casein kinase I isoform epsilon; ckI epsilon; ckI-epsilon; ckIe; ckIepsilon; CSNK 1E; CSNK1E; DBT; Doubletime, Drosophila, homolog of; EC 2.7.11.1; epsilon isoform; Hck IE; KC1E; KC1E_HUMAN; kinase ck1 epsilon; MGC 10398	Human	sf9 insect cells

HY-P705484

	CK1d Protein, Human (His) CSNK1D; Casein kinase I isoform delta; ckI-delta; ckId; Tau-protein kinase CSNK1D	Human	E. coli

HY-P72759

	MIP-4/CCL18 Protein, Human (His) C-C motif chemokine 18; AMAC-1; DC-ck1; MIP-4; CCL18; PARC; SCYA18	Human	E. coli
	MIP-4/CCL18 Protein, Human (His) is a CC chemokine ligand that binds to PITPNM3, GPR30 and CCR8 receptors and also acts as a neutral CCR3 antagonist mediating inflammation, autoimmunity and carcinogenesis. MIP-4/CCL18 Protein, Human (His) is a recombinant human MIP-4/CCL18 (A21-A89) protein expressed by E. coli with a his tag at N end.

HY-P701659

	CK1γ3 Protein, Human (Active, sf9) CSNK1G3; Casein kinase I isoform gamma-3; ckI-gamma 3	Human	Sf9 insect cells
	The CK1γ3 protein is a serine/threonine protein kinase in the casein kinase family that prefers acidic proteins, including casein. It has broad substrate specificity and can phosphorylate a variety of proteins, affecting diverse cellular processes. CK1γ3 Protein, Human (sf9) is the recombinant human-derived CK1γ3 protein, expressed by sf9 insect cells , with tag free.

HY-P701658

	CK1d Protein, Human (Active, sf9, GST) CSNK1D; Casein kinase I isoform delta; ckI-delta; ckId; Tau-protein kinase CSNK1D	Human	Sf9 insect cells
	The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d Protein, Human (sf9, GST) is the recombinant human-derived CK1d protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701660

	CK1γ3 Protein, Human (Active, sf9, GST) CSNK1G3; Casein kinase I isoform gamma-3; ckI-gamma 3	Human	Sf9 insect cells
	The CK1γ3 protein is a serine/threonine protein kinase in the casein kinase family that prefers acidic proteins, including casein. It has broad substrate specificity and can phosphorylate a variety of proteins, affecting diverse cellular processes. CK1γ3 Protein, Human (sf9, GST) is the recombinant human-derived CK1γ3 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702667

	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (Active, sf9, GST) CSNK1G2; casein kinase 1 gamma 2; ck1g2	Human	Sf9 insect cells
	Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. Casein Kinase I gamma-2/CSNK1G2 Protein, Human (sf9, GST) is the recombinant human-derived CSNK1G2, expressed by Sf9 insect cells, with GST labeled tag.

HY-P705797

	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (350a.a, sf9) CSNK1G2; casein kinase 1 gamma 2; ck1g2	Human	sf9 insect cells

HY-P7741

	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (His) rHuCasein kinase I isoform gamma-2, His; Casein kinase I isoform gamma-2; ck1G2; CSNK1G2	Human	E. coli
	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family.

HY-P705798

	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (350a.a, sf9, His) CSNK1G2; casein kinase 1 gamma 2; ck1g2	Human	sf9 insect cells

HY-P72873

	Casein Kinase I gamma-2/CSNK1G2 Protein, Human (Active, sf9, His) Casein kinase I isoform gamma-2; ckI-gamma 2; CSNK1G2; ck1G2	Human	Sf9 insect cells
	Casein kinase I gamma-2 is a serine/threonine protein kinase that targets acidic proteins and phosphorylates a variety of substrates, such as COL4A3BP/CERT, MTA1 and SMAD3, especially destabilizing SMAD3 and inhibiting TGF- beta reaction. Hyperphosphorylation of COL4A3BP/CERT disrupts ER-to-Golgi transport and affects the synthesis of ceramide and sphingomyelin. Casein Kinase I gamma-2/CSNK1G2 Protein, Human (sf9, His) is the recombinant human-derived Casein Kinase I gamma-2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (6) Mouse (3) Rat (5)
Application:	IHC-P (3) ICC/IF (1) IP (2) WB (4) ELISA (1)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85075

	Casein Kinase 1 alpha Antibody (YA4767) CSNK1A1; Casein kinase I isoform alpha; ckI-alpha; ck1	WB, IHC-P, ICC/IF, ELISA	Human
	Casein Kinase 1 alpha Antibody (YA4767) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Casein Kinase 1 alpha.

HY-P80585

	Casein Kinase 1 alpha Antibody (YA564) CSNK1A1; Casein kinase I isoform alpha; ckI-alpha; ck1	WB, IP	Human, Rat
	Casein Kinase 1 alpha Antibody (YA564) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 1 alpha.

HY-P80585A

	Casein Kinase 1 alpha Antibody (YA564)(PBS only) CSNK1A1; Casein kinase I isoform alpha; ckI-alpha; ck1	WB, IP	Human, Rat
	Casein Kinase 1 alpha Antibody (YA564) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Casein Kinase 1 alpha.

HY-P82920

	Cytokeratin 1 Antibody (YA2665) 67 kDa cytokeratin; ck1; EHK; Epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; Keratin; KRT 1; KRT1A; NEPPK; type II cytoskeletal 1; Type-II keratin Kb1	WB	Human, Mouse, Rat
	Cytokeratin 1 Antibody (YA2665) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 1.

HY-P88398

	CSNK1G1 Antibody (YA8082) ck1gamma1	IHC-P	Human, Mouse, Rat
	CSNK1G1 Antibody (YA8082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CSNK1G1.

HY-P88398A

	CSNK1G1 Antibody (YA8082)(PBS only) ck1gamma1	IHC-P	Human, Mouse, Rat
	CSNK1G1 Antibody (YA8082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CSNK1G1.

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Targets Recommended: Creatine Kinase Choline Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12879G

IWP-4	Wnt Casein Kinase	Cardiovascular Disease Neurological Disease Cancer
IWP-4 (GMP) is the GMP-grade form of IWP-4 (HY-12879). IWP-4 is a Wnt inhibitor with an IC₅₀ of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC₅₀ of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC₅₀ = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure ^[1] .

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