Casein Kinase I gamma-2/CSNK1G2 Protein, Human (His)
Casein Kinase I gamma-2/CSNK1G2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
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Biological Activity
Description
Casein Kinase I gamma-2/CSNK1G2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family[1].
Background
Casein kinase I gamma 2 isoform (CSNK1G2) is a member of the casein kinase I (CKI) subfamily. The casein kinase I (CKI) family of serine/threonine kinases is ubiquitously expressed in a wide range of eukaryotes, including yeast and humans as well as in plants.This kinase family also includes other isoforms (alpha, beta, gamma, and delta). both CKI isoforms except for gamma isoform, can increase the phosphorylation of Dsh in vivo.CSNK1G2 is overexpressed in human cancers, it may act as an oncoprotein during tumorigenesis. CSNK1G2 can acts as an oncoprotein during tumorigenesis. In addition, we found that CKI-γ2 can phosphorylate MTA1s, but not ER, in an anti-estrogendependent manner
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
P78368 (M18-K415)
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Molecular Construction
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N-term
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6*His
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CSNK1G2 (M18-K415)
Accession # P78368 -
C-term
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Protein Length
Partial
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Synonyms
CSNK1G2; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase 1 Gamma 2; Casein Kinase 1, Gamma 2; CK1g2; Casein Kinase I; Casein Kinase I Isoform Gamma-2; CK1G2; CKI-Gamma 2
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AA Sequence
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
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Predicted Molecular Mass
47.6 kDa
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Molecular Weight
Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
References
[1]. R M McKay, et al. The casein kinase I family in Wnt signaling. Dev Biol. 2001 Jul 15;235(2):388-96. [Content Brief]
[2]. Sandip K Mishra, et al. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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