Casein Kinase I gamma-2 Protein, Human (His)

Casein kinase I gamma-2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family^[1].

Casein kinase I gamma 2 isoform (CSNK1G2) is a member of the casein kinase I (CKI) subfamily. The casein kinase I (CKI) family of serine/threonine kinases is ubiquitously expressed in a wide range of eukaryotes, including yeast and humans as well as in plants.
This kinase family also includes other isoforms (alpha, beta, gamma, and delta). both CKI isoforms except for gamma isoform, can increase the phosphorylation of Dsh in vivo.
CSNK1G2 is overexpressed in human cancers, it may act as an oncoprotein during tumorigenesis. CSNK1G2 can acts as an oncoprotein during tumorigenesis. In addition, we found that CKI-γ2 can phosphorylate MTA1s, but not ER, in an anti-estrogendependent manner

Human

E. coli

N-6*His

P78368 (F92-K415)

1455  [NCBI]

HHHHHHMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK

Approximately 55.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. R M McKay, et al. The casein kinase I family in Wnt signaling. Dev Biol. 2001 Jul 15;235(2):388-96.  [Content Brief]

  [2]. Sandip K Mishra, et al. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9.  [Content Brief]