CSNK1G2 - casein kinase 1 gamma 2 Gene

Also Known as CK1g2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1455

About CSNK1G2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,941,172-1,981,338 (from NCBI)

This gene has 11 transcripts (splice variants), 333 orthologues and 12 paralogues. Broad expression in testis (RPKM 21.2), spleen (RPKM 15.0) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

CSNK1G2 Products (1)

mRNA Protein Name
NM_001319.7 NP_001310.3 casein kinase I isoform gamma-2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15917222 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
25500533 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1G2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (46 - 281)

CK1gamma_C

CK1gamma_C: Casein kinase 1 gamma C terminal (357 - 385)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

casein kinase I isoform gamma-2

casein kinase I

  • CKI-gamma 2

CSNK1G2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4-2
Y2H Prey Pooling
32296183
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4-2
Validated Y2H
32296183
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4-2
Y2H Array
32296183
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4-2
Anti Tag CoIP
28514442
Intra
CSNK1G2 P78368 CSNK1G1 Homo sapiens Q9HCP0
Pull Down
32707033
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4
Pull Down
32707033
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4
Anti Tag CoIP
33961781
Intra
CSNK1G2 P78368 CERT1 Homo sapiens Q9Y5P4
Y2H Pooling
16189514
Intra
CSNK1G2 P78368 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
CSNK1G2 P78368 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
CSNK1G2 P78368 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSNK1G2 Proteins

Cat. No. Product Name Accession Purity
HY-P7741 Casein Kinase I gamma-2/CSNK1G2 Protein, Human (His) P78368 (M18-K415) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72873 Casein Kinase I gamma-2/CSNK1G2 Protein, Human (Active, sf9, His) P78368 (M18-K415) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lissencephaly 8

  • LIS8
Familial Febrile Seizures

  • Familial Febrile Convulsions

  • Feb

  • Febrile Seizures, Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-184652 LRRK2/JNK3-IN-1 Inhibitor / Unkown
HY-RS03249 CSNK1G2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20628 Csnk1g2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27137 Csnk1g2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CSNK1G2 VGNC VGNC:39668
Mus musculus CSNK1G2 MGD MGI:1920014
Bos taurus CSNK1G2 VGNC VGNC:27767
Macaca mulatta CSNK1G2 VGNC VGNC:103802
Felis catus CSNK1G2 VGNC VGNC:78432
Rattus norvegicus CSNK1G2 RGD RGD:621407
Others CSNK1G2 NCBI