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Cat. No.: HY-181048

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CK1α-IN-1

CK1α-IN-1 (Compound 7a) is a selective CK1α inhibitor with an IC₅₀ of 10.96 nM. CK1α-IN-1 dose-dependently stabilizes p53 protein. CK1α-IN-1 has anticancer activity against acute monocytic leukemia.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₇N₇
Molecular Weight:365.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CK1α-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

CK1α

10.96 nM (IC₅₀)

All Casein Kinase Isoforms :

Chemical Information

Molecular Weight 365.48
Formula C₂₀H₂₇N₇
SMILES

N[C@H]1CC[C@H](NC2=NC(C3=C(CC4CC4)N(C)N=C3)=C5C(NC=C5)=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu M, et al. Design, Synthesis, and Structure–Activity Relationship Studies of 7 H-Pyrrolo [2, 3-d] pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) Inhibitors[J]. ACS Medicinal Chemistry Letters, 2026.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CK1α-IN-1

All Casein Kinase Isoforms