1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
    MAPK/ERK Pathway
  2. Casein Kinase
    ERK
    CDK
  3. Longdaysin

Longdaysin 

Cat. No.: HY-18285 Purity: 99.92%
Handling Instructions

Longdaysin is a CK1α, CK1δ, CDK7, and ERK2 inhibitor with IC50s of  5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively.

For research use only. We do not sell to patients.

Longdaysin Chemical Structure

Longdaysin Chemical Structure

CAS No. : 1353867-91-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 690 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Longdaysin is a CK1α, CK1δ, CDK7, and ERK2 inhibitor with IC50s of  5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively[1][2].

IC50 & Target[2]

CKIα

5.6 μM (IC50)

CKIδ

8.8 μM (IC50)

CDK7

29 μM (IC50)

ERK2

52 μM (IC50)

Molecular Weight

335.33

Formula

C₁₆H₁₆F₃N₅

CAS No.

1353867-91-0

SMILES

FC(F)(F)C1=CC=CC(CNC2=NC=NC3=C2N=CN3C(C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (372.77 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9821 mL 14.9107 mL 29.8214 mL
5 mM 0.5964 mL 2.9821 mL 5.9643 mL
10 mM 0.2982 mL 1.4911 mL 2.9821 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Longdaysin
Cat. No.:
HY-18285
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