1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. SR-1277

SR-1277 

Cat. No.: HY-108907
Handling Instructions

SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer.

For research use only. We do not sell to patients.

SR-1277 Chemical Structure

SR-1277 Chemical Structure

CAS No. : 1446715-47-4

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Description

SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].

IC50 & Target[1]

CKIδ

49 nM (IC50)

CKIϵ

260 nM (IC50)

In Vitro

SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM•h), T1/2 (1.42 h) and brain penetration (24%) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

477.50

Formula

C₂₁H₁₉N₉O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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