2. Cell Cycle/DNA Damage Stem Cell/Wnt MAPK/ERK Pathway Epigenetics TGF-beta/Smad
  3. Checkpoint Kinase (Chk) Casein Kinase MEK PKC
  4. (E/Z)-Chk2-IN-1

(E/Z)-Chk2-IN-1  (Synonyms: (E/Z)-Hymenialdisine analogue-1)

Cat. No.: HY-112477A
Handling Instructions Technical Support

(E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC50 values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

(E/Z)-Chk2-IN-1

(E/Z)-Chk2-IN-1 Chemical Structure

CAS No. : 693222-51-4

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Other Forms of (E/Z)-Chk2-IN-1:

(E/Z)-Chk2-IN-1 Related Antibodies

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Chk1 Chk2 BUBR1

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CK1 CK2

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4 MAP2K7/MEK7

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

(E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC50 values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer[1].

IC50 & Target[1]

Chk2

8 nM (IC50)

CK1δ

 

MEK1

 

PKCα

 

PKC-βII

 

Molecular Weight

295.30

Formula

C15H13N5O2
CAS No.
SMILES

O=C1N=C(N/C1=C2C3=C(C(NCC\2)=O)NC4=C3C=CC=C4)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(E/Z)-Chk2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Chk2-IN-1693222-51-4(E/Z)-Hymenialdisine analogue-1Checkpoint Kinase (Chk)Casein KinaseMEKPKCMitogen-activated protein kinase kinaseMAPKKMAP2KProtein kinase CInhibitorinhibitorinhibit

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