(E/Z)-Chk2-IN-1
(E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC50 values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 693222-51-4
- Formula: C15H13N5O2
- Molecular Weight:295.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Chk2 8 nM (IC50) |
CK1δ |
MEK1 |
PKCα |
PKC-βII |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
3.5 μM
Compound: 64
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Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay
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[PMID: 36496202] |
Chemical Information
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CAS No. 693222-51-4
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Molecular Weight 295.30
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Formula C15H13N5O2
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SMILES
O=C1N=C(N/C1=C2C3=C(C(NCC\2)=O)NC4=C3C=CC=C4)N
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Synonyms
(E/Z)-Hymenialdisine analogue-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E/Z)-Chk2-IN-1 Related Classifications
HY-112477A Related Classifications
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