693222-51-4
Chemical Structure
(E/Z)-Chk2-IN-1
Synonym(s): (E/Z)-Hymenialdisine analogue-1
- CAS No.: 693222-51-4
- Formula:C15H13N5O2
- Molecular Weight:295.30
IUPAC Name: (Z)-5-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one
InChIKey: SMPPSGXPGZSJCP-FLIBITNWSA-N
SMILES: O=C1N=C(N/C1=C2C3=C(C(NCC\2)=O)NC4=C3C=CC=C4)N
Biological Activity: (E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC50 values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(E/Z)-Chk2-IN-1 | (E/Z)-Chk2-IN-1 ((E/Z)-Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z)-Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βⅡ) with IC50 values both >89 nM. (E/Z)-Chk2-IN-1 can be used for the research of cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
