CK1γ-IN-1
CK1γ-IN-1 is a non-selective CK1 kinase inhibitor with IC50 values of 780 nM, 570 nM and 990 nM against human CK1γ1, CK1γ2, CK1γ3, respectively. The non-specific binding of CK1γ-IN-1 to multiple kinases enables its application in biological studies of specific CK1γ.
For research use only. We do not sell to patients.
- CAS No.: 1397706-29-4
- Formula: C17H16N4O
- Molecular Weight:292.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CK1γ1 780 nM (IC50) |
CK1γ2 570 nM (IC50) |
CK1γ3 990 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.7 μM
Compound: 1h
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Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting
Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting
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[PMID: 22877629] |
CK1γ-IN-1 (compound 1h) (0-10 μM; 2 h) potently binds to and stabilizes all three subtypes, namely CK1γ1, CK1γ2, and CK1γ3, in living HEK293 cells, with corresponding IC50 values of 780 nM, 570 nM, and 990 nM, respectively[1].
CK1γ-IN-1 potently inhibits the enzymatic activities of CK1γ1 (IC50=128 nM) and CK1γ2 (IC50=28 nM) in cell-free radiometric assays, while exerts weak inhibitory effect on the activity of CK1γ3 (IC50=1661 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1397706-29-4
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Molecular Weight 292.34
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Formula C17H16N4O
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SMILES
OC(C)(C)C(C=C1)=CC=C1NC2=NC3=CC=C(C#N)C=C3N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CK1γ-IN-1 Related Classifications
HY-181586 Related Classifications
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