CK1γ-IN-1 

CK1γ-IN-1 is a non-selective CK1 kinase inhibitor with IC₅₀ values of 780 nM, 570 nM and 990 nM against human CK1γ1, CK1γ2, CK1γ3, respectively. The non-specific binding of CK1γ-IN-1 to multiple kinases enables its application in biological studies of specific CK1γ^[1].

CK1γ-IN-1 (compound 1h) (0-10 μM; 2 h) potently binds to and stabilizes all three subtypes, namely CK1γ1, CK1γ2, and CK1γ3, in living HEK293 cells, with corresponding IC₅₀ values of 780 nM, 570 nM, and 990 nM, respectively^[1].
CK1γ-IN-1 potently inhibits the enzymatic activities of CK1γ1 (IC₅₀=128 nM) and CK1γ2 (IC₅₀=28 nM) in cell-free radiometric assays, while exerts weak inhibitory effect on the activity of CK1γ3 (IC₅₀=1661 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

292.34

C₁₇H₁₆N₄O

1397706-29-4

OC(C)(C)C(C=C1)=CC=C1NC2=NC3=CC=C(C#N)C=C3N2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Capener JL, et al. Development of a Chemical Probe to Enable Characterization of the Casein Kinase 1γ Subfamily. J Med Chem. 2026 Feb 12;69(3):2666-2684.  [Content Brief]