QXG-6442
Based on 1 Customer Validation
QXG-6442 is a CK1α Molecular Glue Degrader. QXG-6442 exhibits CK1α degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. QXG-6442 induces antiproliferative effects in MOLM-14 cell line.
For research use only. We do not sell to patients.
- Purity: 99.52%
- CAS No.: 3099928-67-0
- Formula: C21H17N5O4
- Molecular Weight:403.39
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Stem Cell Signaling Compound Library
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Wnt/Hedgehog/Notch Compound Library
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
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Cancer Stem Cells Compound Library
HY-L135
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Molecular Glue Compound Library
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Highly Selective Inhibitors Library
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Serine/Threonine Kinase Inhibitor Library
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Biological Activity
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CK1α 5.7 nM (DC50) |
Chemical Information
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CAS No. 3099928-67-0
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Appearance Solid
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Molecular Weight 403.39
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Formula C21H17N5O4
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Color White to off-white
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SMILES
O=C(C1=CN2C=CC=CC2=N1)NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (247.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4790 mL | 12.3950 mL | 24.7899 mL | 61.9748 mL |
| 5 mM | 0.4958 mL | 2.4790 mL | 4.9580 mL | 12.3950 mL | |
| 10 mM | 0.2479 mL | 1.2395 mL | 2.4790 mL | 6.1975 mL | |
| 15 mM | 0.1653 mL | 0.8263 mL | 1.6527 mL | 4.1317 mL | |
| 20 mM | 0.1239 mL | 0.6197 mL | 1.2395 mL | 3.0987 mL | |
| 25 mM | 0.0992 mL | 0.4958 mL | 0.9916 mL | 2.4790 mL | |
| 30 mM | 0.0826 mL | 0.4132 mL | 0.8263 mL | 2.0658 mL | |
| 40 mM | 0.0620 mL | 0.3099 mL | 0.6197 mL | 1.5494 mL | |
| 50 mM | 0.0496 mL | 0.2479 mL | 0.4958 mL | 1.2395 mL | |
| 60 mM | 0.0413 mL | 0.2066 mL | 0.4132 mL | 1.0329 mL | |
| 80 mM | 0.0310 mL | 0.1549 mL | 0.3099 mL | 0.7747 mL | |
| 100 mM | 0.0248 mL | 0.1239 mL | 0.2479 mL | 0.6197 mL |
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