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DPPH free radical scavenging activity

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By Targets:	Adenosine Receptor (1) Akt (3) Aldose Reductase (1) Amylases (2) AP-1 (2) Apoptosis (3) Bacterial (9) Bcl-2 Family (1) Biochemical Assay Reagents (2) Caspase (1) Cholinesterase (ChE) (2) COX (5) Drug Derivative (5) EGFR (1) Elastase (1) Endogenous Metabolite (5) Environmental Pollutants (1) Fungal (5) HDAC (1) HIV (2) HIV Integrase (1) HIV Protease (1) IFNAR (2) Influenza Virus (1) Interleukin Related (5) JNK (2) Keap1-Nrf2 (1) LDLR (1) Lipoxygenase (1) Microphthalmia Associated Transcription Factor (MITF) (1) Mitochondrial Metabolism (1) MMP (1) Monoamine Oxidase (1) NO Synthase (6) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) Parasite (1) PD-1/PD-L1 (2) PERK (2) Phosphodiesterase (PDE) (1) PI3K (1) PKA (1) Raf (1) Ras (2) Reactive Oxygen Species (ROS) (21) Reference Standards (7) SOD (1) STAT (2) Tim3 (2) TNF Receptor (1) TRP Channel (1) Tyrosinase (5) Wnt (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (12) Inflammation/Immunology (32) Metabolic Disease (14) Neurological Disease (10)
Click Chemistry:	Azide (1)

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112053

DPPH Maximum Cited Publications 46 Publications Verification 2,2-Diphenyl-1-picrylhydrazyl	Reactive Oxygen Species (ROS)	Metabolic Disease
DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .

HY-P1934A

Cyclo(L-Phe-L-Pro)	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-N1417

Sesamol 2 Publications Verification	Apoptosis	Cancer
Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC₅₀=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .

HY-N1312

Sinapaldehyde	COX Bacterial Reactive Oxygen Species (ROS) Interleukin Related NO Synthase PERK JNK	Infection Inflammation/Immunology
Sinapaldehyde is a methoxyphenol and a selective COX-2 inhibitor (IC₅₀: 47.8 µM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge *DPPH* free radicals (IC₅₀: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria .

HY-N0627

Kaempferol-7-O-β-D-glucopyranoside	LDLR	Others
Kaempferol-7-O-β-D-glucopyranoside is a flavonoid glycoside. Kaempferol-7-O-β-D-glucopyranoside exists in the root bark of Cudrania tricuspidata. Kaempferol-7-O-β-D-glucopyranoside inhibits Cu ²⁺-induced lipid peroxidation of low-density lipoprotein. Kaempferol-7-O-β-D-glucopyranoside possesses antioxidant activity and scavenges DPPH free radicals .

HY-W019885A

Sodium tripolyphosphate (STPP), 98% Sodium triphosphate pentabasic, 98%	Environmental Pollutants Biochemical Assay Reagents	Others
Sodium tripolyphosphate (STPP), 98% is an inorganic, non-toxic polyphosphate crosslinker, inducer and enhancer. Sodium tripolyphosphate (STPP), 98% induces the formation of unique needle-like microcrystals in sodium alginate-chitosan composite films. Sodium tripolyphosphate (STPP), 98% enhances the *DPPH* free radical scavenging activity of sodium alginate-chitosan composite films .

HY-N2443

Tribuloside 1 Publications Verification	Phosphodiesterase (PDE) Bacterial PKA Tyrosinase TRP Channel Microphthalmia Associated Transcription Factor (MITF) Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Tribuloside is a flavonoid and PDE4 inhibitor (IC₅₀: 6 μM). Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging *DPPH* free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury .

HY-127170

3-Hydroxycoumarin	Lipoxygenase Tyrosinase	Metabolic Disease Inflammation/Immunology
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC₅₀ for recombinant human tyrosinase (rHT) of 26 μM, and a K_i of 3.39 μM; its IC₅₀ for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC₅₀ = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos .

HY-N2907

Atranorin	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT	Infection Neurological Disease Inflammation/Immunology Cancer
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging *DPPH* and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-112053R

DPPH (Standard) 2,2-Diphenyl-1-picrylhydrazyl (Standard)	Reactive Oxygen Species (ROS) Reference Standards	Metabolic Disease
DPPH (Standard) is the analytical standard of DPPH. This product is intended for research and analytical applications. DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .

HY-124496

Piperitenone	Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Others
Piperitenone is a terpenoid, and exhibits antioxidant activity. Piperitenone scavenges DPPH free radicals with an IC₅₀ of 22.7 μg/mL, and inhibits the peroxidation of linoleic acid .

HY-131803

3'-Azido-3'-deoxyguanosine	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model . 3'-Azido-3'-deoxyguanosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-168993

BRCA2-IN-2	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
BRCA2-IN-2 (Compound 3i) has a strong binding affinity to the BRCA2 protein. BRCA2-IN-2 can inhibit the proliferation of breast cancer cells and scavenge *DPPH* free radicals. BRCA2-IN-2 has anti-tumor and antioxidant activities .

HY-W747297

β-Selinene	COX Endogenous Metabolite	Neurological Disease Inflammation/Immunology
β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus (Callicarpa macrophylla). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals (DPPH, NO, •OH) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase (COX) activity, reduce prostaglandin (such as PGE₂) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects .

HY-W002773

Methyl isovanillate	Endogenous Metabolite	Others
Methyl isovanillate is a secondary metabolite isolated from Vitex agnus-castus. Methyl isovanillate does not exhibit significant activity* in the DPPH free radical scavenging experiment* .

HY-W274194

Antioxidant agent-7	Reactive Oxygen Species (ROS)	Others
Antioxidant agent-7 (SD-7) is a benzodiazepine derivative with antioxidant activity with an IC₅₀ value of 470 nM to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical .

HY-N3421

Koaburaside	Interleukin Related TNF Receptor Influenza Virus	Infection Inflammation/Immunology Cancer
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-130294

Pyracrenic acid	Elastase	Inflammation/Immunology
Pyracrenic acid is an elastase inhibitor (IC₅₀ = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity .

HY-149313

α‑Amylase-IN-1	Amylases	Metabolic Disease
α Amylase-IN-1 (Compound 11) is an α-Amylase inhibitor with an IC₅₀ value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC₅₀ value of 53.49 μM for scavenging *DPPH* free radicals. IC₅₀ can be used in the study of diabetes and oxidative stress-related diseases.

HY-N1312R

Sinapaldehyde (Standard)	Reference Standards COX Bacterial Reactive Oxygen Species (ROS) Interleukin Related NO Synthase PERK JNK	Infection Inflammation/Immunology
Sinapaldehyde is a methoxyphenol and a selective COX-2 inhibitor (IC50: 47.8 µM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge DPPH free radicals (IC50: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria .

HY-W012092

Ethyl 3,4,5-trimethoxybenzoate	Tyrosinase Reactive Oxygen Species (ROS)	Metabolic Disease Inflammation/Immunology
Ethyl 3,4,5-trimethoxybenzoate is a melanogenesis inhibitor. Ethyl 3,4,5-trimethoxybenzoate does not directly target tyrosinase activity, but inhibits melanin synthesis in a dose-dependent manner by downregulating α-MSH (HY-P0252)-induced tyrosinase protein expression and scavenging ROS. Ethyl 3,4,5-trimethoxybenzoate scavenges *DPPH* free radicals. Ethyl 3,4,5-trimethoxybenzoate can be used in the research of hyperpigmentation .

HY-W104752

5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol	Bacterial Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC₅₀ of 17.47 μM using DPPH free radical-scavenging method .

HY-N2907R

Atranorin (Standard)	Wnt Reference Standards Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT	Infection Neurological Disease Inflammation/Immunology Cancer
Atranorin (Standard) is the analytical standard of Atranorin (HY-N2907). This product is intended for research and analytical applications. Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging *DPPH* and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-N16606

2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone	Drug Derivative NO Synthase	Inflammation/Immunology
2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone (Compound 8) is an Acetophenone (HY-Y0989) derivative found in Acronychia oligophlebia. 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone exhibits anti-inflammatory and antioxidant activities. 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone can inhibit LPS (HY-D1056)-induced NO production (IC₅₀ = 34.5 μM) and scavenge DPPH free radical (SC₅₀ = 0.15 mM). 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone can be used for the research of inflammation .

HY-W207699

MAO-B-IN-46	Monoamine Oxidase Amylases	Neurological Disease Metabolic Disease Inflammation/Immunology
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC₅₀: 26.8 nM), with weak activity against hMAO-A (IC₅₀: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC₅₀: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge *DPPH* and ABTS free radicals, with IC₅₀ values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance .

HY-175862

ALR2-IN-9	Aldose Reductase Reactive Oxygen Species (ROS) PI3K Akt SOD p38 MAPK Keap1-Nrf2	Metabolic Disease
ALR2-IN-9 is a potent ALR2 inhibitor (IC₅₀ = 21.8 nM) with excellent antioxidant activity (EC₅₀ for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO₄- and H₂O₂-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research .

HY-133183

Urolignoside	Biochemical Assay Reagents	Others
Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model .

HY-155346

Free radical scavenger 1	Bacterial	Others
Free radical scavenger 1 (compound 8) shows scavenging activity against the *DPPH* radical, with the IC₅₀ of 43.39 μg/ml .

HY-N8169

10-O-Trans-p-methoxycinnamoylcatalpol	Others	Others
10-O-Trans-p-methoxycinnamoylcatalpol has antioxidant activity with the IC₅₀ value of 0.37 μM/mL in DPPH free radical scavenging assay .

HY-N7518

Eulophiol	MMP	Inflammation/Immunology
Eulophiol shows the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with an EC₅₀ of 27.7μM. Antioxidant activity .

HY-W714006

Cochliodinol	Reactive Oxygen Species (ROS)	Metabolic Disease
Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC₅₀=3.06 μg/mL) .

HY-N1994

Swertianine	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Swertianine is a hydroxyexanthone that can be isolated from Swertia decussata. Swertianine has antioxidant activity by inhibiting lipid peroxidation, scavenging DPPH and superoxide free radicals. Swertianine also inhibits γ-ray induced DNA damage of pBR322 with protective effect .

HY-N10294

Epicoccone B	HIV	Infection Inflammation/Immunology
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N1417R

Sesamol (Standard)	Reference Standards Apoptosis	Cancer
Sesamol (Standard) is the analytical standard of Sesamol. This product is intended for research and analytical applications. Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .

HY-146172

Antioxidant agent-3	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS ⁺ scavenging activity with IC₅₀s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H₂O₂-treated HepG2 cells .

HY-N8012

Multinoside A	COX NO Synthase	Others
Multinoside A (compound 6) is an antioxidant with DPPH free radical scavenging activity (IC₅₀=54.3 μg/mL). Multinoside A can also downregulate COX-2 expression (IC₅₀=9.6 μg/mL) and inhibit NO production (IC₅₀=43.9 μg/mL) .

HY-176437

Tyrosinase-IN-42	Tyrosinase	Metabolic Disease
Tyrosinase-IN-42 (Compound 13t) is a tyrosinase inhibitor (IC₅₀: 1.363 µM). Tyrosinase-IN-42 exhibits anti-browning effects on fresh-cut apples. Tyrosinase-IN-42 has antioxidant activity by scavenging DPPH and ABTS free radicals (IC₅₀: 57.90 and 45.64 µM, respectively) .

HY-N15578

Actinidioionoside	Others	Others
Actinidioionoside (Compound 2) is a megastigmane glucoside compound found in Borago officinalis L. Actinidioionoside has DPPH free radical scavenging activity (IC₅₀: 41.3 μM). Actinidioionoside has no significant cytotoxicity against A549 human lung cancer cells (IC₅₀ > 100 μM). Actinidioionoside can be used in antioxidant studies .

HY-P1934AR

Cyclo(L-Phe-L-Pro) (Standard)	Reference Standards Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-N13142

Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside	Others	Inflammation/Immunology
Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside (compound 3) is a flavonoid with antioxidant activity, which can be isolated from Margaritopsis carrascoana. Luteolin 7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside has good DPPH free radical scavenging activity (IC50=0.188 mg/mL) .

HY-N15727

2,5-Dimethylchromone-7-O-β-D-glucopyranoside	Others	Inflammation/Immunology
2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC₅₀ value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .

HY-N15536

N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside	Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease
N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is a phenolic amide glycoside compound found in Suaeda japonica. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside exhibits antioxidant activity, capable of effectively scavenging DPPH free radicals and reducing the production of ROS induced by H₂O₂ in cells, thus protecting cells from oxidative stress damage. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is promising for research of cardiovascular diseases and neurodegenerative diseases .

HY-N9086A

(rac)-Poriol 5,7,4'-Trihydroxy-6-methylflavanone	NO Synthase COX Interleukin Related	Inflammation/Immunology
(rac)-Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC₅₀ of 0.18 µg/mL. (rac)-Poriol inhibits the LPS (HY-D1056)-induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac)-Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β .

HY-149517

EGFR/BRAFV600E-IN-2	EGFR Raf Caspase Bcl-2 Family Apoptosis	Inflammation/Immunology Cancer
EGFR/BRAFV600E-IN-2 (compound 3g) is a potential multi-target inhibitor of EGFR, BRAF ^V600E, and EGFR ^T790M, and an inducer of apoptosis. EGFR/BRAFV600E-IN-2 can activate caspase-3, 8, and Bax, and downregulate the anti-apoptotic protein Bcl2, inducing apoptosis. EGFR/BRAF V600E-IN-2 also has antioxidant activity and DPPH free radical scavenging potency .

HY-175851

A2AAR antagonist 5	Adenosine Receptor	Neurological Disease
A2AAR antagonist 5 is a selective A_2AAR antagonist. A2AAR antagonist 5 inhibits NECA-stimulated adenylyl cyclase activity in hA_2AAR-expressing CHO cells with an IC₅₀ value of 1863 nM. A2AAR antagonist 5 possesses strong free radical scavenging activity, with an EC₅₀ value of 22.21 μM in the DPPH assay. A2AAR antagonist 5 exerts notable neuroprotective effects in in vitro cerebral ischemia models. A2AAR antagonist 5 can be used for the study of cerebral ischemia .

HY-170561

AChE/BuChE-IN-6	Cholinesterase (ChE)	Neurological Disease
AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC₅₀ values of 1.24 and 1.85 μg/mL, respectively. AChE/BuChE-IN-6 also exhibits strong *DPPH* free radical scavenging activity (IC₅₀ = 3.15 μg/mL). In vivo toxicity studies indicate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical markers compared to the control group after long-term administration, and no abnormalities were observed in liver and kidney tissues. AChE/BuChE-IN-6 holds promise for research into Alzheimer's disease .

HY-W450115

USF 2550A	Reactive Oxygen Species (ROS)	Inflammation/Immunology
USF 2550A is a class of fungus-derived 2-pyran compound with *DPPH* free radical scavenging activity. USF 2550A binds to DPPH free radicals in organic solvents to form adducts, thereby achieving free radical scavenging; in acetate buffer, the formed adducts undergo degradation, and the degradation products can continuously scavenge free radicals. USF 2550A can be used in antioxidant-related research .

HY-N17504

N-Formylnornuciferin	Others	Others
N-Formylnornuciferin is an N-acylaporphine alkaloid isolated from the stems of Tinospora crispa. N-Formylnornuciferin exhibits no scavenging activity against *DPPH* free radicals .

HY-N16742

Hydrangeifolin I	Drug Derivative	Others
Hydrangeifolin I is a natural phenolic compound.

HY-N19669

27-Hydroxyisomangiferolic acid	Reactive Oxygen Species (ROS)	Others Metabolic Disease Inflammation/Immunology Cancer
27-Hydroxyisomangiferolic acid, a cycloartane-type triterpene found in Indonesian propolis from East Java, acts as a weak scavenger with low free radical scavenging activity against *DPPH* (HY-112053) radicals. can be used for research on inflammation, heart disease, diabetes and cancer .

Cat. No.	Product Name	Type

HY-W019885A

Sodium tripolyphosphate (STPP), 98% Sodium triphosphate pentabasic, 98%	Biochemical Assay Reagents
Sodium tripolyphosphate (STPP), 98% is an inorganic, non-toxic polyphosphate crosslinker, inducer and enhancer. Sodium tripolyphosphate (STPP), 98% induces the formation of unique needle-like microcrystals in sodium alginate-chitosan composite films. Sodium tripolyphosphate (STPP), 98% enhances the *DPPH* free radical scavenging activity of sodium alginate-chitosan composite films .

Cat. No.	Product Name	Target	Research Area

HY-P1934A

Cyclo(L-Phe-L-Pro)	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-P1934AR

Cyclo(L-Phe-L-Pro) (Standard)	Reference Standards Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

Cat. No.	Product Name		Classification

HY-131803

3'-Azido-3'-deoxyguanosine		Azide
Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model . 3'-Azido-3'-deoxyguanosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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DPPH free radical scavenging activity

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