2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Antioxidant agent-3

Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+ scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells.

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Antioxidant agent-3 Chemical Structure

Antioxidant agent-3 Chemical Structure

CAS No. : 2710376-48-8

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Antioxidant agent-3 Related Antibodies

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Description

Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+ scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells[1].

In Vitro

Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS +• scavenging with the values of IC50 is 26.58 μM and 30.31 μM respectively[1].
Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC50 > 100 μM) and GES (IC50 > 200 μM) cells[1].
Antioxidant agent-3 can enhance viability of H2O2-induced HepG2 cells[1].
Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells[1].
Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H2O2-treated HepG2 cells, and exhibits more stability in methanol solution[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antioxidant agent-3 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: WI-38 and GES cells line
Concentration: 200, 100, 50, 25 and 12.5 μM
Incubation Time: 48 h
Result: Showed less toxicity in hemolysis assay and weaker antiproliferative effects.

Cell Viability Assay[1]

Cell Line: H2O2-damaged WI-38 and HepG2 cells
Concentration: 50, 25 and 12.5 μM
Incubation Time: 1 h
Result: Increased cells viability of H2O2-indcued cells and protected the H2O2-indcued cells against injury.

Apoptosis Analysis[1]

Cell Line: H2O2-damaged HepG2 cells
Concentration: 50, 25 and 12.5 μM
Incubation Time: 1 h
Result: Protect the H2O2-injured HepG2 cells against apoptosis through antioxidant effect.
Molecular Weight

358.30

Formula

C18H14O8
CAS No.
SMILES

O=C(C(C1=O)=CC2=C(O1)C(O)=C(O)C=C2)OCCC3=CC=C(O)C(O)=C3
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Purity & Documentation
References
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Antioxidant agent-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antioxidant agent-32710376-48-8Antioxidant agent3Antioxidant agent 3Reactive Oxygen Speciesantioxidantfree radical scavengingDPPH radicals scavengingABTS scavenging activityROSsuperoxide dismutaseSODglutathioneGSHInhibitorinhibitorinhibit

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