Antioxidant agent-3
Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+ scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells.
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- CAS No.: 2710376-48-8
- Formula: C18H14O8
- Molecular Weight:358.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS + scavenging with the values of IC50 is 26.58 μM and 30.31 μM respectively[1].
Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC50 > 100 μM) and GES (IC50 > 200 μM) cells[1].
Antioxidant agent-3 can enhance viability of H2O2-induced HepG2 cells[1].
Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells[1].
Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H2O2-treated HepG2 cells, and exhibits more stability in methanol solution[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WI-38 and GES cells line
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Concentration:200, 100, 50, 25 and 12.5 μM
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Incubation Time:48 h
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Result:Showed less toxicity in hemolysis assay and weaker antiproliferative effects.
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Cell Line:H2O2-damaged WI-38 and HepG2 cells
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Concentration:50, 25 and 12.5 μM
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Incubation Time:1 h
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Result:Increased cells viability of H2O2-indcued cells and protected the H2O2-indcued cells against injury.
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Cell Line:H2O2-damaged HepG2 cells
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Concentration:50, 25 and 12.5 μM
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Incubation Time:1 h
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Result:Protect the H2O2-injured HepG2 cells against apoptosis through antioxidant effect.
Chemical Information
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CAS No. 2710376-48-8
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Molecular Weight 358.30
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Formula C18H14O8
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SMILES
O=C(C(C1=O)=CC2=C(O1)C(O)=C(O)C=C2)OCCC3=CC=C(O)C(O)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antioxidant agent-3 Related Classifications
HY-146172 Related Classifications
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