Monasfluore A
Monasfluore A is an azaphenanthrenone derivative with antioxidant activity. Monasfluore A inhibits LPS-induced nitric oxide production. Monasfluore A scavenges DPPH and superoxide anion free radicals. Monasfluore A exerts cellular antioxidant activity in oxidatively damaged colon adenocarcinoma cells. Monasfluore A shows no antiproliferative effect on human laryngeal cancer cells and colon adenocarcinoma cells.
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- CAS No.: 1004537-75-0
- 화학식: C21H24O5
- 분자량:356.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Monasfluore A (compound 5) (6.25-100 μg/mL; 3 days) exhibits no anti-proliferative activity against human laryngeal carcinoma (HEp-2) cells and human colon adenocarcinoma (WiDr) cells, with an IC50 > 100 μg/mL for both cell lines[1].
Monasfluore A (5-20 μg/mL; 24 h) significantly and dose-dependently inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced nitric oxide production in murine macrophage (RAW 264.7) cells with an IC50 of 12.8 μg/mL, while maintaining high cell viability[1].
Monasfluore A (0.02-0.10 mg/mL; 0.2-18 mg/mL; 0-5 mg/mL), purified from functional Qu, shows concentration-dependent in vitro antioxidant activity via DPPH scavenging, superoxide anion scavenging, and yolk lipoprotein peroxidation inhibition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human laryngeal carcinoma (HEp-2) cells, human colon adenocarcinoma (WiDr) cells
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Concentration:6.25, 12.5, 25, 50, 100 μg/mL
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Incubation Time:3 days
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Result:Exhibited no anti-proliferative effects on HEp-2 or WiDr cells, with an IC50 value greater than 100 μg/mL for both cell lines.
Chemical Information
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CAS No. 1004537-75-0
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분자량 356.41
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화학식 C21H24O5
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SMILES
C[C@]12[C@]([C@@H](C(O2)=O)C(CCCCC)=O)([H])C3=COC(/C=C/C)=CC3=CC1=O
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Structure Classification
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Initial Source
Monascus purpureus
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Hsu YW, et al. New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568. Molecules. 2010;15(11):7815-7824. Published 2010 Nov 3. [Content Brief]
[2]. Wu L, et al. Comparative Study on the Antioxidant Activity of Monascus Yellow Pigments From Two Different Types of Hongqu-Functional Qu and Coloring Qu. Front Microbiol. 2021 Aug 2;12:715295. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Monasfluore A Related Classifications
HY-N11737 Related Classifications
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- Monasfluore A
- 1004537-75-0
- Free Radical Scavengers
- Drug Derivative
- Caco-2 cells
- human colon adenocarcinoma (WiDr) cells
- murine macrophage (RAW 264.7) cells
- nitric oxide
- DPPH
- human laryngeal carcinoma (HEp-2) cells
- colon adenocarcinoma cells
- superoxide anion free radicals
- yolk lipoprotein peroxidation
- lipopolysaccharide
- Inhibitor
- inhibitor
- inhibit