New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568

  • Molecules. 2010 Nov 3;15(11):7815-24. doi: 10.3390/molecules15117815.
Ya-Wen Hsu  1 ,  Li-Chuan Hsu ,  Chao-Lin Chang ,  Yu-Han Liang ,  Yao-Haur Kuo ,  Tzu-Ming Pan
Affiliations
  • 1. Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan. [email protected]
PMID: 21060290 DOI: 10.3390/molecules15117815
Abstract

Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance (1H- NMR, 13C-NMR, COSY, HMQC, and HMBC) and Other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC(50) = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC(50) = 12.89~21.14 μg/mL).

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