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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
92 Results for "
HK
" in MedChemExpress (MCE) Product Catalog:
Products (92)
92 Results for "HK" in MCE Product Catalog:
36
36 Publications Verification
Synonyms: Bromopyruvic acid; 3-BrPA; Hexokinase II Inhibitor II, 3-BP
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Research Areas:
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .
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4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
3
3 Cited Publications
Cat. No.: HY-N4185
CAS No.: 61153-77-3
2
2 Cited Publications
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PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .
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2 Cited Publications
Cat. No.: HY-N6954
CAS No.: 76996-27-5
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1
1 Cited Publications
Cat. No.: HY-W011151
CAS No.: 6025-53-2
Category:
Plants Cytokinin Catharanthus roseus (L.) G. Don Agricultural Research Apocynaceae Alkaloids Other Alkaloids Other Diseases Phytohormone Disease Research Fields
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1
1 Cited Publications
Synonyms: Cycloartenol ferulate; Cycloartenol ferulic acid ester
1
1 Cited Publications
Cat. No.: HY-P71590
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KLK14; Kallikrein-Related Peptidase 14 Transcript Variant 2; Kallikrein Related Peptidase 14; Kallikrein-Related Peptidase 14 Transcript Variant 3; KLK-L6; Kallikrein 14; Kallikrein-Like Protein 6; KLKL6; Kallikrein-14; HK14
Synonyms: AZD0865
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Linaprazan (AZD0865) can inhibit H+,K+ -ATPase in the stomach through K+ competitive binding, (IC50: 1.0 ± 0.2 μM), it has a strong inhibitory effect on acid. Linaprazan (AZD0865) can be used for research on reflux esophagitis with oral activity .
Category:
Cardiovascular Disease Cercis chinensis Bunge Metabolic Disease Plants Compositae other families Flavonoids Flavonones Phenols Polyphenols Disease Research Fields
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Cat. No.: HY-175035
CAS No.: 3114833-48-3
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HK-2-IN-1 is a Hexokinase 2 (HK-2) inhibitor. HK-2-IN-1 exhibits a non-activating effect on human recombinant HK-2 enzyme. HK-2-IN-1 has anti-tumor activity, affecting immune cells in the tumor microenvironment. HK-2-IN-1 has immunomodulatory effects and is potentially useful in the study of cancers such as colon cancer, liver cancer, and breast cancer .
Cat. No.: HY-P2040
CAS No.: 118399-22-7
Cat. No.: HY-P4331
CAS No.: 113865-85-3
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Cat. No.: HY-168717
CAS No.: 3056278-80-6
Research Areas:
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle .
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p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4].
non-alcoholic fatty liver disease .
Cat. No.: HY-P990123
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SP4f is an activator ofPPAR-γ, with the EC50 of 826 nM in HK-2 cells. SP4f reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .
Cat. No.: HY-170799
CAS No.: 2127358-36-3
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Research Areas:
HNC-1664 is the orally active inhibitor for RNA-dependent RNA polymerase (RdRP). HNC-1664 exhibits broad-spectrum antiviral activity against coronavirus (SARS-CoV-2 wildtype and its mutants XBB.1.18, HK.3.1, BF.7.14, BA.1HCoV-229E, HCoV-OC43) and arenavirus. HNC-1664 exhibits anti-infectious activity in SARS-CoV-2 Delta infected mouse models .
Cat. No.: HY-117225
CAS No.: 127780-16-9
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Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor Pantoprazole (HY-17507) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
