KCNA5/KV1-5 Antibody (YA6623)

KCNA5/KV1-5 Antibody (YA6623) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KCNA5/KV1-5.

Predicted band size: 67 kDa;

P22460

3741 [NCBI]

Shipping with blue ice.

Function：Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets|Exhibits a faster depolarization rate, reduced voltage-dependent recovery from inactivation and an excessive cumulative inactivation

Subcellular Localization：Cell membrane

Expression：
Tissue_Specificity: Pancreatic islets and insulinoma

Isoforms & Post-Translational Modification：P22460 has two isomers: P22460-1: 67228 Da (predicted); P22460-2: 44427 Da (predicted).
Glycosylated丨Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3

Subunit：Homotetramer and heterotetramer of potassium channel proteins (PubMed:20018952)

ATFB7 antibody; cardiac potassium channel antibody; HCK1 antibody; HK2 antibody; HPCN1 antibody; insulinoma and islet potassium channel antibody; KCNA5 antibody; KCNA5_HUMAN antibody; KV1.5 antibody; PCN1 antibody; ATFB7 antibody; cardiac potassium channel antibody; HCK1 antibody; HK2 antibody; HPCN1 antibody; insulinoma and islet potassium channel antibody; KCNA5 antibody; KCNA5_HUMAN antibody; KV1.5 antibody; PCN1 antibody; potassium channel 1 antibody; Potassium channel, insulinoma and islet cell antibody; Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody; Potassium voltage gated channel subfamily A member 5 antibody; Potassium voltage-gated channel subfamily A member 5 antibody; Voltage-gated potassium channel HK2 antibody; voltage-gated potassium channel protein Kv1.5 antibody; Voltage-gated potassium channel subunit Kv1.5 antibody;