KCNA5 - potassium voltage-gated channel subfamily A member 5 Gene

Also Known as HK2; HCK1; PCN1; ATFB7; HPCN1; KV1.5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3741

About KCNA5

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:5,043,879-5,046,788 (from NCBI)

This gene has 1 transcript (splice variant), 170 orthologues, 31 paralogues and is associated with 2 phenotypes.

Summary

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related Potassium Channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the Potassium Channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of Insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

KCNA5 Products (1)

mRNA	Protein	Name
NM_002234.4	NP_002225.2	potassium voltage-gated channel subfamily A member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-actinin binding	IPI IPI: Inferred from physical interaction	10812072	GOA
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	1986382	GOA
enables delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	19343045	GOA
enables outward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	12970345	GOA
enables outward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	16236819	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10812072	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8953041	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	12970345	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	8505626	GOA
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	17267549	GOA
enables voltage-gated potassium channel activity involved in SA node cell action potential repolarization	IMP IMP: Inferred from mutant phenotype	19343045	GOA
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IMP IMP: Inferred from mutant phenotype	19343045	GOA
enables voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization	IMP IMP: Inferred from mutant phenotype	23264583	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	19343045	GOA
involved in membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	16236819	GOA
involved in membrane repolarization during SA node cell action potential	IMP IMP: Inferred from mutant phenotype	19343045	GOA
involved in membrane repolarization during atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	19343045	GOA
involved in membrane repolarization during bundle of His cell action potential	IMP IMP: Inferred from mutant phenotype	23264583	GOA
involved in potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	1986382	GOA
involved in potassium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	16236819	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	12130714	GOA
acts upstream of or within potassium ion transport	IDA IDA: Inferred from direct assay	8576199	GOA
involved in regulation of atrial cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	19343045	GOA
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	19343045	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	1986382	GOA
involved in regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	12021261	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	23264583	GOA
located in intercalated disc	IDA IDA: Inferred from direct assay	7615797	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	18218624	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7615797	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	20018952	GOA
part of potassium channel complex	IDA IDA: Inferred from direct assay	12130714	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	1986382	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNA5 Protein Structure

BTB_2

Ion_trans

0
100
200
300
400
500
613 a.a.

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily A member 5	cardiac potassium channel

KCNA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNA5	P22460	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	KCNA5	P22460	SCRIB	Homo sapiens	Q14160	Phage Display	24550280
Intra	KCNA5	P22460	ACTN2	Homo sapiens	P35609	Y2H	10812072
Intra	KCNA5	P22460	ACTN2	Homo sapiens	P35609	Anti Bait CoIP	10812072

Cross: Cross-species interaction Intra: Intraspecies interaction

KCNA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810895	Kv1.5 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86930	KCNA5/KV1-5 Antibody (YA6623)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Atrial Fibrillation, Familial, 7	ATFB7 Fibrillation, Atrial, Familial, Type 7
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Cardiomyopathy, Dilated, 1o	Dilated Cardiomyopathy 1o CMD1O Dilated Cardiomyopathy With Ventricular Tachycardia Cardiomyopathy, Dilated, With Ventricular Tachycardia Cardiomyopathy, Dilated 1o Cardiomyopathy, Dilated, Type 1o
Pulmonary Venoocclusive Disease	Pulmonary Veno-Occlusive Disease Obstructive Disease Of The Pulmonary Veins Pvod Isolated Pulmonary Venous Sclerosis Venous Form Of Primary Pulmonary Hypertension Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Isolated Elevated Serum Creatine Phosphokinase Levels	Elevated Serum Cpk Idiopathic Hyperckemia Isolated Hyperckemia Elevated Serum Creatine Phosphokinase H-Ck Idiopathic Persistent Elevation Of Serum Creatine Kinase
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07101	KCNA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNA5	VGNC	VGNC:42232
Macaca mulatta	KCNA5	VGNC	VGNC:73965
Bos taurus	KCNA5	VGNC	VGNC:30425
Mus musculus	KCNA5	MGD	MGI:96662
Rattus norvegicus	KCNA5	RGD	RGD:2953
Felis catus	KCNA5	VGNC	VGNC:84042
Others	KCNA5	NCBI