1. Membrane Transporter/Ion Channel
  2. Proton Pump

AZD0865 (Synonyms: Linaprazan)

Cat. No.: HY-100412 Purity: 98.51%
Handling Instructions

AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding.

For research use only. We do not sell to patients.

AZD0865 Chemical Structure

AZD0865 Chemical Structure

CAS No. : 248919-64-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 339 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

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  • References

Description

AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding. (IC50: 1.0 ± 0.2 μM) It is a acid-suppressing agents with rapid onset of action and potent acid inhibition. In vitro: AZD0865 can inhibit the final step in acid secretion. AZD0865 reduced porcine renal Na+,K+-ATPase activity by 9 ± 2%, demonstrating a high selectivity for H+,K+-ATPase. In vivo: The reference for animal administration is 0.5-1.0 mg/kg. The greater degree of acid suppression with the 75-mg dose of AZD0865 would translate to a healing rate of 89% at 4 weeks.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (95.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7288 mL 13.6441 mL 27.2881 mL
5 mM 0.5458 mL 2.7288 mL 5.4576 mL
10 mM 0.2729 mL 1.3644 mL 2.7288 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

366.46

Formula

C₂₁H₂₆N₄O₂

CAS No.

248919-64-4

SMILES

O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3C)=C1)=NC(C)=C2C)NCCO

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AZD0865
Cat. No.:
HY-100412
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AZD0865

Cat. No.: HY-100412