Boc-Gln-Gly-Arg-AMC

Name: Boc-Gln-Gly-Arg-AMC
Brand: MedChemExpress
SKU: HY-P4331
Rating: 4.5 (1 reviews)

Cat. No.: HY-P4331 Purity: 99.77%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for kallikrein (PKa), coagulation factor XIIa (FXIIa) and coagulation factor XIa (FXIa). Boc-Gln-Gly-Arg-AMC enables fluorescence-based activity assays for PKa, FXIIa and FXIa.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Boc-Gln-Gly-Arg-AMC Chemical Structure

CAS No. : 113865-85-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Boc-Gln-Gly-Arg-AMC (100 μM; 150 minutes) detects FXIIa activity generated by RBC-MVs incubated with purified human FXII over 150 minutes via substrate cleavage-induced fluorescence^[1].
Boc-Gln-Gly-Arg-AMC (100 μM; 150 minutes) detects PKa activity generated by RBC-MVs incubated with purified human PK and HK over 150 minutes via substrate cleavage-induced fluorescence^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

616.67

Formula

C₂₈H₄₀N₈O₈

CAS No.

113865-85-3

Appearance

Solid

Color

White to off-white

Sequence

{Boc-Gln}-Gly-{Arg-AMC}

Sequence Shortening

{Boc-Gln}-G-{Arg-AMC}

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (162.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6216 mL	8.1081 mL	16.2161 mL
5 mM	0.3243 mL	1.6216 mL	3.2432 mL
10 mM	0.1622 mL	0.8108 mL	1.6216 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.77%

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Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) LCMS (93 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Noubouossie DF, et al. Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways. Blood. 2020;135(10):755-765. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6216 mL	8.1081 mL	16.2161 mL	40.5403 mL
	5 mM	0.3243 mL	1.6216 mL	3.2432 mL	8.1081 mL
	10 mM	0.1622 mL	0.8108 mL	1.6216 mL	4.0540 mL
	15 mM	0.1081 mL	0.5405 mL	1.0811 mL	2.7027 mL
	20 mM	0.0811 mL	0.4054 mL	0.8108 mL	2.0270 mL
	25 mM	0.0649 mL	0.3243 mL	0.6486 mL	1.6216 mL
	30 mM	0.0541 mL	0.2703 mL	0.5405 mL	1.3513 mL
	40 mM	0.0405 mL	0.2027 mL	0.4054 mL	1.0135 mL
	50 mM	0.0324 mL	0.1622 mL	0.3243 mL	0.8108 mL
	60 mM	0.0270 mL	0.1351 mL	0.2703 mL	0.6757 mL
	80 mM	0.0203 mL	0.1014 mL	0.2027 mL	0.5068 mL
	100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.4054 mL