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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
Kallikrein
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "Kallikrein" in MCE Product Catalog:
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20 Publications Verification
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AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
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Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research .
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1 Cited Publications
Cat. No.: HY-P4245
CAS No.: 88546-74-1
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Sebetralstat (KVD900) is an orally active and selective plasma kallikrein inhibitor, with an IC50 of 6.0 nM and a Ki of 3.0 nM against the human target. Sebetralstat binds to the active site of plasma kallikrein, inducing a conformational flip of Trp215 to form a U-shaped conformation; its P1 group interacts with the S1 pocket through hydrophobic interactions and displacement of high-energy water molecules, independent of the Asp189 ionic bond. Sebetralstat inhibits plasma kallikrein-kinin system activation in whole plasma, rapidly relieves laryngeal and abdominal attack symptoms of hereditary angioedema (HAE-C1INH), and reduces attack severity. Sebetralstat can be used in research related to hereditary angioedema (HAE) .
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Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema .
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1 Cited Publications
Synonyms: BCX7353 dihydrochloride
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Berotralstat dihydrochloride (BCX7353 dihydrochloride) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema .
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1 Cited Publications
Cat. No.: HY-P71590
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KLK14; Kallikrein-Related Peptidase 14 Transcript Variant 2; Kallikrein Related Peptidase 14; Kallikrein-Related Peptidase 14 Transcript Variant 3; KLK-L6; Kallikrein 14; Kallikrein-Like Protein 6; KLKL6; Kallikrein-14; HK14
Species:
Mouse
Source:
E. coli
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1 Cited Publications
Cat. No.: HY-P70606A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK3; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_e; Prev. APS; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_d; PSA; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_f; Prostate Specific Antigen; Kallikrein 3, (Prostate Specific
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70266
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK3; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_e; Prev. APS; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_d; PSA; Kallikrein 3, (Prostate Specific Antigen), Isoform CRA_f; Prostate Specific Antigen; Kallikrein 3, (Prostate Specific
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71143
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA4; Testicular Secretory Protein Li 22; Prev. PI4; Peptidase Inhibitor 4; KST; Kallikrein Inhibitor; Kallistatin; Serpin A4; KLST; PI-4; KAL; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4, Isoform CRA_a; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4; Protease Inhibitor 4 (Kallistatin); Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4; Serpin Family A Member 4; Sserpin Family A Member 4
Species:
Human
Source:
HEK293
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Kallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC50=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching .
Cat. No.: HY-P2618
CAS No.: 2237216-30-5
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Cat. No.: HY-137199
CAS No.: 65147-21-9
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Cat. No.: HY-P99110
CAS No.: 1426055-14-2
Synonyms: SHP643; DX-2930; X124-G01
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Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC50 of 0.016 μM against human plasma kallikrein .
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Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively .
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PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system .
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PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
