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Art. -Nr.: HY-124577

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MDI-2268

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MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.73%
CAS. Nr.: 1609176-50-2
Formel: C₁₀H₁₀F₃N₃O₃
Molecular Weight:277.20

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MDI-2268 Chemical Structure

CAS. Nr.: 1609176-50-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

MDI-2268 (1 mM, 3 days) prevents Paneth cell defects and apoptosis in Atg16l1 T300A organoids^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[2]

Cell Line:

Atg16l1 T300A organoids
Concentration:

1 mM
Incubation Time:

3 days
Result:

Reduced the cleaved caspase 3.

In Vivo

MDI-2268 (1.5-3 mg/kg, ip, every 8 hours for 6 doses) exhibits antithrombotic effect in mouse electrolytic inferior vena cava (IVC) models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse electrolytic IVC models^[1]
Dosage:

1.5-3 mg/kg
Administration:

ip, every 8 hours for 6 doses
Result:

Reduced the thrombus weight.

Chemical Information

CAS. Nr. 1609176-50-2
Appearance Solid
Molecular Weight 277.20
Formel C₁₀H₁₀F₃N₃O₃
Color White to off-white
SMILES

O=C(NN)C(NCC1=CC=CC(OC(F)(F)F)=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 166.67 mg/mL (601.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6075 mL

18.0375 mL

36.0750 mL

5 mM

0.7215 mL

3.6075 mL

7.2150 mL

10 mM

0.3608 mL

1.8038 mL

3.6075 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gordon A, et al. Natural History of Stasis-Induced Deep Venous Thrombosis in a Murine Model and Application in the Clinical Setting: A Histochemical Approach[J]. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 2020, 8(2): 309.

[2]. Sun S, et al., Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction. Sci Immunol. 2024 Nov 8;9(101):eadi7907. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.6075 mL	18.0375 mL	36.0750 mL	90.1876 mL
	5 mM	0.7215 mL	3.6075 mL	7.2150 mL	18.0375 mL
	10 mM	0.3608 mL	1.8038 mL	3.6075 mL	9.0188 mL
	15 mM	0.2405 mL	1.2025 mL	2.4050 mL	6.0125 mL
	20 mM	0.1804 mL	0.9019 mL	1.8038 mL	4.5094 mL
	25 mM	0.1443 mL	0.7215 mL	1.4430 mL	3.6075 mL
	30 mM	0.1203 mL	0.6013 mL	1.2025 mL	3.0063 mL
	40 mM	0.0902 mL	0.4509 mL	0.9019 mL	2.2547 mL
	50 mM	0.0722 mL	0.3608 mL	0.7215 mL	1.8038 mL
	60 mM	0.0601 mL	0.3006 mL	0.6013 mL	1.5031 mL
	80 mM	0.0451 mL	0.2255 mL	0.4509 mL	1.1273 mL
	100 mM	0.0361 mL	0.1804 mL	0.3608 mL	0.9019 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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MDI-2268

Anti-Cardiovascular Disease Compound Library

Angiogenesis-Related Compound Library

Coagulation and Anti-coagulation Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Metabolism/Protease Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MDI-2268

Anti-Cardiovascular Disease Compound Library

Angiogenesis-Related Compound Library

Coagulation and Anti-coagulation Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Metabolism/Protease Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MDI-2268 Related Classifications

HY-124577 Related Classifications