2. Immunology/Inflammation
  3. Kallikrein
  4. GSK951

GSK951 is a potent and selective Kallikrein-5 (KLK5) inhibitor amenable to epidermal delivery. GSK951 shows an IC50 of 250 pM for KLK5 and greater than 100-fold selectivity over KLK7 and KLK14. GSK951 can reduce transepidermal water loss, and decrease proinflammatory cytokine expression. GSK951 can be used for the researches of inflammation and immunology, such as Netherton syndrome.

For research use only. We do not sell to patients.

GSK951

GSK951 Chemical Structure

CAS No. : 2393881-77-9

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GSK951 Related Antibodies

Top Publications Citing Use of Products

View All Kallikrein Isoform Specific Products:

View All Isoforms
KLK1 KLK5 KLK8 KLK14 KLKB1 KLK10

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Description

GSK951 is a potent and selective Kallikrein-5 (KLK5) inhibitor amenable to epidermal delivery. GSK951 shows an IC50 of 250 pM for KLK5 and greater than 100-fold selectivity over KLK7 and KLK14. GSK951 can reduce transepidermal water loss, and decrease proinflammatory cytokine expression. GSK951 can be used for the researches of inflammation and immunology, such as Netherton syndrome[1].

IC50 & Target[1]

KLK5

250 pM (IC50)

Molecular Weight

441.21

Formula

C22H19BF3N3O3
CAS No.
SMILES

OB1C2=CC(C(F)(F)F)=CC=C2C[C@@](C3=CC(OCC4=CN=CC=C4)=C(C=C3)C(N)=N)([H])O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK951 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK9512393881-77-9GSK 951GSK-951KallikreinKLKKallikrein-related peptidaseInhibitorinhibitorinhibit

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