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Art. -Nr.: HY-181798

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pKal-IN-1

pKal-IN-1 (compound 13) is a plasma kallikrein (pKal) inhibitor. pKal-IN-1 can be used for the research of diabetic macular edema, diabetic retinopathy.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2773609-90-6
Formel: C₂₀H₂₀ClF₄N₅O₃
Molecular Weight:489.85

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

pKal-IN-1 Chemical Structure

CAS. Nr.: 2773609-90-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

pKal-IN-1 (compound 13) is a plasma kallikrein (pKal) inhibitor. pKal-IN-1 can be used for the research of diabetic macular edema, diabetic retinopathy^[1].

Alle Kallikrein Isoform-spezifische Produkte anzeigen :

In Vitro

pKal-IN-1 (compound 13) potently inhibits plasma kallikrein with an IC₅₀ of 0.7 nM^[1].
pKal-IN-1 does not exhibit time-dependent inhibition of CYP3A4, with a TDI ratio of ~1^[1].
pKal-IN-1 does not significantly inhibit hERG, with an IC₅₀ >60 μM^[1].
pKal-IN-1 activates PXR with an EC₅₀ of 7.9 μM and a maximum effect of 109%^[1].
pKal-IN-1 inhibits CYP2C9 with an IC₅₀ of 13 μM, but does not significantly inhibit CYP2D6 or CYP2C8^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2773609-90-6
Molecular Weight 489.85
Formel C₂₀H₂₀ClF₄N₅O₃
SMILES

O=C1O[C@@]2(CN(C(C3=C(N)N([C@@H](CC)C(F)(F)F)N=C3)=O)CCC2)C4=C(F)C(Cl)=CC=C4N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Merchant RR, et al. N‑Alkyl and N‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors. ACS Med Chem Lett. 2026;17(3):744-749. Published 2026 Feb 24. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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