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Cat. No.: HY-181798

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pKal-IN-1

pKal-IN-1 (compound 13) is a plasma kallikrein (pKal) inhibitor. pKal-IN-1 can be used for the research of diabetic macular edema, diabetic retinopathy.

For research use only. We do not sell to patients.

CAS No.: 2773609-90-6
Formula: C₂₀H₂₀ClF₄N₅O₃
Molecular Weight:489.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

pKal-IN-1 Chemical Structure

CAS No.: 2773609-90-6

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

pKal-IN-1 (compound 13) is a plasma kallikrein (pKal) inhibitor. pKal-IN-1 can be used for the research of diabetic macular edema, diabetic retinopathy^[1].

All Kallikrein Isoforms :

In Vitro

pKal-IN-1 (compound 13) potently inhibits plasma kallikrein with an IC₅₀ of 0.7 nM^[1].
pKal-IN-1 does not exhibit time-dependent inhibition of CYP3A4, with a TDI ratio of ~1^[1].
pKal-IN-1 does not significantly inhibit hERG, with an IC₅₀ >60 μM^[1].
pKal-IN-1 activates PXR with an EC₅₀ of 7.9 μM and a maximum effect of 109%^[1].
pKal-IN-1 inhibits CYP2C9 with an IC₅₀ of 13 μM, but does not significantly inhibit CYP2D6 or CYP2C8^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2773609-90-6
Molecular Weight 489.85
Formula C₂₀H₂₀ClF₄N₅O₃
SMILES

O=C1O[C@@]2(CN(C(C3=C(N)N([C@@H](CC)C(F)(F)F)N=C3)=O)CCC2)C4=C(F)C(Cl)=CC=C4N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Merchant RR, et al. N‑Alkyl and N‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors. ACS Med Chem Lett. 2026;17(3):744-749. Published 2026 Feb 24. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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pKal-IN-1

All Kallikrein Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

pKal-IN-1 Related Classifications

HY-181798 Related Classifications