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Berotralstat 

Cat. No.: HY-109127
Handling Instructions

Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE.

For research use only. We do not sell to patients.

Berotralstat Chemical Structure

Berotralstat Chemical Structure

CAS No. : 1809010-50-1

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Description

Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE[1][2].

IC50 & Target

Plasma kallikrein[1]

Molecular Weight

562.56

Formula

C₃₀H₂₆F₄N₆O

CAS No.
SMILES

O=C(C1=CC(C(F)(F)F)=NN1C2=CC(CN)=CC=C2)NC3=CC([[email protected]@H](C4=CC(C#N)=CC=C4)NCC5CC5)=CC=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BerotralstatOthersSafeEffectiveSpecificSecond-generationSyntheticOralSwellInhibitorinhibitorinhibit

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