2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. Sebetralstat

Sebetralstat  (Synonyms: KVD900)

Cat. No.: HY-132830 Purity: 97.01%
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Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases.

For research use only. We do not sell to patients.

Sebetralstat Chemical Structure

Sebetralstat Chemical Structure

CAS No. : 1933514-13-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 154 In-stock
Solution
10 mM * 1 mL in DMSO USD 154 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 220 In-stock
25 mg USD 400 In-stock
50 mg USD 590 In-stock
100 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Sebetralstat Related Antibodies

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  • Biological Activity

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Description

Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases[1].

IC50 & Target

Plasma Kallikrein[1]
In Vitro

Sebetralstat is a plasma kallikrein inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sebetralstat Related Antibodies
Clinical Trial
Molecular Weight

491.51

Formula

C26H26FN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=CC=CN1CC2=CC=C(CN3N=C(COC)C(C(NCC4=NC=CC(OC)=C4F)=O)=C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (254.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0345 mL 10.1727 mL 20.3455 mL
5 mM 0.4069 mL 2.0345 mL 4.0691 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0345 mL 10.1727 mL 20.3455 mL 50.8637 mL
5 mM 0.4069 mL 2.0345 mL 4.0691 mL 10.1727 mL
10 mM 0.2035 mL 1.0173 mL 2.0345 mL 5.0864 mL
15 mM 0.1356 mL 0.6782 mL 1.3564 mL 3.3909 mL
20 mM 0.1017 mL 0.5086 mL 1.0173 mL 2.5432 mL
25 mM 0.0814 mL 0.4069 mL 0.8138 mL 2.0345 mL
30 mM 0.0678 mL 0.3391 mL 0.6782 mL 1.6955 mL
40 mM 0.0509 mL 0.2543 mL 0.5086 mL 1.2716 mL
50 mM 0.0407 mL 0.2035 mL 0.4069 mL 1.0173 mL
60 mM 0.0339 mL 0.1695 mL 0.3391 mL 0.8477 mL
80 mM 0.0254 mL 0.1272 mL 0.2543 mL 0.6358 mL
100 mM 0.0203 mL 0.1017 mL 0.2035 mL 0.5086 mL
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Sebetralstat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sebetralstat1933514-13-6KVD900KVD 900KVD-900Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesplasmakallikreindiabeticretinopathymacularedemaInhibitorinhibitorinhibit

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