Kallikrein 5-IN-2 TFA
Based on 1 Customer Validation
Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC50 of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome.
For research use only. We do not sell to patients.
- Purity: 99.53%
- Formula: C25H23F3N6O3
- Molecular Weight:512.48
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KLK5 7.1 (pIC50) |
KLK8 6.1 (pIC50) |
KLK14 5.4 (pIC50) |
KLKB1 5.2 (pIC50) |
KLK1 4.2 (pIC50) |
Chemical Information
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Appearance Solid
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Molecular Weight 512.48
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Formula C25H23F3N6O3
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Color Off-white to yellow
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SMILES
N=C(C1=CC=C(NCC2=NC=C(C3=CC=CC=C3)N2)C=C1OCC4=CC=CN=C4)N.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (195.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9513 mL | 9.7565 mL | 19.5130 mL | 48.7824 mL |
| 5 mM | 0.3903 mL | 1.9513 mL | 3.9026 mL | 9.7565 mL | |
| 10 mM | 0.1951 mL | 0.9756 mL | 1.9513 mL | 4.8782 mL | |
| 15 mM | 0.1301 mL | 0.6504 mL | 1.3009 mL | 3.2522 mL | |
| 20 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4391 mL | |
| 25 mM | 0.0781 mL | 0.3903 mL | 0.7805 mL | 1.9513 mL | |
| 30 mM | 0.0650 mL | 0.3252 mL | 0.6504 mL | 1.6261 mL | |
| 40 mM | 0.0488 mL | 0.2439 mL | 0.4878 mL | 1.2196 mL | |
| 50 mM | 0.0390 mL | 0.1951 mL | 0.3903 mL | 0.9756 mL | |
| 60 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8130 mL | |
| 80 mM | 0.0244 mL | 0.1220 mL | 0.2439 mL | 0.6098 mL | |
| 100 mM | 0.0195 mL | 0.0976 mL | 0.1951 mL | 0.4878 mL |
Kallikrein 5-IN-2 TFA Related Classifications
HY-148949A Related Classifications
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