2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. REGN9533

REGN9533 is a human-derived monoclonal antibody against FXII/FXIIa with high affinity for FXII, FXIIa and β-FXIIa. REGN9533 selectively inhibits the intrinsic coagulation pathway and FXIIa-driven plasma kallikrein activity. REGN9533 is applicable to FXIIa-related diseases such as thrombosis and hereditary angioedema.

For research use only. We do not sell to patients.

REGN9533

REGN9533 Chemical Structure

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REGN9533 Related Antibodies

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Description

REGN9533 is a human-derived monoclonal antibody against FXII/FXIIa with high affinity for FXII, FXIIa and β-FXIIa. REGN9533 selectively inhibits the intrinsic coagulation pathway and FXIIa-driven plasma kallikrein activity. REGN9533 is applicable to FXIIa-related diseases such as thrombosis and hereditary angioedema[1].

Species Reactivity

Human
In Vitro

REGN9533 exhibits high binding affinity to human FXII, FXIIa and β-FXIIa proteins, with dissociation constants of 0.23, 0.32 and 0.26 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

REGN9533 Related Antibodies
Gene ID

````````````````````````````````````````````````````````````````````````````````````````````````````  [NCBI]

Accession
Target

F12/Factor XII
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[REGN9533]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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REGN9533 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

REGN9533REGN 9533REGN-9533Factor XaFxaβ-FXIIaCyno plasmahuman FXIIcontact pathway-driven coagulationplasma kallikreinhuman plasmaextrinsic coagulation pathwayFXIIaInhibitorinhibitorinhibit

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