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  3. Hydrolases (EC 3)
  4. Kallikrein-15 Protein, Human (HEK293, His)

Kallikrein-15 Protein, Human (HEK293, His)

Cat. No.: HY-P77048
COA Handling Instructions

Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kallikrein-15 Protein, Human (HEK293, His) is 240 a.a., with molecular weight of ~27.8 KDa.

For research use only. We do not sell to patients.

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Description

Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag. The total length of Kallikrein-15 Protein, Human (HEK293, His) is 240 a.a., with molecular weight of ~27.8 KDa.

Background

Kallikrein-15 (KLK15) is a kallikrein (KLK). Previous research has suggested that KLK15 may play a role in prostate cancer. Chemical analysis of immunohistology of testes showed that KLK15 is strongly expressed in mature sperm cells but not in immature germ cells. The subcellular localization of KLK15 in the basal cell layer of the prostate epithelium is primarily in the nucleus. KLK15 also has trypsin-like activity and preferentially cleaves after arginine (R). KLK15 may be able to cleave many extracellular matrix (ECM) components, functionally similar to some KLK family members. The enzymatic activity of KLK15 is regulated by different factors such as pH, cations, and serine protease inhibitors. Notably, KLK15 is most likely associated with tumorigenesis by interacting with the extracellular matrix (ECM) receptor group and may promote metastasis through this mechanism.

Biological Activity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q9H2R5/NP_059979.2 (Q17-N256)

Gene ID
Molecular Construction
N-term
Kallikrein-15 (Q17-N256)
Accession # Q9H2R5/NP_059979.2
His
C-term
Synonyms
ACO protease; KLK15; kallikrein-related peptidase 15
Molecular Weight

Approximately 27.8 kDa.

Purity

Greater than 85% as determined by reducing SDS-PAGE.

Appearance

Solution

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

Kallikrein-15 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Kallikrein-15 Protein, Human (HEK293, His)
Cat. No.:
HY-P77048
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