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Kallikrein-15 Protein, Human (HEK293, His, solution)

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Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His, solution) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His, solution) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag.

Background

Kallikrein-15 (KLK15) is a kallikrein (KLK). Previous research has suggested that KLK15 may play a role in prostate cancer. Chemical analysis of immunohistology of testes showed that KLK15 is strongly expressed in mature sperm cells but not in immature germ cells. The subcellular localization of KLK15 in the basal cell layer of the prostate epithelium is primarily in the nucleus. KLK15 also has trypsin-like activity and preferentially cleaves after arginine (R). KLK15 may be able to cleave many extracellular matrix (ECM) components, functionally similar to some KLK family members. The enzymatic activity of KLK15 is regulated by different factors such as pH, cations, and serine protease inhibitors. Notably, KLK15 is most likely associated with tumorigenesis by interacting with the extracellular matrix (ECM) receptor group and may promote metastasis through this mechanism.

Verified Bioactivity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-His
  • Accession

    Q9H2R5-1/NP_059979.2 (Q17-N256)

  • Gene ID
    55554  [NCBI]
  • Molecular Construction
    • N-term
    • Kallikrein-15 (Q17-N256)
      Accession # Q9H2R5-1/NP_059979.2
    • His
    • C-term
  • Protein Length

    Full Length of Isoform-1 (with Propeptide)

  • Synonyms

    KLK15; Kallikrein 15 Isoform 5 Preproprotein; Kallikrein Related Peptidase 15; Kallikrein-Like Serine Protease; HSRNASPH; Kallikrein-Related Peptidase 9; ACO; Kallikrein 15, Isoform CRA_c; Prostinogen; Kallikrein 15, Isoform CRA_b; Kallikrein-15; Kallikre

  • AA Sequence

    QDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRN

  • Predicted Molecular Mass

    27.8 kDa

  • Glycosylation

    Yes

  • Purity

    ≥ 85%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Formulation

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
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MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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