KLK15 - kallikrein related peptidase 15 Gene

Also Known as ACO; HSRNASPH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55554

About KLK15

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,825,289-50,833,574 (from NCBI)

This gene has 11 transcripts (splice variants), 436 orthologues and 14 paralogues. Biased expression in colon (RPKM 1.2), testis (RPKM 1.0) and 5 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. In prostate Cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate Cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KLK15 Products (3)

mRNA Protein Name
NM_001277081.2 NP_001264010.1 kallikrein-15 isoform 5 preproprotein
NM_001277082.2 NP_001264011.1 kallikrein-15 isoform 6 preproprotein
NM_017509.4 NP_059979.2 kallikrein-15 isoform 4 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK15 Protein Structure

Trypsin

Trypsin: Trypsin (24 - 249)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

kallikrein-15

  • ACO protease

KLK15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLK15 Q9H2R5 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra
KLK15 Q9H2R5 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra
KLK15 Q9H2R5 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
KLK15 Q9H2R5 TRIP6 Homo sapiens Q15654
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLK15 Proteins

Cat. No. Product Name Accession Purity
HY-P77047 Kallikrein-15 Protein, Human (HEK293, Fc) Q9H2R5-1/NP_059979.2 (Q17-N256) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P77048 Kallikrein-15 Protein, Human (HEK293, His, solution) Q9H2R5-1/NP_059979.2 (Q17-N256) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Deafness, Autosomal Recessive 100

  • DFNB100

  • Autosomal Recessive Nonsyndromic Deafness 100

  • Autosomal Recessive Deafness 100

  • Deafness, Autosomal Recessive, 100
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07379 KLK15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20047 Klk15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26551 Klk15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KLK15 RGD RGD:1310995
Bos taurus KLK15 VGNC VGNC:30677
Mus musculus KLK15 MGD MGI:2447533
Macaca mulatta KLK15 VGNC VGNC:84893
Others KLK15 NCBI