KLK15 - kallikrein related peptidase 15 Gene

Homo sapiens

Also known as ACO; HSRNASPH

Gene ID: 55554 | Gene type: protein coding

About KLK15

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,825,289-50,833,574 (from NCBI)

This gene has 11 transcripts (splice variants), 436 orthologues and 14 paralogues. Biased expression in colon (RPKM 1.2), testis (RPKM 1.0) and 5 other tissues.

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. In prostate Cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate Cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KLK15 Products(3)

mRNA	Protein	Name
NM_001277081.2	NP_001264010.1	kallikrein-15 isoform 5 preproprotein
NM_001277082.2	NP_001264011.1	kallikrein-15 isoform 6 preproprotein
NM_017509.4	NP_059979.2	kallikrein-15 isoform 4 preproprotein

KLK15 Protein Structure

Trypsin

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

kallikrein-15

ACO protease

Recombinant KLK15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77047	Kallikrein-15 Protein, Human (HEK293, Fc)	Q9H2R5/NP_059979.2 (Q17-N256)	≥95%
HY-P77048	Kallikrein-15 Protein, Human (HEK293, His)	Q9H2R5/NP_059979.2 (Q17-N256)	≥95%

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Deafness, Autosomal Recessive 100

DFNB100	Autosomal Recessive Nonsyndromic Deafness 100
Autosomal Recessive Deafness 100	Deafness, Autosomal Recessive, 100

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07379	KLK15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLK15	RGD	RGD:1310995
Bos taurus	KLK15	VGNC	VGNC:30677
Mus musculus	KLK15	MGD	MGI:2447533
Macaca mulatta	KLK15	VGNC	VGNC:84893
Others	KLK15	NCBI

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