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DYNLT1 - dynein light chain Tctex-type 1 Gene

Also Known as CW-1; TCTEL1; TCTEX1; tctex-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6993

About DYNLT1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:158,636,474-158,644,743 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 62.3), colon (RPKM 58.0) and 25 other tissues.

Summary

This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with Viral Proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

DYNLT1 Products (3)

mRNA	Protein	Name
NM_001291602.2	NP_001278531.1	dynein light chain Tctex-type 1 isoform 2
NM_001291603.2	NP_001278532.1	dynein light chain Tctex-type 1 isoform 3
NM_006519.4	NP_006510.1	dynein light chain Tctex-type 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17965411	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644691	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular transport of viral protein in host cell	IMP IMP: Inferred from mutant phenotype	18647839	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25205765	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	21262767	GOA
part of dynein complex	IPI IPI: Inferred from physical interaction	24986880	GOA
located in secretory vesicle	IDA IDA: Inferred from direct assay	21262767	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLT1 Protein Structure

Tctex-1

0
100
113 a.a.

Protein Preferred Names	Protein Names
dynein light chain Tctex-type 1	T-complex testis-specific protein 1 homolog

DYNLT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DYNLT1	P63172	PELO	Homo sapiens	Q9BRX2	Validated Y2H	32296183
Intra	DYNLT1	P63172	HSPB9	Homo sapiens	Q9BQS6	Y2H	15503857
Intra	DYNLT1	P63172	HSPB9	Homo sapiens	Q9BQS6	Anti Bait CoIP	15503857
Intra	DYNLT1	P63172	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	DYNLT1	P63172	ARID4B	Homo sapiens	Q4LE39-3	Validated Y2H	32296183
Intra	DYNLT1	P63172	OLFM3	Homo sapiens	Q96PB7-3	Validated Y2H	32296183
Intra	DYNLT1	P63172	ACOX2	Homo sapiens	Q99424	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNC1I2	Homo sapiens	Q13409-3	Validated Y2H	32296183
Intra	DYNLT1	P63172	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNLT2B	Homo sapiens	Q8WW35	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNLT2B	Homo sapiens	Q8WW35	TAP	27173435
Intra	DYNLT1	P63172	CCDC68	Homo sapiens	Q9H2F9	Validated Y2H	32296183
Intra	DYNLT1	P63172	NHSL2	Homo sapiens	Q5HYW2	Validated Y2H	32296183
Intra	DYNLT1	P63172	UXT	Homo sapiens	Q9UBK9	Validated Y2H	32296183
Intra	DYNLT1	P63172	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	DYNLT1	P63172	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	DYNLT1	P63172	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	DYNLT1	P63172	HSPB7	Homo sapiens	Q9UBY9	Validated Y2H	32296183
Intra	DYNLT1	P63172	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	DYNLT1	P63172	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	DYNLT1	P63172	DYNLT3	Homo sapiens	P51808	TAP	27173435
Intra	DYNLT1	P63172	RRAGA	Homo sapiens	Q7L523	Validated Y2H	32296183
Intra	DYNLT1	P63172	KLK15	Homo sapiens	Q9H2R5	Validated Y2H	32296183
Intra	DYNLT1	P63172	AARSD1	Homo sapiens	Q9BTE6-2	Validated Y2H	32296183
Intra	DYNLT1	P63172	MARK1	Homo sapiens	Q9P0L2	Validated Y2H	32296183
Cross	DYNLT1	P63172	gag	Mason-Pfizer monkey virus	P07567	Anti Bait CoIP	18647839

Cross: Cross-species interaction Intra: Intraspecies interaction

DYNLT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83518	Dynein Light Chain Tctex Type 1 Antibody (YA3263)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P83518A	Dynein Light Chain Tctex Type 1 Antibody (YA3263)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Glaucomatocyclitic Crisis	Posner-Schlossman Syndrome Terrien-Viel Syndrome
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Nonparalytic Poliomyelitis	Acute Nonparalytic Poliomyelitis Non-Paralytic Aseptic Meningitis
Neutrophilic Dermatosis, Acute Febrile	Sweet Syndrome Acute Febrile Neutrophilic Dermatosis Ss AFND Pyrin-Associated Autoinflammatory Disease PAAND Gomm-Button Disease Sweet'S Syndrome Gomm Button Disease Sweets Syndrome Acromelic Frontonasal Dysostosis Sweet Disease
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Dermatitis, Atopic, 3	ATOD3 Dermatitis, Atopic, Susceptibility To, 3 Atopic Dermatitis 3 Dermatitis, Atopic, With Asthma Dermatitis, Atopic 3 Atopic Dermatitis With Asthma
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04092	DYNLT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DYNLT1	VGNC	VGNC:81062
Felis catus	DYNLT1	VGNC	VGNC:61684
Rattus norvegicus	DYNLT1	RGD	RGD:620261
Canis familiaris	DYNLT1	VGNC	VGNC:54841
Others	DYNLT1	NCBI