DYNLT3 - dynein light chain Tctex-type 3 Gene

Also Known as RP3; TCTE1L; TCTEX1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6990

About DYNLT3

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:37,838,836-37,847,571 (from NCBI)

Summary

This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

DYNLT3 Products (1)

mRNA Protein Name
NM_006520.3 NP_006511.1 dynein light chain Tctex-type 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
11425878 GOA
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
17289665 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLT3 Protein Structure

Tctex-1

Tctex-1: Tctex-1 family (16 - 114)

  • 0
  • 100
  • 116 a.a.
Protein Preferred Names Protein Names

dynein light chain Tctex-type 3

  • protein 91/23

DYNLT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DYNLT3 P51808 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra
DYNLT3 P51808 DYNLT1 Homo sapiens P63172
Validated Y2H
32296183
Intra
DYNLT3 P51808 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra
DYNLT3 P51808 DYNC1I2 Homo sapiens Q13409-3
Validated Y2H
32296183
Intra
DYNLT3 P51808 ZC3H14 Homo sapiens Q6PJT7-6
Y2H Prey Pooling
32296183
Intra
DYNLT3 P51808 ZC3H14 Homo sapiens Q6PJT7-6
Y2H Array
32296183
Intra
DYNLT3 P51808 ZC3H14 Homo sapiens Q6PJT7-6
Validated Y2H
32296183
Intra
DYNLT3 P51808 PMS1 Homo sapiens P54277-2
Validated Y2H
32296183
Intra
DYNLT3 P51808 C2orf15 Homo sapiens Q8WU43
Validated Y2H
32296183
Intra
DYNLT3 P51808 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
Intra
DYNLT3 P51808 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
25416956
Intra
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Array
32296183
Intra
DYNLT3 P51808 CCL28 Homo sapiens Q9NRJ3
Validated Y2H
32296183
Intra
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Pooling
16189514
Intra
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Validated Y2H
32296183
Intra
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Prey Pooling
32296183
Intra
DYNLT3 P51808 DYNLT3 Homo sapiens P51808
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mcleod Syndrome

  • Mcleod Neuroacanthocytosis Syndrome

  • MLS

  • X-Linked Mcleod Syndrome

  • Mcleod Phenotype

  • Neuroacanthocytosis, Mcleod Type

  • Mcleod Syndrome With Or Without Chronic Granulomatous Disease

  • MCLDS

  • Mcleod Type Neuroacanthocytosis

  • Mcleod Syndrome With Chronic Granulomatous Disease

  • Neuroacanthocytosis Mcleod Type

  • Blood Group Deletion Syndrome
Bardet-Biedl Syndrome 7

  • BBS7

  • Bardet-Biedl Syndrome, Type 7
Neuroacanthocytosis

  • Neuroacanthocytosis Syndrome
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Asphyxiating Thoracic Dystrophy

  • Jeune Thoracic Dystrophy

  • Jeune Syndrome

  • Asphyxiating Thoracic Dysplasia

  • Short-Rib Thoracic Dysplasia With Or Without Polydactyly

  • Thoracic Pelvic Phalangeal Dystrophy

  • Asphyxiating Thoracic Chondrodystrophy

  • Atd

  • Chondroectodermal Dysplasia-Like Syndrome

  • Infantile Thoracic Dystrophy

  • Jeune Thoracic Dysplasia

  • Thoracic Asphyxiant Dystrophy

  • Thoracic-Pelvic-Phalangeal Dystrophy

  • Short-Rib Thoracic Dysplasia Without Polydactyly

  • Asphyxiating Thoracic Dystrophy Of The Newborn

  • Asphyxiating Thorax Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04093 DYNLT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DYNLT3 VGNC VGNC:106439
Canis familiaris DYNLT3 VGNC VGNC:40154
Bos taurus DYNLT3 VGNC VGNC:28278
Rattus norvegicus DYNLT3 RGD RGD:1549755
Mus musculus DYNLT3 MGD MGI:1914367
Others DYNLT3 NCBI