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RRAGA - Ras related GTP binding A Gene

Also Known as FIP1; RAGA; FIP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10670

About RRAGA

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,049,427-19,051,025 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues, 3 paralogues and is associated with 1 phenotype.

Summary

Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Colocalizes with GATOR1 complex. [provided by Alliance of Genome Resources, Apr 2022]

RRAGA Products (1)

mRNA	Protein	Name
NM_006570.5	NP_006561.1	ras-related GTP-binding protein A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	7499430	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	31601708	GOA
enables phosphoprotein binding	IDA IDA: Inferred from direct assay	8995684	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8995684	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11073942	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	14660641	GOA
enables protein-membrane adaptor activity	IDA IDA: Inferred from direct assay	31601708	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25936802	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	25936802	GOA
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	31601708	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9394008	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25936802	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	31601708	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	25936802	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in protein localization to lysosome	IDA IDA: Inferred from direct assay	31601708	GOA
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	31601708	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	8995684	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
part of GATOR1 complex	IDA IDA: Inferred from direct assay	25936802	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9394008	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	31601708	GOA
located in lysosome	IDA IDA: Inferred from direct assay	20381137	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	8995684	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9394008	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAGA Protein Structure

Gtr1_RagA

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
ras-related GTP-binding protein A	adenovirus E3 14.7 kDa-interacting protein 1

RRAGA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RRAGA	Q7L523	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	RRAGA	Q7L523	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	RRAGA	Q7L523	LAMTOR1	Homo sapiens	Q6IAA8	Anti Bait CoIP	25561175
Intra	RRAGA	Q7L523	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25561175
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	BRET	37398436
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	33961781
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Y2H Pooling	16189514
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	28514442
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	BiLC	37398436
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	11073942
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Y2H	11073942
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	25561175
Intra	RRAGA	Q7L523	RRAGC	Homo sapiens	Q9HB90	Lumier	37398436
Intra	RRAGA	Q7L523	RRAGD	Homo sapiens	Q9NQL2	Anti Tag CoIP	25561175
Intra	RRAGA	Q7L523	RRAGD	Homo sapiens	Q9NQL2	Anti Tag CoIP	11073942
Intra	RRAGA	Q7L523	RRAGD	Homo sapiens	Q9NQL2	Anti Tag CoIP	28514442
Intra	RRAGA	Q7L523	RRAGD	Homo sapiens	Q9NQL2	Anti Tag CoIP	33961781
Intra	RRAGA	Q7L523	RRAGD	Homo sapiens	Q9NQL2	Y2H	11073942
Intra	RRAGA	Q7L523	SLC38A9	Homo sapiens	Q8NBW4	Anti Bait CoIP	32433612
Intra	RRAGA	Q7L523	SLC38A9	Homo sapiens	Q8NBW4	Anti Bait CoIP	25561175
Intra	RRAGA	Q7L523	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175
Intra	RRAGA	Q7L523	SLC38A9	Homo sapiens	Q8NBW4	Anti Bait CoIP	25567906
Intra	RRAGA	Q7L523	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Premature Ovarian Failure 18	POF18 Primary Ovarian Insufficiency 18 Ovarian Failure, Premature, Type 18
Birt-Hogg-Dube Syndrome	Hornstein-Knickenberg Syndrome Fibrofolliculomas With Trichodiscomas And Acrochordons BHD Birt-Hogg-Dubé Syndrome Multiple Fibrofolliculoma Familial Bhd Syndrome Birt Hogg Dube Syndrome Hornstein-Birt-Hogg-Dubé Syndrome Multiple Fibrofolliculomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12276	RRAGA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21744	Rraga Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28261	Rraga Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RRAGA	RGD	RGD:619804
Macaca mulatta	RRAGA	VGNC	VGNC:77031
Felis catus	RRAGA	VGNC	VGNC:64767
Mus musculus	RRAGA	MGD	MGI:1915691
Others	RRAGA	NCBI