RRAGC - Ras related GTP binding C Gene

Also Known as GTR2; RAGC; TIB929

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64121

About RRAGC

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,838,198-38,859,772 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 23.8), placenta (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

RRAGC Products (2)

mRNA Protein Name
NM_001271851.2 NP_001258780.1 ras-related GTP-binding protein C isoform 2
NM_022157.4 NP_071440.1 ras-related GTP-binding protein C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
11073942 GOA
enables GDP binding IMP
IMP: Inferred from mutant phenotype
22424946 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
11073942 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
22424946 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
11073942 GOA
enables GTPase binding IPI
IPI: Inferred from physical interaction
22424946 GOA
enables enzyme-substrate adaptor activity IDA
IDA: Inferred from direct assay
32612235 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
32612235 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11073942 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
11073942 GOA
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
31601708 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IGI
IGI: Inferred from genetic interaction
23723238 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
31601708 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
31601708 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
26691987 GOA
involved in protein localization to lysosome IDA
IDA: Inferred from direct assay
31601708 GOA
involved in protein localization to membrane IDA
IDA: Inferred from direct assay
31601708 GOA
involved in regulation of TOR signaling IGI
IGI: Inferred from genetic interaction
23723238 GOA
involved in regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
27222292 GOA
involved in response to amino acid IMP
IMP: Inferred from mutant phenotype
27222292 GOA
Cellular Component GO Annotation Evidence References Source
part of FNIP-folliculin RagC/D GAP IDA
IDA: Inferred from direct assay
32612235 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11073942 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
31601708 GOA
located in lysosome IDA
IDA: Inferred from direct assay
20381137 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11073942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAGC Protein Structure

Gtr1_RagA

Gtr1_RagA: Gtr1/RagA G protein conserved region (63 - 289)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

ras-related GTP-binding protein C

  • GTPase-interacting protein 2

RRAGC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RRAGC Q9HB90 NSL1 Homo sapiens Q96IY1
Lumier
37398436
Intra
RRAGC Q9HB90 LAMTOR1 Homo sapiens Q6IAA8
BRET
37398436
Intra
RRAGC Q9HB90 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
22424946
Intra
RRAGC Q9HB90 LAMTOR1 Homo sapiens Q6IAA8
BiLC
37398436
Intra
RRAGC Q9HB90 LAMTOR1 Homo sapiens Q6IAA8
Affinity Chrom
22980980
Intra
RRAGC Q9HB90 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25561175
Intra
RRAGC Q9HB90 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25567906
Intra
RRAGC Q9HB90 RRAGA Homo sapiens Q7L523
Y2H
11073942
Intra
RRAGC Q9HB90 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
11073942
Intra
RRAGC Q9HB90 RRAGA Homo sapiens Q7L523
Pull Down
11073942
Intra
RRAGC Q9HB90 RRAGB Homo sapiens Q5VZM2
Anti Bait CoIP
20381137
Intra
RRAGC Q9HB90 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
22424946
Intra
RRAGC Q9HB90 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
25561175
Intra
RRAGC Q9HB90 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
25567906
Intra
RRAGC Q9HB90 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25567906
Intra
RRAGC Q9HB90 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
25567906
Intra
RRAGC Q9HB90 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Birt-Hogg-Dube Syndrome

  • Hornstein-Knickenberg Syndrome

  • Fibrofolliculomas With Trichodiscomas And Acrochordons

  • BHD

  • Birt-Hogg-Dubé Syndrome

  • Multiple Fibrofolliculoma Familial

  • Bhd Syndrome

  • Birt Hogg Dube Syndrome

  • Hornstein-Birt-Hogg-Dubé Syndrome

  • Multiple Fibrofolliculomas
Retinitis Pigmentosa 60

  • RP60

  • Retinitis Pigmentosa, Type 60
Familial Renal Oncocytoma
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Fanconi Anemia, Complementation Group C

  • Fanconi Anemia Complementation Group C

  • FANCC

  • Facc

  • Fac

  • Fa3

  • Fanconi Pancytopenia Type 3

  • Fanconi Pancytopenia, Type 3

  • Faces Syndrome

  • Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

  • Friedman-Goodman Syndrome

  • Abnormality Of The Face
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12278 RRAGC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RRAGC VGNC VGNC:45756
Mus musculus RRAGC MGD MGI:1858751
Rattus norvegicus RRAGC RGD RGD:1311760
Bos taurus RRAGC VGNC VGNC:34160
Macaca mulatta RRAGC VGNC VGNC:77060
Felis catus RRAGC VGNC VGNC:64769
Others RRAGC NCBI