RRAGC - Ras related GTP binding C Gene

Homo sapiens

Also known as GTR2; RAGC; TIB929

Gene ID: 64121 | Gene type: protein coding

About RRAGC

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,838,198-38,859,772 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 23.8), placenta (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

RRAGC Products(2)

mRNA	Protein	Name
NM_001271851.2	NP_001258780.1	ras-related GTP-binding protein C isoform 2
NM_022157.4	NP_071440.1	ras-related GTP-binding protein C isoform 1

RRAGC Protein Structure

Gtr1_RagA

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

ras-related GTP-binding protein C

GTPase-interacting protein 2

Related Diseases

Diseases

Alias

Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome	Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD	Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculoma Familial	Bhd Syndrome
Birt Hogg Dube Syndrome	Hornstein-Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculomas

Retinitis Pigmentosa 60

RP60	Retinitis Pigmentosa, Type 60

Familial Renal Oncocytoma

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12278	RRAGC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RRAGC	VGNC	VGNC:45756
Mus musculus	RRAGC	MGD	MGI:1858751
Rattus norvegicus	RRAGC	RGD	RGD:1311760
Bos taurus	RRAGC	VGNC	VGNC:34160
Macaca mulatta	RRAGC	VGNC	VGNC:77060
Felis catus	RRAGC	VGNC	VGNC:64769

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