RRAGB - Ras related GTP binding B Gene

Also Known as RAGB; bA465E19.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10325

About RRAGB

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,717,749-55,758,774 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 5.3), thyroid (RPKM 4.8) and 25 other tissues.

Summary

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

RRAGB Products (4)

mRNA Protein Name
NM_001354011.2 NP_001340940.1 ras-related GTP-binding protein B isoform 3
NM_001354013.2 NP_001340942.1 ras-related GTP-binding protein B isoform 4
NM_006064.5 NP_006055.3 ras-related GTP-binding protein B short isoform
NM_016656.4 NP_057740.2 ras-related GTP-binding protein B long isoform

RRAGB Protein Structure

Gtr1_RagA

Gtr1_RagA: Gtr1/RagA G protein conserved region (42 - 296)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
Protein Preferred Names Protein Names

ras-related GTP-binding protein B

  • GTP-binding protein ragB

RRAGB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RRAGB Q5VZM2 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
25567906
Intra
RRAGB Q5VZM2 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
11073942
Intra
RRAGB Q5VZM2 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
33961781
Intra
RRAGB Q5VZM2 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
33961781
Intra
RRAGB Q5VZM2 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
20381137
Intra
RRAGB Q5VZM2 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25567906
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cystic Echinococcosis

  • Echinococcus Granulosus Infection

  • Echinococcus Granulosus Infection Of Lung

  • Echinococcus Granulosus

  • Echinococcus Granulosus Infection Of Thyroid

  • Echinococcus Granulosus Infectious Disease

  • Echinococcus Granulosus Infectious Disease Of Liver

  • Echinococcus Granulosus Infectious Disease Of Thyroid

  • Liver Echinococcus Granulosus

  • Lung Echinococcus Granulosus

  • Thyroid Echinococcus Granulosus

  • Unilocular Echinococcosis

  • Unilocular Hydatid Disease

  • Hydatid Disease

  • Hydatidosis

  • Echinococcosis
Alveolar Echinococcosis

  • Echinococcus Multilocularis Infection

  • Echinococcosis

  • Alveolococcosis

  • Multilocular Hydatid

  • Small Fox Tapeworm
Birt-Hogg-Dube Syndrome

  • Hornstein-Knickenberg Syndrome

  • Fibrofolliculomas With Trichodiscomas And Acrochordons

  • BHD

  • Birt-Hogg-Dubé Syndrome

  • Multiple Fibrofolliculoma Familial

  • Bhd Syndrome

  • Birt Hogg Dube Syndrome

  • Hornstein-Birt-Hogg-Dubé Syndrome

  • Multiple Fibrofolliculomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12277 RRAGB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RRAGB MGD MGI:3038613
Bos taurus RRAGB VGNC VGNC:34159
Felis catus RRAGB VGNC VGNC:64768
Macaca mulatta RRAGB VGNC VGNC:77059
Rattus norvegicus RRAGB RGD RGD:619805
Canis familiaris RRAGB VGNC VGNC:54187
Others RRAGB NCBI