RRAGD - Ras related GTP binding D Gene

Also Known as RAGD; HOMG7; bA11D8.2.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58528

About RRAGD

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,364,616-89,412,273 (from NCBI)

This gene has 3 transcripts (splice variants), 186 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 16.9), heart (RPKM 13.1) and 20 other tissues.

Summary

RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]

RRAGD Products (1)

mRNA Protein Name
NM_021244.5 NP_067067.1 ras-related GTP-binding protein D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
32612235 GOA
enables GDP binding IMP
IMP: Inferred from mutant phenotype
22424946 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
22424946 GOA
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
22424946 GOA
enables GTPase binding IPI
IPI: Inferred from physical interaction
22424946 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
32612235 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11073942 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
11073942 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to L-leucine IMP
IMP: Inferred from mutant phenotype
22424946 GOA
involved in cellular response to leucine starvation IMP
IMP: Inferred from mutant phenotype
22424946 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
22424946 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11073942 GOA
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
34607910 GOA
located in lysosome IDA
IDA: Inferred from direct assay
20381137 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11073942 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
34607910 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAGD Protein Structure

Gtr1_RagA

Gtr1_RagA: Gtr1/RagA G protein conserved region (64 - 290)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

ras-related GTP-binding protein D

  • Rag D protein

RRAGD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RRAGD Q9NQL2 LARS1 Homo sapiens Q9P2J5
Pull Down
22424946
Intra
RRAGD Q9NQL2 LARS1 Homo sapiens Q9P2J5
Anti Tag CoIP
22424946
Intra
RRAGD Q9NQL2 LARS1 Homo sapiens Q9P2J5
IF
22424946
Intra
RRAGD Q9NQL2 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
22424946
Intra
RRAGD Q9NQL2 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
11073942
Intra
RRAGD Q9NQL2 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
22424946
Intra
RRAGD Q9NQL2 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
11073942
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Birt-Hogg-Dube Syndrome

  • Hornstein-Knickenberg Syndrome

  • Fibrofolliculomas With Trichodiscomas And Acrochordons

  • BHD

  • Birt-Hogg-Dubé Syndrome

  • Multiple Fibrofolliculoma Familial

  • Bhd Syndrome

  • Birt Hogg Dube Syndrome

  • Hornstein-Birt-Hogg-Dubé Syndrome

  • Multiple Fibrofolliculomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12279 RRAGD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21745 Rragd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28262 Rragd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RRAGD MGD MGI:1098604
Rattus norvegicus RRAGD RGD RGD:1310007
Macaca mulatta RRAGD VGNC VGNC:77061
Felis catus RRAGD VGNC VGNC:64770
Bos taurus RRAGD VGNC VGNC:34161
Canis familiaris RRAGD VGNC VGNC:49747
Others RRAGD NCBI