MARK1 - microtubule affinity regulating kinase 1 Gene

Also Known as MARK; Par1c; Par-1c

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4139

About MARK1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,528,136-220,664,461 (from NCBI)

This gene has 18 transcripts (splice variants), 230 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.9), testis (RPKM 3.5) and 21 other tissues.

Summary

Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MARK1 Products (5)

mRNA Protein Name
NM_001286124.2 NP_001273053.1 serine/threonine-protein kinase MARK1 isoform 1
NM_001286126.2 NP_001273055.1 serine/threonine-protein kinase MARK1 isoform 3
NM_001286128.2 NP_001273057.1 serine/threonine-protein kinase MARK1 isoform 4
NM_001286129.2 NP_001273058.1 serine/threonine-protein kinase MARK1 isoform 5
NM_018650.5 NP_061120.3 serine/threonine-protein kinase MARK1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
21145462 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
21145462 GOA
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
21145462 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23666762 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14976552 GOA
enables tau-protein kinase activity IMP
IMP: Inferred from mutant phenotype
23666762 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
14976552 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
31281935 GOA
acts upstream of negative regulation of gene expression IDA
IDA: Inferred from direct assay
31281935 GOA
acts upstream of positive regulation of gene expression IDA
IDA: Inferred from direct assay
31281935 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14976552 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23666762 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23666762 GOA
located in dendrite IDA
IDA: Inferred from direct assay
23666762 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21145462 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (60 - 311)

KA1

KA1: Kinase associated domain 1 (750 - 795)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase MARK1

  • MAP/microtubule affinity-regulating kinase 1

MARK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MARK1 Q9P0L2 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
Intra
MARK1 Q9P0L2 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
Intra
MARK1 Q9P0L2 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
MARK1 Q9P0L2 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
MARK1 Q9P0L2 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
MARK1 Q9P0L2 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
MARK1 Q9P0L2 TCL1B Homo sapiens O95988
Y2H Prey Pooling
32296183
Intra
MARK1 Q9P0L2 TCL1B Homo sapiens O95988
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MARK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811282 MARK1 Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Peutz-Jeghers Syndrome

  • PJS

  • Polyposis, Hamartomatous Intestinal

  • Polyps-And-Spots Syndrome

  • Lentiginosis, Perioral

  • Periorificial Lentiginosis Syndrome

  • Hamartomatous Intestinal Polyposis

  • Hamartomatous Polyp

  • Colonic Hamartomatous Polyp

  • Gastric Peutz-Jeghers Polyp

  • Peutz Jeghers Colon Polyp

  • Peutz Jeghers Polyp

  • Peutz-Jeghers Polyp Of Small Intestine

  • Peutz-Jeghers Small Bowel Hamartoma

  • Peutz Jeghers Polyposis

  • Intestinal Polyposis-Cutaneous Pigmentation Syndrome

  • Peutz-Jeghers Polyposis

  • Polyposis, Intestinal, Ii

  • Intestinal Hamartomatous Polyposis

  • Peutz-Jeghers Polyp

  • Peutz-Jeghers Polyp Of The Stomach

  • Peutz Jehgers Polyp

  • Peutz-Jeghers Polyps Of Small Bowel
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139604 PCC0208017 99.52% Unkown
HY-120877 MRT199665 99.85% Unkown
HY-120877A (R)-MRT199665 98.70% Unkown
HY-RS08149 MARK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21640 Mark1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28158 Mark1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MARK1 RGD RGD:619882
Canis familiaris MARK1 VGNC VGNC:49921
Felis catus MARK1 VGNC VGNC:68184
Macaca mulatta MARK1 VGNC VGNC:74658
Mus musculus MARK1 MGD MGI:2664902
Bos taurus MARK1 VGNC VGNC:103721
Others MARK1 NCBI