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Results for "

oxidation resistance

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P-glycoprotein (2) AAK1 (1) Akt (5) AMPK (2) Amylases (1) Amyloid-β (3) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (8) Arginase (3) ATP Citrate Lyase (2) Autophagy (4) Bacterial (11) Bcl-2 Family (2) Biochemical Assay Reagents (9) Calcium Channel (4) Caspase (4) CDK (1) Ceramidase (1) Claudin (2) COX (4) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (1) Deubiquitinase (1) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Metabolite (2) Endogenous Metabolite (9) Environmental Pollutants (5) ERK (3) Ferroptosis (2) FOXO (2) Fungal (6) Galectin (2) GSK-3 (1) HSP (2) HSV (1) IKK (1) Interleukin Related (2) Isotope-Labeled Compounds (3) JNK (2) Keap1-Nrf2 (2) LIM Kinase (LIMK) (1) Lipoxygenase (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Monoamine Oxidase (1) mTOR (1) NF-κB (4) NO Synthase (1) Opioid Receptor (1) Oxidative Phosphorylation (1) p38 MAPK (3) Parasite (2) PGE synthase (1) Phosphatase (2) PI3K (1) PKA (2) Polo-like Kinase (PLK) (1) PPAR (4) PROTACs (1) PTEN (1) Reactive Oxygen Species (ROS) (7) Reference Standards (9) Salt-inducible Kinase (SIK) (1) SnRK (1) SOD (2) STAT (1) Succinate Dehydrogenase (1) TGF-β Receptor (3) TNF Receptor (8) Toll-like Receptor (TLR) (1) Tyrosinase (1) Wee1 (1) α-synuclein (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (13) Endocrinology (1) Infection (11) Inflammation/Immunology (18) Metabolic Disease (24) Neurological Disease (13)

By Targets:

P-glycoprotein (2)

AAK1 (1)

Akt (5)

AMPK (2)

Amylases (1)

Amyloid-β (3)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (8)

Arginase (3)

ATP Citrate Lyase (2)

Autophagy (4)

Bacterial (11)

Bcl-2 Family (2)

Biochemical Assay Reagents (9)

Calcium Channel (4)

Caspase (4)

CDK (1)

Ceramidase (1)

Claudin (2)

COX (4)

Cyclin G-associated Kinase (GAK) (1)

Cytochrome P450 (1)

Deubiquitinase (1)

DNA/RNA Synthesis (1)

Drug Derivative (2)

Drug Metabolite (2)

Endogenous Metabolite (9)

Environmental Pollutants (5)

ERK (3)

Ferroptosis (2)

FOXO (2)

Fungal (6)

Galectin (2)

GSK-3 (1)

HSP (2)

HSV (1)

IKK (1)

Interleukin Related (2)

Isotope-Labeled Compounds (3)

JNK (2)

Keap1-Nrf2 (2)

LIM Kinase (LIMK) (1)

Lipoxygenase (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

Monoamine Oxidase (1)

mTOR (1)

NF-κB (4)

NO Synthase (1)

Opioid Receptor (1)

Oxidative Phosphorylation (1)

p38 MAPK (3)

Parasite (2)

PGE synthase (1)

Phosphatase (2)

PI3K (1)

PKA (2)

Polo-like Kinase (PLK) (1)

PPAR (4)

PROTACs (1)

PTEN (1)

Reactive Oxygen Species (ROS) (7)

Reference Standards (9)

Salt-inducible Kinase (SIK) (1)

SnRK (1)

SOD (2)

STAT (1)

Succinate Dehydrogenase (1)

TGF-β Receptor (3)

TNF Receptor (8)

Toll-like Receptor (TLR) (1)

Tyrosinase (1)

Wee1 (1)

α-synuclein (1)

By Research Areas:

Cancer (15)

Cardiovascular Disease (13)

Endocrinology (1)

Infection (11)

Inflammation/Immunology (18)

Metabolic Disease (24)

Neurological Disease (13)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: BCRP P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W145521

β-1,3-Glucan 1 Publications Verification β Glucan	Biochemical Assay Reagents IKK NO Synthase Bacterial	Infection Inflammation/Immunology Cancer
β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to *Vibrio harveyi* infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors .

HY-13817

IU1 20+ Cited Publications	Deubiquitinase Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Endocrinology Cancer
IU1 is a selective, reversible USP14 inhibitor with an IC₅₀ of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Endogenous Metabolite Autophagy mTOR SOD	Neurological Disease Metabolic Disease
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

HY-N2118

Bilobetin 2 Publications Verification	PPAR PKA Akt p38 MAPK ERK	Metabolic Disease
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-125848

Ginsenoside F2	Apoptosis AMPK PPAR p38 MAPK PI3K Akt GSK-3 Reactive Oxygen Species (ROS) SOD Caspase	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of AMPK and ACC, binds to PPARγ, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3β pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic AMPK signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota . Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma .

HY-N6804

Diammonium Glycyrrhizinate	NF-κB Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Diammonium glycyrrhizinate is a substance that can be extracted and purified from a traditional Chinese medicinal herb. Diammonium glycyrrhizinate has anti-inflammatory effect, resistance to biologic oxidation, membranous protection and a weak steroidal action. Diammonium glycyrrhizinate exerts protective effect by downregulating inflammation cytokines, suppressing the NF-κB pathway, and restoring superoxide dismutase. Diammonium glycyrrhizinate can be used as a hepatic protector and can therefore be studied in research for most liver diseases .

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	TNF Receptor Claudin HSP	Metabolic Disease Inflammation/Immunology
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-N3021

D-chiro-Inositol	Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin	Metabolic Disease
D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .

HY-N7079

Erythorbic acid D-Isoascorbic acid; D-Araboascorbic acid	Environmental Pollutants Biochemical Assay Reagents Bacterial	Cardiovascular Disease Metabolic Disease
Erythorbic acid is an orally active compound. Erythorbic acid improves the radiation resistance of *Listeria monocytogenes. Erythorbic acid can react with free radicals and reduce oxidative* damage. Erythorbic acid has weak antiscorbic activity. Erythorbic acid can prevent oxidative discoloration in meat products .

HY-Y0399

L-Norvaline Norvaline	Amyloid-β TNF Receptor Arginase	Neurological Disease Metabolic Disease
L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-W116336D

Zinc oxide, <100 nm particle size	Biochemical Assay Reagents Fungal Bacterial	Infection Cancer
Zinc oxide, <100 nm particle size is a nitrate reductase modulator and growth promoter with plant stress resistance activity and oral toxicity. Zinc oxide, <100 nm particle size acts as a nutrient source for maize plants. By enhancing nitrate reductase activity and reducing free proline levels, it significantly improves plant height, root length and dry matter weight of maize, and its growth-promoting effect is comparable to that of traditional zinc sulfate fertilizer. Zinc oxide, <100 nm particle size induces anemia-related and persistent tissue inflammatory damage, leading to obvious histopathological adverse reactions in the stomach, pancreas, eyes and prostate of rats. Zinc oxide, <100 nm particle size acts as a non-toxic antibacterial agent and selective cytotoxin against multiple bacteria, fungi and spores .

HY-N9497

Galactinol	Galectin Fungal	Infection
Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .

HY-17436

Clevidipine	Calcium Channel	Cardiovascular Disease Cancer
Clevidipine is a selective, short-acting L-type calcium channel antagonist with an IC₅₀ of 7.1 nM. Clevidipine can competitively bind to calcium channels and exert rapid vasoselective vasodilation by blocking the influx of extracellular calcium ions, thereby reducing peripheral vascular resistance and effectively controlling acute severe hypertension. Clevidipine can also protect the myocardium from reperfusion injury by promoting the release of nitric oxide (NO). Clevidipine can be used in the research of acute hypertension, perioperative blood pressure management, and myocardial ischemia-reperfusion injury .

HY-P10533

Cysteine peptide	Tyrosinase	Others
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .

HY-B2004

Thifluzamide	Environmental Pollutants Fungal Mitochondrial Metabolism	Infection
Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants .

HY-N2392

Kukoamine A 1 Publications Verification	Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE₂, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .

HY-N7079A

Sodium erythorbate D-Isoascorbic acid sodium; D-Araboascorbic acid sodium	Environmental Pollutants Biochemical Assay Reagents Bacterial	Cardiovascular Disease Metabolic Disease
Sodium erythorbate is an orally active sodium salt form of isoascorbic acid. Sodium erythorbate improves the radiation resistance of *Listeria monocytogenes. Sodium erythorbate can react with free radicals and reduce oxidative* damage. Sodium erythorbate has weak antiscorbic activity. Sodium erythorbate can prevent oxidative discoloration in meat products .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Endogenous Metabolite	Cardiovascular Disease
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent *nitric oxide* (NO) release promoter and endothelial nitric oxide synthase (eNOS)** activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-W012974

3-Aminoisobutyric acid β-Aminoisobutyric acid; BAIBA	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle .

HY-114243

DpC	NF-κB JNK Caspase Apoptosis	Neurological Disease Cancer
DpC is a selective, orally active iron chelator with anticancer activity. DpC acts on signaling pathway-related targets such as JNK, NF-κB, and its activity is competitively inhibited by another iron chelator Dp44mT (HY-18973). By chelating intracellular iron and copper ions in tumor cells to form redox-active complexes, DpC induces oxidative stress, activates the JNK, NF-κB pathways and downregulates IκBα, upregulates the expressions of neuroglobin and cytoglobin, activates caspase 3/9 to induce tumor cell apoptosis. It also overcomes P-glycoprotein-mediated multidrug resistance through a lysosome-targeting mechanism, and exhibits broad-spectrum synergistic effects when combined with various chemotherapeutic agents. DpC inhibits tumor metastasis and increases TNF-α levels in the tumor microenvironment to enhance endogenous immune responses. DpC is applicable to the research of various malignancies including neuroblastoma, pancreatic cancer, prostate cancer, lung cancer, and breast cancer .

HY-D1005A23

Poloxamer 401 (L121) PEG-PPG-PEG, 4400 (Average)	Environmental Pollutants Biochemical Assay Reagents P-glycoprotein	Inflammation/Immunology
Poloxamer 401 L121 is a block copolymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 4400. Poloxamer has the ability to inhibit P-gp. Poloxamer 401 inhibits multiagent resistance and adjuvant activity. Poloxamer 401 can be used as a cosmetic ingredient. Poloxamer 401 can be used in nanoparticle engineering (lymphatic targeting particles) research .

HY-12833

AMZ30 1 Publications Verification	Phosphatase Akt ERK	Others
AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC₅₀s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma .

HY-121235

Clonixin SCH-10304	COX Calcium Channel TGF-β Receptor	Neurological Disease Inflammation/Immunology
Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent (NSAID) that inhibits COX synthesis. Clonixin acts as a voltage-gated L-type calcium channel blocker, exerts vasodilatory effects by antagonizing Ca ²⁺ in vascular smooth muscle. Clonixin inhibits TGF-β, reduces lung coefficient, immune cell infiltration level, oxidative stress response, airway resistance, hydroxyproline content and collagen deposition. Clonixin can be used in research related to inflammation such as idiopathic pulmonary fibrosis and moderate to severe pain .

HY-148062

RSS0680	PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK	Others
RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].

HY-N7079R

Erythorbic acid (Standard) D-Isoascorbic acid (Standard); D-Araboascorbic acid (Standard)	Biochemical Assay Reagents Reference Standards Bacterial	Cardiovascular Disease Metabolic Disease
Erythorbic acid (Standard) (D-Isoascorbic acid (Standard)) is the analytical standard of Erythorbic acid (HY-N7079). This product is intended for research and analytical applications. Erythorbic acid is an orally active compound. Erythorbic acid improves the radiation resistance of *Listeria monocytogenes. Erythorbic acid can react with free radicals and reduce oxidative* damage. Erythorbic acid has weak antiscorbic activity. Erythorbic acid can prevent oxidative discoloration in meat products.

HY-153190

W1131 1 Publications Verification	Oxidative Phosphorylation STAT Ferroptosis	Cancer
W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway .

HY-N15841

C25 Ceramide (d18:1/25:0)	Ceramidase	Others
C25 Ceramide (d18:1/25:0) is an endogenous ultra-long-chain ceramide that antagonizes the detrimental effects of long-chain ceramides on insulin sensitivity. C25 Ceramide (d18:1/25:0) is specifically enriched in oxidative skeletal muscle fibers, where it serves dual roles in providing structural support to cell membranes and regulating cellular signaling. By participating in the regulation of lipid homeostasis within muscle fibers, C25 Ceramide (d18:1/25:0) helps maintain normal insulin signaling. C25 Ceramide (d18:1/25:0) is primarily utilized in research concerning metabolic diseases—particularly in mechanistic studies investigating the muscle fiber type-specific aspects of insulin resistance .

HY-N3287

Methyl 3-hydroxy-4,5-dimethoxybenzoate	Bacterial Fungal Reactive Oxygen Species (ROS)	Infection
Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant that can be isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H₂O₂ .

HY-135258

Galactinol dihydrate	Galectin Fungal	Others
Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .

HY-110067

VO-OHPic	PTEN Apoptosis Autophagy Ferroptosis Reactive Oxygen Species (ROS) Interleukin Related Akt Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology Cancer
VO-OHPic is a reversible, noncompetitive PTEN inhibitor with an human IC₅₀ value of 46 nM. VO-OHPic inhibits PTEN signaling, activates Akt-GSK3β and Nrf-2/HO-1 pathways, induces apoptosis resistance and elevates IL-10 levels. VO-OHPic inhibits autophagy, ferroptosis and oxidative stress. VO-OHPic can be used for the research of acute myocardial infarction, intervertebral disc degeneration, cardiomyopathy and cancer .

HY-N10405

(R)-5-Hydroxy-1,7-diphenyl-3-heptanone	Keap1-Nrf2	Metabolic Disease
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway .

HY-W088074A

Chromium(III)oxide, 99.9% trace metals basis	Environmental Pollutants Biochemical Assay Reagents	Others
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-Y0399S

L-Norvaline-d5	Isotope-Labeled Compounds Amyloid-β TNF Receptor Arginase	Neurological Disease Metabolic Disease
L-Norvaline-d₅ is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-Y0399R

L-Norvaline (Standard)	Amyloid-β Reference Standards TNF Receptor Arginase	Neurological Disease Metabolic Disease
L-Norvaline (Standard) is the analytical standard of L-Norvaline (HY-Y0399). This product is intended for research and analytical applications. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-P2819

Phosphofructokinase 1 PFK1	Phosphatase	Metabolic Disease
Phosphofructokinase 1 (PFK1) is a major regulatory enzyme targeting glycolytic pathway. Phosphofructokinase 1 catalyzes the phosphorylation of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP) to regulate glycolytic flux. Phosphofructokinase 1 is promising for research of cancer metabolic reprogramming (e.g., hypoxia adaptation, oxidative stress resistance) and metabolic syndromes .

HY-N3021R

D-chiro-Inositol (Standard)	Reference Standards Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin	Metabolic Disease
D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .

HY-N9680

Coenzyme Q8 Ubiquinone 8	Endogenous Metabolite Bacterial	Infection Inflammation/Immunology
Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and reduces oxidative stress. Coenzyme Q8 maintains bacterial respiratory function and enhances host resistance to bacterial infection. Coenzyme Q8 stimulates macrophage phagocytosis and increases antibody-producing cells. Coenzyme Q8 can be used in infectious disease research .

HY-N2468R

Xylobiose (Standard) 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)	Reference Standards TNF Receptor Claudin HSP	Metabolic Disease Inflammation/Immunology
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-161521

PLK1-IN-10	Polo-like Kinase (PLK)	Cancer
PLK1-IN-10 (Compound 4Bb) is an orally active PLK1 PBD (polo-box domain) inhibitor. PLK1-IN-10 blocks the interaction of PLK1 with the cell division regulator protein 1 (PRC1) and decreases the protein expression of the CDK1-Cyclin B1 complex. PLK1-IN-10 reacts with glutathione (GSH) to increase cellular oxidative stress, ultimately leading to cell death .

HY-W207699

MAO-B-IN-46	Monoamine Oxidase Amylases	Neurological Disease Metabolic Disease Inflammation/Immunology
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC₅₀: 26.8 nM), with weak activity against hMAO-A (IC₅₀: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC₅₀: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC₅₀ values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance .

HY-N9511

Jacobine N-oxide	Others	Others
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .

HY-117161

ZINC05626394	Cytochrome P450	Cancer
ZINC05626394 is a cytochrome b5 reductase 3 inhibitor with activity by increasing nitric oxide bioavailability. ZINC05626394 may have potential applications in anti-cancer suppression, especially in combination with antibody drug conjugates (ADCs) and immune checkpoint inhibitors. The efficacy of ZINC05626394 may be limited by different mechanisms, including antigen-related resistance and failure of endocytosis .

HY-179217

GSTP1/M2-IN-1	JNK Apoptosis	Cancer
GSTP1/M2-IN-1 is a GSTP1/GSTM2 inhibitor(IC₅₀ = 1.56 μM/0.09 μM). GSTP1/M2-IN-1 can activate the JNK pathway and induce cell apoptosis. GSTP1/M2-IN-1 can be used for the study of breast cancer and pancreatic cancer .

HY-N2118R

Bilobetin (Standard)	Reference Standards PPAR PKA Akt p38 MAPK ERK	Metabolic Disease
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-165098

3-Aminoisobutyric acid sodium salt β-Aminoisobutyric acid sodium salt; BAIBA sodium salt	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
3-Aminoisobutyric acid (β-Aminoisobutyric acid) sodium salt has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid sodium salt increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid sodium salt attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid sodium salt is a catabolic metabolite of thymine and valine in skeletal muscle .

HY-161823

Anti-MRSA agent 13	Bacterial	Infection
Anti-MRSA agent 13 (Compound 9b) is an agent against methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a minimum inhibitory concentration (MIC) of 0.5–2 μg/mL against clinically isolated MRSA strains. Anti-MRSA agent 13 possesses favorable biosafety, plasma tolerance stability, and a low tendency to develop resistance. Anti-MRSA agent 13 disrupts cell walls and membranes, reduces metabolic activity, causes oxidative damage, affects DNA function, and ultimately leads to MRSA death through multi-target synergies .

HY-W012974R

3-Aminoisobutyric acid (Standard) β-Aminoisobutyric acid (Standard); BAIBA (Standard)	Reference Standards Endogenous Metabolite AMPK PPAR	Cardiovascular Disease Metabolic Disease
3-Aminoisobutyric acid (Standard) is the analytical standard of 3-Aminoisobutyric acid. This product is used for research and analytical applications. 3-Aminoisobutyric acid (β-Aminoisobutyric acid) exhibits anti-inflammatory and antioxidant effects. It increases the expression of brown fat cell-specific genes in white adipose tissue and enhances fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid alleviates insulin resistance and inflammation induced by palmitic acid or a high-fat diet in mice via the AMPK–PPARδ-dependent pathway. 3-Aminoisobutyric acid is a catabolite of thymine and valine in skeletal muscle .

HY-168953

Lysosomal P-gp targeted agent 1	P-glycoprotein Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS) Caspase	Cancer
Lysosomal P-gp targeted agent 1 (Compound 14) is an anti-tumor agent targeting lysosomal P-glycoprotein (Pgp). Lysosomal P-gp targeted agent 1 is selectively transported into lysosomes by overexpressed Pgp, release nitric oxide (NO) to generate reactive oxygen species (ROS), resulting in lysosomal membrane permeabilization (LMP) and inducing apoptosis. Lysosomal P-gp targeted agent 1 can overcome P-glycoprotein-mediated drug resistance and lead to cell cycle arrest, but relatively low toxicity to normal cells. Lysosomal P-gp targeted agent 1 has antitumor activity, significantly inhibits tumor volume .

HY-121235R

Clonixin (Standard) SCH-10304 (Standard)	Reference Standards COX Calcium Channel TGF-β Receptor	Neurological Disease Inflammation/Immunology
Clonixin (SCH-10304) (Standard) is the analytical standard of Clonixin. This product is intended for research and analytical applications. Clonixin is an orally active non-steroidal anti-inflammatory agent (NSAID) that inhibits COX synthesis. Clonixin acts as a voltage-gated L-type calcium channel blocker, exerts vasodilatory effects by antagonizing Ca ²⁺ in vascular smooth muscle. Clonixin inhibits TGF-β, reduces lung coefficient, immune cell infiltration level, oxidative stress response, airway resistance, hydroxyproline content and collagen deposition. Clonixin can be used in research related to inflammation such as idiopathic pulmonary fibrosis and moderate to severe pain .

HY-133676S

Mono(2-ethyl-5-oxohexyl) phthalate-d4	Isotope-Labeled Compounds Drug Metabolite	Others
Mono(2-ethyl-5-oxohexyl) phthalate-d₄ is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

Cat. No.	Product Name

HY-L228

Lipid Metabolite Compound Library

145 compounds

Lipids are important energy storage substances in the human body. They are involved in the regulation of cell structure and function, as well as signaling pathways and gene expression. Abnormal lipid levels in tissues or their dysregulation can lead to various diseases. These include obesity, type 2 diabetes, non-alcoholic fatty liver disease, neurodegenerative diseases, infections, and cancer. Therefore, maintaining normal levels of lipid metabolism is critical to overall health.

One of the key features of cancer is aberrant lipid metabolism. This includes alterations in lipid uptake, lipid desaturation, neolipogenesis, lipid droplets, and fatty acid oxidation in cancer cells. These changes all contribute to cellular survival in an ever-changing microenvironment. They do this by modulating feed-forward oncogenic signals and key oncogenic functions. Additionally, they affect oxidative stress, other types of stress, immune responses, and intercellular communication. Alterations in lipid metabolism have a strong impact on the properties of cancer stem cells. This includes aspects such as self-renewal, differentiation, invasion, metastasis, drug sensitivity, and resistance. Furthermore, these alterations also modulate T cell responses.

MCE can offer 145 metabolites of lipid metabolism pathways, which can be used for drug screening in cancer, immune-based diseases, metabolic diseases, and other diseases.

Cat. No.	Product Name	Type

HY-113053F

Prostaglandin A1-biotin PGA1-biotin	Fluorescent Dyes
Prostaglandin A1-biotin (PGA1-biotin) is a biotin-labeled Prostaglandin A1 (HY-113053). Prostaglandin A1-biotin can be found in the culture filtrate of rhizobia, and the culture filtrate containing this compound exhibits significant antiviral activity .

Cat. No.	Product Name	Type

HY-W145521

β-1,3-Glucan

1 Publications Verification

β Glucan

Biochemical Assay Reagents

β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors .

HY-W116336D

Zinc oxide, <100 nm particle size

Biochemical Assay Reagents

Zinc oxide, <100 nm particle size is a nitrate reductase modulator and growth promoter with plant stress resistance activity and oral toxicity. Zinc oxide, <100 nm particle size acts as a nutrient source for maize plants. By enhancing nitrate reductase activity and reducing free proline levels, it significantly improves plant height, root length and dry matter weight of maize, and its growth-promoting effect is comparable to that of traditional zinc sulfate fertilizer. Zinc oxide, <100 nm particle size induces anemia-related and persistent tissue inflammatory damage, leading to obvious histopathological adverse reactions in the stomach, pancreas, eyes and prostate of rats. Zinc oxide, <100 nm particle size acts as a non-toxic antibacterial agent and selective cytotoxin against multiple bacteria, fungi and spores .

HY-N9497

Galactinol

Biochemical Assay Reagents

Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .

HY-D1005A23

Poloxamer 401 (L121) PEG-PPG-PEG, 4400 (Average)	Biochemical Assay Reagents
Poloxamer 401 L121 is a block copolymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 4400. Poloxamer has the ability to inhibit P-gp. Poloxamer 401 inhibits multiagent resistance and adjuvant activity. Poloxamer 401 can be used as a cosmetic ingredient. Poloxamer 401 can be used in nanoparticle engineering (lymphatic targeting particles) research .

HY-W088074A

Chromium(III)oxide, 99.9% trace metals basis	Biochemical Assay Reagents
Chromium(III)oxide, 99.9% trace metals basis is an important refractory material with its high melting point temperature and oxidation resistance .

HY-B0167E

Salicylic acid Sterile Solution (1 mg/ml)

Biochemical Assay Reagents

Salicylic acid Sterile Solution (1 mg/mL) is a sterile solution suitable for plant culture. Salicylic acid (HY-B0167) is a weak acid that, once inside the plant, can activate growth regulators such as nitric oxide, thereby influencing plant growth and development. Salicylic acid can also regulate plant cell metabolism and membrane permeability, improving the plant's resistance to adverse conditions.

Cat. No.	Product Name	Target	Research Area

HY-P10533

Cysteine peptide	Tyrosinase	Others
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .

HY-P11580

Pap12-6-10	Toll-like Receptor (TLR) Bacterial	Infection
Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the TLR4/MD-2 complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	Endogenous Metabolite Autophagy mTOR SOD
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

HY-N2118

Bilobetin 2 Publications Verification	Flavonoids Ginkgoaceae Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Biflavones Ginkgo biloba Disease Research Fields Source Classification	PPAR PKA Akt p38 MAPK ERK
Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-125848

Ginsenoside F2	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification Cancer	Apoptosis AMPK PPAR p38 MAPK PI3K Akt GSK-3 Reactive Oxygen Species (ROS) SOD Caspase
Ginsenoside F2 is an orally active bioactive compound that participates in the regulation of metabolism and inflammation. Ginsenoside F2 promotes the phosphorylation of AMPK and ACC, binds to PPARγ, inhibits the phosphorylation of MAPK, activates the PI3K/AKT/GSK-3β pathway, reduces GLRX expression, and regulates lipid metabolism. Ginsenoside F2 reduces ROS production and MDA levels, restores SOD activity in cells, and alleviates oxidative stress. Ginsenoside F2 induces cell apoptosis (Apoptosis) and increases the number of cleaved caspase-3-positive cells. Ginsenoside F2 reduces body weight gain, adipose tissue weight and serum lipid levels in obese mice, and activates the hepatic AMPK signaling pathway and the expression of antioxidant enzymes. Ginsenoside F2 alleviates atopic dermatitis in mice by inhibiting inflammation and reshaping the gut microbiota . Ginsenoside F2 is applicable to research related to insulin resistance, obesity, atopic dermatitis, liver cancer, glioblastoma and glioma .

HY-N6804

Diammonium Glycyrrhizinate	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	NF-κB Reactive Oxygen Species (ROS)
Diammonium glycyrrhizinate is a substance that can be extracted and purified from a traditional Chinese medicinal herb. Diammonium glycyrrhizinate has anti-inflammatory effect, resistance to biologic oxidation, membranous protection and a weak steroidal action. Diammonium glycyrrhizinate exerts protective effect by downregulating inflammation cytokines, suppressing the NF-κB pathway, and restoring superoxide dismutase. Diammonium glycyrrhizinate can be used as a hepatic protector and can therefore be studied in research for most liver diseases .

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	Zea mays L. Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharides Source Classification	TNF Receptor Claudin HSP
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-N3021

D-chiro-Inositol	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin
D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .

HY-N7079

Erythorbic acid D-Isoascorbic acid; D-Araboascorbic acid	Natural Products Microorganisms Other Diseases Disease Research Fields Source Classification	Environmental Pollutants Biochemical Assay Reagents Bacterial
Erythorbic acid is an orally active compound. Erythorbic acid improves the radiation resistance of *Listeria monocytogenes. Erythorbic acid can react with free radicals and reduce oxidative* damage. Erythorbic acid has weak antiscorbic activity. Erythorbic acid can prevent oxidative discoloration in meat products .

HY-Y0399

L-Norvaline Norvaline	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Amyloid-β TNF Receptor Arginase
L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-N9497

Galactinol	Source Classification	Galectin Fungal
Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot .

HY-N2392

Kukoamine A 1 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Phenols Polyphenols Plants Disease Research Fields Source Classification	Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE₂, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .

HY-N7079A

Sodium erythorbate D-Isoascorbic acid sodium; D-Araboascorbic acid sodium	Natural Products Microorganisms Disease Research Fields Source Classification Cancer	Environmental Pollutants Biochemical Assay Reagents Bacterial
Sodium erythorbate is an orally active sodium salt form of isoascorbic acid. Sodium erythorbate improves the radiation resistance of *Listeria monocytogenes. Sodium erythorbate can react with free radicals and reduce oxidative* damage. Sodium erythorbate has weak antiscorbic activity. Sodium erythorbate can prevent oxidative discoloration in meat products .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Cardiovascular Disease Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent *nitric oxide* (NO) release promoter and endothelial nitric oxide synthase (eNOS)** activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-W012974

3-Aminoisobutyric acid β-Aminoisobutyric acid; BAIBA	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Aminoisobutyric acid (β-Aminoisobutyric acid) has anti-inflammatory and antioxidant effects. 3-Aminoisobutyric acid increases the expression of brown adipocyte-specific genes in white adipose tissue and fatty acid β-oxidation in hepatocytes. 3-Aminoisobutyric acid attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. 3-Aminoisobutyric acid is a catabolic metabolite of thymine and valine in skeletal muscle .

HY-N7079R

Erythorbic acid (Standard) D-Isoascorbic acid (Standard); D-Araboascorbic acid (Standard)	Natural Products Microorganisms Source Classification	Biochemical Assay Reagents Reference Standards Bacterial
Erythorbic acid (Standard) (D-Isoascorbic acid (Standard)) is the analytical standard of Erythorbic acid (HY-N7079). This product is intended for research and analytical applications. Erythorbic acid is an orally active compound. Erythorbic acid improves the radiation resistance of *Listeria monocytogenes. Erythorbic acid can react with free radicals and reduce oxidative* damage. Erythorbic acid has weak antiscorbic activity. Erythorbic acid can prevent oxidative discoloration in meat products.

HY-N15841

C25 Ceramide (d18:1/25:0)	Structural Classification Lipid	Ceramidase
C25 Ceramide (d18:1/25:0) is an endogenous ultra-long-chain ceramide that antagonizes the detrimental effects of long-chain ceramides on insulin sensitivity. C25 Ceramide (d18:1/25:0) is specifically enriched in oxidative skeletal muscle fibers, where it serves dual roles in providing structural support to cell membranes and regulating cellular signaling. By participating in the regulation of lipid homeostasis within muscle fibers, C25 Ceramide (d18:1/25:0) helps maintain normal insulin signaling. C25 Ceramide (d18:1/25:0) is primarily utilized in research concerning metabolic diseases—particularly in mechanistic studies investigating the muscle fiber type-specific aspects of insulin resistance .

HY-N3287

Methyl 3-hydroxy-4,5-dimethoxybenzoate	Infection Monophenols Classification of Application Fields Phenols Euphorbiaceae Plants Macaranga sinensis (Baill.) Muell. Arg. Disease Research Fields Source Classification	Bacterial Fungal Reactive Oxygen Species (ROS)
Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant that can be isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H₂O₂ .

HY-N10405

(R)-5-Hydroxy-1,7-diphenyl-3-heptanone	Natural Products Classification of Application Fields Metabolic Disease Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae	Keap1-Nrf2
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway .

HY-Y0399R

L-Norvaline (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Amyloid-β Reference Standards TNF Receptor Arginase
L-Norvaline (Standard) is the analytical standard of L-Norvaline (HY-Y0399). This product is intended for research and analytical applications. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-N3021R

D-chiro-Inositol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin
D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome .

HY-N9680

Coenzyme Q8 Ubiquinone 8	Quinones Structural Classification Leguminosae Pisum sativum Linn Benzene Quinones Plants Source Classification	Endogenous Metabolite Bacterial
Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and reduces oxidative stress. Coenzyme Q8 maintains bacterial respiratory function and enhances host resistance to bacterial infection. Coenzyme Q8 stimulates macrophage phagocytosis and increases antibody-producing cells. Coenzyme Q8 can be used in infectious disease research .

HY-N2468R

Xylobiose (Standard) 1,4-β-D-Xylobiose (Standard); 1,4-D-Xylobiose (Standard)	Structural Classification Zea mays L. Polysaccharides Gramineae Plants Saccharides Source Classification	Reference Standards TNF Receptor Claudin HSP
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome .

HY-N9511

Jacobine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Other Diseases Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Source Classification	Others
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .

HY-N2118R

Bilobetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Phenols Polyphenols Plants Biflavones Ginkgo biloba Source Classification	Reference Standards PPAR PKA Akt p38 MAPK ERK
Bilobetin (Standard) is the analytical standard of Bilobetin. This product is intended for research and analytical applications. Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity .

HY-N7079AR

Sodium erythorbate (Standard) D-Isoascorbic acid sodium (Standard); D-Araboascorbic acid sodium (Standard)	Natural Products Microorganisms Source Classification	Biochemical Assay Reagents Bacterial Reference Standards
Sodium erythorbate (Standard) (D-Isoascorbic acid (sodium) (Standard)) is the analytical standard of Sodium erythorbate (HY-N7079A). This product is intended for research and analytical applications. Sodium erythorbate is an orally active sodium salt form of isoascorbic acid. Sodium erythorbate improves the radiation resistance of Listeria monocytogenes. Sodium erythorbate can react with free radicals and reduce oxidative damage. Sodium erythorbate has weak antiscorbic activity. Sodium erythorbate can prevent oxidative discoloration in meat products .

HY-122301

Sarcinaxanthin	Structural Classification Natural Products Microorganisms Source Classification	Drug Derivative
Sarcinaxanthin is a carotenoid present in various bacteria with antioxidant activity. Sarcinaxanthin scavenges singlet oxygen, thereby inhibiting oxidative degradation in the β-carotene/linoleic acid system. Sarcinaxanthin acts as a photoprotective agent against UVB radiation that induces erythema. Sarcinaxanthin can be applied in studies related to antioxidation and radiation resistance .

HY-N17816

Tambulin	Structural Classification Flavonoids Flavones Rutaceae Plants Zanthoxylum armatum DC. Source Classification	Apoptosis Reactive Oxygen Species (ROS) α-synuclein Succinate Dehydrogenase Bcl-2 Family Caspase
Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes .

HY-N19083

Tecomella undulata extract	Structural Classification Extract	Bacterial
Tecomella undulata Extract, also known as Rohida extract, is a valuable botanical extract derived from the bark and leaves of the Tecomella undulata plant native to the Indian Thar Desert and is rich in bioactive compounds such as flavonoids, quinones, triterpenoids, and other phytochemicals that contribute to its diverse therapeutic properties. This extract is widely recognized for its hepatoprotective effects demonstrated through its ability to protect against liver damage induced by toxins such as paracetamol and carbon tetrachloride by normalizing elevated liver enzyme levels reducing oxidative stress and improving liver function. Additionally, it exhibits significant anti-inflammatory activity comparable to standard drugs like indomethacin and has been used to treat conditions like ascites and hepatosplenomegaly while also showing immunomodulatory effects by enhancing both humoral and cell-mediated immune responses and possessing antimicrobial properties that make it effective against various pathogens. Recent research suggests that Tecomella undulata may have potential in managing nonalcoholic steatohepatitis (NASH) by reducing body weight insulin resistance and improving liver function markers making it a versatile natural remedy with significant applications in hepatoprotection anti-inflammation and immune support.

Cat. No.	Product Name	Chemical Structure

HY-Y0399S

L-Norvaline-d5
L-Norvaline-d₅ is the deuterium labeled L-Norvaline. L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-133676S

Mono(2-ethyl-5-oxohexyl) phthalate-d4

Mono(2-ethyl-5-oxohexyl) phthalate-d₄ is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .

HY-121235S1

Clonixin-13C,d3

Clonixin- ¹³C,d₃ (SCH-10304- ¹³C,d₃) is the deuterium and ¹³C-labeled Clonixin (HY-121235). Clonixin is an orally active non-steroidal anti-inflammatory agent (NSAID) that inhibits COX synthesis. Clonixin acts as a voltage-gated L-type calcium channel blocker, exerts vasodilatory effects by antagonizing Ca ²⁺ in vascular smooth muscle. Clonixin inhibits TGF-β, reduces lung coefficient, immune cell infiltration level, oxidative stress response, airway resistance, hydroxyproline content and collagen deposition. Clonixin can be used in research related to inflammation such as idiopathic pulmonary fibrosis and moderate to severe pain.

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P811158

	RAB3GAP2 Antibody oxidation resistance protein 1	WB, IHC-P	Human, Mouse, Rat
	RAB3GAP2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB3GAP2.

HY-P811156

	OXR1 Antibody Nbla00307, OXR1, oxidation resistance protein 1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	OXR1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to OXR1.

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