RAB3GAP2 Antibody
(Synonyms: Oxidation resistance protein 1)RAB3GAP2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB3GAP2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
RAB3GAP2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB3GAP2.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 156 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 155 kDa
Synthetic peptide corresponding to the center region of human RAB3GAP2.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RAB3GAP2 is a Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. The complex has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and has guanine nucleotide exchange factor (GEF) activity towards RAB18. The Rab3GAP complex acts as a GEF for RAB18 by promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)[1][2][3][4].
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Subcellular Localization
Cytoplasm; Endoplasmic reticulum
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Expression
Tissue_Specificity: Ubiquitous. -
Isoforms & Post-Translational Modification
RAB3GAP2 has 2 isoforms, Q9H2M9-1: amino acid length is 1393, molecular weight is 155985 Da (predicted); Q9H2M9-2: amino acid length is 206, molecular weight is 23361 Da (predicted).
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Subunit
The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP1 and RAB3GAP2 (By similarity).
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SwissProt ID
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Synonyms
Oxidation resistance protein 1
Documentation
References
[1]. Nagano F, et al. Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein. J Biol Chem. 1998 Sep 18;273(38):24781-5. [Content Brief]
[2]. Fairlie GMJ, et al. Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity. Nat Commun. 2025 Jan 8;16(1):479. [Content Brief]
[3]. Gerondopoulos A, et al. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014 Jun 9;205(5):707-20. [Content Brief]
[4]. Handley MT, et al. Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation. Open Biol. 2015 Jun;5(6):150047. [Content Brief]
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