OXR1 Antibody
(Synonyms: Nbla00307, OXR1, Oxidation resistance protein 1)OXR1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to OXR1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
OXR1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to OXR1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 97 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 97 kDa
Synthetic peptide corresponding to the center region of human OXR1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
OXR1 inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex. Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage. Protects neuronal cells from oxidative stress (By similarity)[1][2][3].
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Subcellular Localization
Mitochondrion; Nucleus, nucleolus; Golgi apparatus, cis-Golgi network membrane; Golgi apparatus, trans-Golgi network membrane
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Expression
Induction: By heat shock and oxidative stress. -
Isoforms & Post-Translational Modification
OXR1 has 8 isoforms, Q8N573-1: amino acid length is 874, molecular weight is 97970 Da (predicted); Q8N573-2: amino acid length is 839, molecular weight is 93734 Da (predicted); Q8N573-3: amino acid length is 503, molecular weight is 55698 Da (predicted); Q8N573-4: amino acid length is 243, molecular weight is 27691 Da (predicted); Q8N573-5: amino acid length is 846, molecular weight is 94692 Da (predicted); Q8N573-6: amino acid length is 294, molecular weight is 33774 Da (predicted); Q8N573-7: amino acid length is 216, molecular weight is 24468 Da (predicted); Q8N573-8: amino acid length is 873, molecular weight is 97916 Da (predicted).在过氧化氢诱导的氧化应激后会发生氧化修饰OXR1 存在 8 个异构体，Q8N573-1：氨基酸个数为 874 个，分子量为 97970 Da (预测)；Q8N573-2：氨基酸个数为 839 个，分子量为 93734 Da (预测)；Q8N573-3：氨基酸个数为 503 个，分子量为 55698 Da (预测)；Q8N573-4：氨基酸个数为 243 个，分子量为 27691 Da (预测)；Q8N573-5：氨基酸个数为 846 个，分子量为 94692 Da (预测)；Q8N573-6：氨基酸个数为 294 个，分子量为 33774 Da (预测)；Q8N573-7：氨基酸个数为 216 个，分子量为 24468 Da (预测)；Q8N573-8：氨基酸个数为 873 个，分子量为 97916 Da (预测)。Undergoes oxidation following oxidative stress induced by hydrogen peroxide
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Subunit
Interacts (via TLDc domain) with vacuolar-type ATPase (V-ATPase) subunit ATP6V1B1.
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SwissProt ID
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Synonyms
Nbla00307, OXR1, Oxidation resistance protein 1
Documentation
References
[1]. Oot RA, et al. Human V-ATPase function is positively and negatively regulated by TLDc proteins. Structure. 2024 Jul 11;32(7):989-1000.e6. [Content Brief]
[2]. Volkert MR, et al. Functional genomics reveals a family of eukaryotic oxidation protection genes. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14530-5. [Content Brief]
[3]. Elliott NA, et al. Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. Mol Cell Biol. 2004 Apr;24(8):3180-7. [Content Brief]
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